초록 ▼

The present invention provides a filter for effectively removing substances from a sample of bodily fluid which can interfere with the results of an assay. The filter includes a solid phase support and an active chemical component for binding to the interfering substance. The active chemical compone

The present invention provides a filter for effectively removing substances from a sample of bodily fluid which can interfere with the results of an assay. The filter includes a solid phase support and an active chemical component for binding to the interfering substance. The active chemical component is insoluble in the sample and is immobilized on the solid phase support. The present invention also includes a filter device, transport matrix, assay device, and method for removing substances which interfere with determining the presence of one or more analytes in a sample.

대표청구항 ▼

[ What is claimed is:] [1.] A transport matrix for removing one or more substances which interfere with determining the presence of an analyte in an immunoassay sample of physiological fluid, the transport matrix adapted for use in a sealed housing of an immunoassay device, the transport matrix comp

[ What is claimed is:] [1.] A transport matrix for removing one or more substances which interfere with determining the presence of an analyte in an immunoassay sample of physiological fluid, the transport matrix adapted for use in a sealed housing of an immunoassay device, the transport matrix comprising:a sample receptor zone configured to receive the sample of physiological fluid directly on the matrix;a detection zone having an immunoassay reagent yielding a physically detectable change which correlates with the amount of selected analyte in the sample to provide a quantitative immunoassay result within the housing, the detection zone being in fluid communication by capillary action with the sample receptor zone; andan active chemical component including silver or lead is immobilized by chemically binding on the transport matrix prior to the detection zone, the active chemical component having an affinity for binding to and immobilizing the interfering substance, the active chemical component being insoluble in the sample of physiological fluid.