[특허]Non-competitive threshold ligand-receptor assays

[미국특허] Non-competitive threshold ligand-receptor assays 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/53 G01N-033/566 G01N-033/558 G01N-033/543
출원번호	US-0871900 (1997-06-11)
발명자 / 주소	Buechler Kenneth F. Valkirs Gunars E. Anderson Richard R.
출원인 / 주소	Biosite Diagnostics Incorporated
대리인 / 주소	Lyon & Lyon LLP
인용정보	피인용 횟수 : 84 인용 특허 : 28

초록 ▼

Assay methods for performing non-competitive ligand-receptor assays, where said assays provide a sensible result when the target ligand identified by the assay is present at a concentration greater than a defined threshold concentration. The threshold concentration can be selected to be the upper limit of a normal range of values for a target ligand in a sample, so that an assay in accordance with the invention provides a sensible result only when the target ligand is present at elevated levels.

대표청구항 ▼

[ What is claimed is:] [1.] A method for determining the presence or amount of at least one target ligand above a threshold concentration in a fluid sample suspected of containing the target ligand, the target ligand capable of specifically binding to both a ligand receptor and to a ligand receptor conjugate, said ligand receptor conjugate comprising a second ligand receptor coupled to a signal development element, the method comprising:a. creating a reaction mixture by combining an amount of the ligand receptor with a volume of the fluid sample to achieve a concentration of the ligand receptor such that, subsequent to the reaction mixture coming substantially to equilibrium binding conditions, the ligand receptor is capable of specifically binding the threshold concentration of the target ligand in the sample to form a ligand receptor:target ligand complex;b. creating a composition by combining an amount of the ligand receptor conjugate with the reaction mixture to form a ligand receptor conjugate:target ligand complex when the target ligand concentration is greater than the threshold concentration; and,c. detecting the ligand receptor conjugate:target ligand complex formed when the target ligand concentration is greater than the threshold concentration by contacting the composition with a solid phase comprising ligand receptor immobilized thereto to specifically bind the ligand receptor conjugate:target ligand complex, and generating a signal from the signal development element of the bound ligand receptor conjugate:target ligand complex whereby the bound target ligand is determined to be at a concentration greater than the threshold concentration.

이 특허에 인용된 특허 (28) 인용/피인용 타임라인 분석

Self Colin H. (Ealing GBX), Antibodies against the complex of a small molecule and its binding protein, their preparation and their use in diagnosti.
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Buechler Kenneth F. (San Diego CA) Valkirs Gunars E. (Escondido CA), Antibodies to complexes of ligand receptors and ligands and their utility in ligand-receptor assays.
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Deutsch Alice (New York NY) Brandwein Harvey (Port Washington NY) Platt Herbert (Great Neck NY) Hunter Dianne M. (New Rochelle NY) Dubitsky Andrew (Amityville NY) Durham Susan M. (Westbury NY), Antigen assay method and kit.
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Bauman David S. (P.O. Box 1151 Norman OK 73070) Barstad Paul A. (1129 Robinhood La. Norman OK 73701), Assay method and device.
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Weng Litai (Mountain View CA) Calderhead David (Menlo Park CA) Khanna Pyare (San Jose CA) Ullman Edwin F. (Atherton CA), Concentrating immunochemical test device and method.
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Tom Henry K. (La Honda CA) Rowley Gerald L. (Cupertino CA), Concentrating zone method in heterogeneous immunoassays.
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Katz David H. (La Jolla CA) Cooper Steven W. (San Diego CA) Lee Theodore T. (San Diego CA) Chang Shung-Ho (Encinitas CA), Detection of HCG with solid phase support having avidin coating.
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Parikh Indu (Chapel Hill NC) Cuatrecasas Pedro (Chapel Hill NC), Diagnostic reagent.
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Liotta Lance A. (5621 Sonoma Rd. Bethesda MD 20817), Enzyme immunoassay with two-zoned device having bound antigens.
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Lenhoff Howard M. (Costa Mesa CA) Ngo That T. (Irvine CA), Heterogeneous immunoassay method.
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Root David M. (Bedford MA) Cole Francis X. (Stow MA), Immunoassay with membrane immobilized antibody.
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Grubb Anders O. (Lund SEX) Glad Ulla C. (Malmo SEX), Immunoassay with test strip having antibodies bound thereto.
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Zuk Robert F. (Menlo Park CA) Litman David J. (Mountain View CA), Immunochromatographic assay with support having bound “MIP”and second enzyme.
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Rubenstein Kenneth E. (Menlo Park CA) Ullman Edwin F. (Atherton CA), Inhibitable enzyme amplification assay.
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Leuvering Johannes H. W. (Heesch NLX), Metal sol particle immunoassay.
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Valkirs Gunars E. (San Marcos CA) Owen Newton C. (Encinitas CA) Levinson Philip A. (San Diego CA), Method and apparatus for immunoassays.
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Valkirs Gunars E. (San Marcos CA) Owen Newton C. (Encinitas CA) Levinson Philip A. (San Diego CA), Method and apparatus for immunoassays.
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Swanson Melvin J. (Carver MN) Guire Patrick E. (Eden Prairie MN), Quantitative analysis apparatus and method.
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Maggio Edward T. (Redwood City CA) Wife Richard L. (Sittingbourne CA GB2) Ullman Edwin F. (Atherton CA), Reagents and method employing channeling.
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Falkow Stanley (Seattle WA) Moseley Stephen L. (Kirkland WA), Specific DNA probes in diagnostic microbiology.
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Cole Francis X. (Stowe MA) Edwards James H. (Winchester MA) Hendrick Clifford L. (Boxboro MA) VanVoorhis Deborah M. (Watertown MA), Test device.
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Litman David J. (Cupertino CA) Ullman Edwin F. (Atherton CA), Test strip kits in immunoassays and compositions therein.
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Buechler Kenneth F. (San Diego CA) Valkirs Gunars E. (Escondido CA) Anderson Richard R. (Encinitas CA), Threshold ligand-receptor assay.
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Buechler Kenneth F. (Santee CA) Valkirs Gunars E. (Escondido CA) Anderson Richard R. (Encinitas CA), Threshold ligand-receptor assay.
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Buechler Kenneth F. (Santee CA) Valkirs Gunars E. (Escondido CA) Anderson Richard R. (Encinitas CA), Threshold ligand-receptor assay.
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[미국특허] Non-competitive threshold ligand-receptor assays 원문보기

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