[특허]Embryonal cardiac muscle cells, their preparation and their use

[미국특허] Embryonal cardiac muscle cells, their preparation and their use 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	C12N-005/06 C12N-005/10 C12N-005/16 C12Q-001/02
출원번호	US-0849706 (1997-08-22)
우선권정보	DE-4441327 (1994-11-22)
국제출원번호	PCT/DE95/01699 (1995-11-21)
§371/§102 date	19970822 (19970822)
국제공개번호	WO-9616163 (1996-05-30)
발명자 / 주소	Franz Wolfgang-Michael,DEX Wobus Anna M.,DEX
출원인 / 주소	Institut fur Pflanzengenetik und Kulturpflanzenforschung, DEX
대리인 / 주소	Kasper
인용정보	피인용 횟수 : 42 인용 특허 : 0

초록 ▼

The invention concerns embryonal (cardiomyocytary and cardiomyoblastary) cardiac muscle cells, their preparation and their use, in particular for cell-mediated gene transplant. The areas of application of the invention are medicine and genetic engineering. The embryonal cardiac muscle cells according to the invention contain two gene constructs comprising: a) a regulatory, 1.2-kb long DNA sequence of the ventricle-specific myosin light-chain-2 (MLC-2v) promoter, the selectable marker gene .beta.-galactosidase in fusion with the reporter gene neomycin; and b) a regulatory DNA sequence of the herpes simplex virus thymidine kinase promoter and the selectable marker gene hygromycin, and optionally immortalizing genes and/or optionally genes inactivated by homologous recombination and/or optionally one or a plurality of therapeutic genes. The cells can advantageously be used for cell-mediated gene transplant, in particular for constructing healthy tissue and assisting contractile functions, for investigating substances, in particular for pharmacological investigations and for the transfer of therapeutic genes into the myocardium.

대표청구항

[ We claim:] [1.] An embryonal cardiac muscle cell, essentially consisting of two gene constructs of two different regulatory DNA sequences and two different selectable marker genes.

이 특허를 인용한 특허 (42) 인용/피인용 타임라인 분석

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Verfaillie, Catherine M.; Reyes, Morayma; Furcht, Leo T., Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure.
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[미국특허] Embryonal cardiac muscle cells, their preparation and their use 원문보기