초록

In an approach to genetic therapy for treating tumors, a genetic construction encoding the p35 and p40 subunits of the cytokine IL-12 is delivered into cells of individuals in need of therapy so as to express IL-12 in cells and to cause regression of established tumors.

대표청구항 ▼

[ We claim:] [1.] A method of treating tumors in a mammal, comprising:a) providing a vector comprising an expressible genetic construct, wherein said genetic construct comprises a first DNA sequence encoding a p35 subunit of IL-12 and a second DNA sequence encoding a p40 subunit of IL-12, wherein sa

[ We claim:] [1.] A method of treating tumors in a mammal, comprising:a) providing a vector comprising an expressible genetic construct, wherein said genetic construct comprises a first DNA sequence encoding a p35 subunit of IL-12 and a second DNA sequence encoding a p40 subunit of IL-12, wherein said first and second DNA sequences are operably linked to a promoter; andb) introducing the vector into a target cell of the mammal in vivo, wherein said vector is delivered into tissue surrounding or adjacent to a tumor, and whereby said first and second DNA sequences are expressed by the cell to provide said IL-12 subunits at a level sufficient to inhibit tumor growth.