초록 ▼

Disclosed are budesonide pellets with a controlled release pattern containing, from the inside to the outside: a) neutral pellets; b) an active principle layer of micronized budesonide and one or more water-soluble auxiliaries; c) a first lacquer coating consisting of 80 to 97% of at least one lacqu

Disclosed are budesonide pellets with a controlled release pattern containing, from the inside to the outside: a) neutral pellets; b) an active principle layer of micronized budesonide and one or more water-soluble auxiliaries; c) a first lacquer coating consisting of 80 to 97% of at least one lacquer insoluble in gastric fluids but soluble in intestinal fluids and 3 to 20% of at least one lacquer insoluble in both gastric and intestinal fluids; and d) a second lacquer coating consisting of at least one lacquer insoluble in gastric and intestinal fluids. The invention also relates to a process for producing budesonide pellets with a controlled release pattern.

대표청구항 ▼

[ We claim:] [1.] Budesonide pellets with a controlled release profile, where the release of active substance is 0% after 15 minutes and at least 90% after 120 minutes, which pellets comprise, from the inside to the outside:a) sugar spheres;b) an active substance layer comprising micronized budesoni

[ We claim:] [1.] Budesonide pellets with a controlled release profile, where the release of active substance is 0% after 15 minutes and at least 90% after 120 minutes, which pellets comprise, from the inside to the outside:a) sugar spheres;b) an active substance layer comprising micronized budesonide and one or more water-soluble auxiliaries;c) a first lacquer layer comprising 80 to 97% of at least one lacquer which is insoluble in gastric fluid and soluble in intestinal fluid and 3 to 20% of at least one lacquer which is insoluble in gastric and intestinal fluids; and,d) a second lacquer consisting of 100% of at least one lacquer which is insoluble in gastric and intestinal fluids.