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Collagenase-1 and stromelysin-1 inhibitors, pharmaceutical compositions comprising same and methods of their use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/495
  • C07D-024/136
  • C07D-024/104
  • C07D-023/700
출원번호 US-0665603 (1996-06-18)
발명자 / 주소
  • Campbell David
  • Look Gary C.
  • Szardenings Anna Katrin
  • Patel Dinesh V.
출원인 / 주소
  • Affymax Technologies N.V., GBX
대리인 / 주소
    Swiss
인용정보 피인용 횟수 : 43  인용 특허 : 11

초록

Novel inhibitors of metalloproteases, in particular collagenase-1 and stromelysin-1, are disclosed. Such compounds are useful in pharmaceutical compositions and methods for treating or controlling disease states or conditions which involve tissue breakdown, such as rheumatoid arthritis. [ STR 1 ]

대표청구항

[ What is claimed is:] [1.] A compound of formula: [ STR 13 ] wherein R.sup.1 is --CH.sub.2 R.sup.8 ; andR.sup.8 is selected from the group consisting of an alkyl group of from 1 to 12 carbon atoms; an aryl group of from 6 to 10 carbon atoms; and arylalkyl;R.sup.3, R.sup.4, R.sup.5, R.sup.6, and R.s

이 특허에 인용된 특허 (11)

  1. Campion Colin (Oxon GB2) Davidson Alan H. (Oxon GB2) Dickens Jonathan P. (Buckinghamshire GB2) Crimmin Michael J. (Ascot GB2), Hydroxamic acid based collagenase inhibitors.
  2. Dickens Jonathan P. (High Wycombe GB2) Donald David K. (High Wycombe GB2) Kneen Geoffrey (West Wycombe GB2) McKay William R. (High Wycombe GB2), Hydroxamic acid based collagenase inhibitors.
  3. Davidson Alan H. (Witney GB2) Dickens Jonathan P. (High Wycombe GB2) Crimmin Michael J. (Ascot GB2), Hydroxamic acid collagenase inhibotors.
  4. Jacobsen E. Jon, Hydroxamic acid derivatives useful for the treatment of diseases related to connective tissue degradation.
  5. Campion Colin (Oxon GB2) Davidson Alan H. (Oxon GB2) Dickens Jonathan P. (Buckinghamshire GB2) Crimmin Michael J. (Ascot GB2), Hydroxamino acid based collagenase inhibitors.
  6. Clark Donald E. (Norristown PA) Grant Norman H. (Wynnewood PA), Inhibitor of mammalian collagenase and elastase.
  7. McGregor William H. (Malvern PA), Mammalian collagenase inhibitors.
  8. Shimazaki Norihiko (Ibaraki JPX) Hemmi Keiji (Ibaraki JPX) Nakaguti Osamu (Toyonaka JPX) Miyazaki Yoshio (Itami JPX) Hashimoto Masashi (Ibaraki JPX), Piperazine compound as PAF-antagonist.
  9. Shimazaki Norihiko (Ibaraki JPX) Hemmi Keiji (Ibaraki JPX) Nakaguti Osamu (Toyonaka JPX) Miyazaki Yoshio (Itami JPX) Hashimoto Masashi (Ibaraki JPX), Piperazine compound as PAF-antagonist.
  10. Donald David K. (High Wycombe GB3) Hann Michael M. (Watlington GB3) Saunders John (Ickford GB3) Wadsworth Harry J. (High Wycombe GB3), Thiol based collagenase inhibitors.
  11. Markwell Roger E. (Harlow GB2) Smith Stephen A. (Harlow GB2) Hughes Ian (Harlow GB2), Thiol carboxylic acid derivatives and their use as collagenase inhibitor.

이 특허를 인용한 특허 (43)

  1. Bar-Or, David; Thomas, Greg, Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same.
  2. Bar Or, David; Bar Or, Raphael, Diagnosis of multiple sclerosis with diketopiperazines.
  3. Albert, Rainer; Dawson, Janet; Ehrhardt, Claus; Wattanasin, Sompong; Weitz-Schmidt, Gabriele; Welzenbach, Karl, Diazacycloalkanedione derivatives.
  4. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Dry deposition of materials for microarrays using matrix displacement.
  5. Bar-Or, David, Implantable medical devices with increased immune tolerance, and methods for making and implanting.
  6. Rao, Nagaraja K. R.; Turner, Stephen, Method of synthesizing diketopiperazines.
  7. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
  8. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
  9. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
  10. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
  11. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
  12. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
  13. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
  14. Bar-Or, David; Curtis, C. Gerald; Rao, Nagaraja K. R.; Thomas, Greg, Method of using diketopiperazines and composition containing them.
  15. Young, Robert Peter, Methods and compositions for assessment of pulmonary function and disorders.
  16. Patel, Dinesh V.; Ngu, Khehyong, Methods for solid-phase synthesis of hydroxylamine compounds and derivatives and combinatorial libraries thereof.
  17. Patel Dinesh V. ; Ngu Khehyong, Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof.
  18. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
  19. Anderson, Norman G.; Anderson, N. Leigh, Microarrays and their manufacture.
  20. Anderson, Norman G.; Anderson, N. Leigh; Braatz, James A., Microarrays and their manufacture.
  21. Anderson,N. Leigh; Anderson,Norman G.; Braatz,James A., Microarrays and their manufacture by slicing.
  22. Boyce, Jim P.; Howbert, J. Jeffry; Tabone, John C., Pharmaceutical uses and synthesis of diketopiperazines.
  23. Deigin, Vladislav I., Substituted piperazin-2,5-diones and their use as multifunctional bioactive compounds.
  24. Deigin, Vladislav I., Substituted piperazin-2,5-diones as multifunctional bioactive compounds.
  25. Bar-Or, David, Therapeutic methods and compounds.
  26. Bar-Or, David, Therapeutic methods and compounds.
  27. Bar-Or, David, Therapeutic methods and compounds.
  28. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
  29. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
  30. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
  31. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
  32. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
  33. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
  34. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
  35. Bar-Or, David; Bar-Or, Raphael; Shimonkevitz, Richard, Treatment of T-cell mediated diseases.
  36. Bar-Or, David; Bar-Or, Raphael; Shimonkovitz, Richard, Treatment of T-cell mediated diseases.
  37. Bar-Or, David; Winkler, James V., Treatment of degenerative joint disease.
  38. Bar-Or, David; Winkler, James V., Treatment of degenerative joint disease.
  39. Bar-Or, David; Winkler, James V., Treatment of degenerative joint disease.
  40. Bar-Or, David; Winkler, James V., Treatment of degenerative joint disease.
  41. Bar-Or, David, Treatment of diseases.
  42. Bar-Or, David, Treatment of diseases.
  43. Bar-Or, David, Treatment of joint conditions.
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