초록 ▼

A pharmaceutical multiple unit particulate formulation in the form of coated cores which includes a pharmaceutically acceptable carrier selected from calcium carbonate, calcium silicate, calcium magnesium silicate, calcium phosphate, kaolin, sodium hydrogen carbonate, sodium sulfate, barium carbonat

A pharmaceutical multiple unit particulate formulation in the form of coated cores which includes a pharmaceutically acceptable carrier selected from calcium carbonate, calcium silicate, calcium magnesium silicate, calcium phosphate, kaolin, sodium hydrogen carbonate, sodium sulfate, barium carbonate, barium sulfate, magnesium sulfate, magnesium carbonate, and activated carbon, and an active substance in a layer on the outer surface of the cores.

대표청구항 ▼

[ We claim:] [1.] A pharmaceutical multiple unit particulate formulation comprising individual units in the form of coated cores, wherein at least 50% w/w of the cores before coating have a particle size within a range of about 90-225 .mu.m, when tested as described herein, each coated core comprisi

[ We claim:] [1.] A pharmaceutical multiple unit particulate formulation comprising individual units in the form of coated cores, wherein at least 50% w/w of the cores before coating have a particle size within a range of about 90-225 .mu.m, when tested as described herein, each coated core comprisingi) a pharmaceutically acceptable inert carrier which is present in the core in a first concentration of at least about 20% w/w calculated on the total weight of the core, and which is selected from the group consisting of calcium carbonate, calcium silicate, calcium magnesium silicate, calcium phosphate, kaolin, sodium hydrogen carbonate, sodium sulfate, barium carbonate, barium sulfate, magnesium sulfate, magnesium carbonate, and activated carbon, andii) an active drug substance being present in a layer on the outer surface of the cores,the pharmaceutically acceptable inert carrier being such a material which--when formulated into uncoated cores containing the pharmaceutically acceptable inert carrier optionally in combination with a binder and with a second concentration of the inert carrier of at least 80% w/w calculated on the total weight of the uncoated core--has a friability (weight loss in % w/w) of at the most about 20%, when tested as described herein, and the cores have a flow angle--when tested according to method A described herein using a diameter of the disc outlet of 9 mm--of at the most 30.degree..