$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Compositions and methods for delivery of genetic material 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/70
  • A61K-045/05
출원번호 US-0704701 (1996-09-16)
국제출원번호 PCT/US95/04071 (1995-03-30)
§371/§102 date 19960916 (19960916)
국제공개번호 WO-9526718 (1995-10-12)
발명자 / 주소
  • Carrano Richard A.
  • Wang Bin,CNX
  • Weiner David B.
출원인 / 주소
  • The Trustees Of The University of Pennsylvania
대리인 / 주소
    Woodcock Washburn Kurtz Mackiewcz & Norris LLP
인용정보 피인용 횟수 : 67  인용 특허 : 11

초록 ▼

Methods of introducing genetic material into cells of an individual and compositions and kits for practicing the same are disclosed. The methods comprise the steps of contacting cells of an individual with a genetic vaccine facilitator and administering to the cells a nucleic acid molecule that is f

대표청구항 ▼

[ We claim:] [1.] A method of generating an immune response in an individual against an antigen comprising administering in vivo to muscle or skin of said individual's body a genetic vaccine facilitator selected from the group consisting of: anionic lipids; saponins; lectins; estrogenic compounds; h

이 특허에 인용된 특허 (11)

  1. Felgner Philip L. (Rancho Santa Fe CA) Kumar Raj (San Diego CA) Basava Channa (San Diego CA) Border Richard C. (Poway CA) Hwang-Felgner Jiin-Yu (Rancho Santa Fe CA), Cationic lipids for intracellular delivery of biologically active molecules.
    상세보기
  2. Green Christopher J. (Menlo Park CA) Johnson Paul H. (Menlo Park CA), Cloning and expression of a variant gene of platelet factor 4 and compositions thereof to modulate immune responses.
    상세보기
  3. Morgan ; Jr. A. Charles (Edmonds WA) Woodhouse Clive S. (Seattle WA) McIntyre Robert F. (Seattle WA), Enhanced production of antibodies utilizing insolubilized immune complexes.
    상세보기
  4. Weiner David B. (Merion PA) Williams William V. (Havertown PA) Wang Bin (Havertown PA), Genetic immunization.
    상세보기
  5. Sanford John C. (Geneva NY) Wolf Edward D. (Ithaca NY) Allen Nelson K. (Newfield NY), Method for transporting substances into living cells and tissues and apparatus therefor.
    상세보기
  6. Szoka ; Jr. Francis C. (76 Summit St. Waltham MA 02154) Papahadjopoulos Demetrios P. (3170 Condit St. Lafayette CA 94549), Method of inserting DNA into living cells.
    상세보기
  7. Kensil Charlotte A. (Milford MA) Soltysik Sean (Worcester MA) Marciani Dante J. (Hopkinton MA), Methods for enhancing drug delivery with modified saponins.
    상세보기
  8. Eppstein Deborah A. (Menlo Park CA) Felgner Philip L. (Los Altos CA) Gadek Thomas R. (Oakland CA) Jones Gordon H. (Cupertino CA) Roman Richard B. (Fairhope AL), N-www 상세보기
  • Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
    상세보기
  • Hseih Dean (Brandamore PA), Transdermal and trans-membrane delivery of drugs.
    상세보기
  • Gerber Jay D. (Lincoln NE), Vaccine formulation.
    상세보기

    • 이 특허를 인용한 특허 (67)

    1. Wimer-Mackin, Susan, Anthrax antigens and methods of use.
      상세보기
    2. Draghia-Akli, Ruxandra; Khan, Amir S., Antibody production elicited by a DNA vaccine delivered by electroporation.
      상세보기
    3. Carrano Richard A. ; Wang Bin,CNX ; Weiner David B., Compositions and methods for delivery of genetic material.
      상세보기
    4. Manthorpe, Marston; Hartikka, Jukka; Sukhu, Loretta; Meek, Jennifer, Compositions and methods for in vivo delivery of polynucleotide-based therapeutics.
      상세보기
    5. Perez-Pinera, Pablo; Gersbach, Charles, Compositions and methods for the induction and tuning of gene expression.
      상세보기
    6. Aguilar Rubido,Julio C��sar; Palenzuela Gard��n,Daniel O.; Muzio Gonz��lez,Verena L.; Guill��n Nieto,Gerardo E.; Pent��n Arias,Eduardo; Pichardo D��az,Dagmara; Iglesias Perez,Enrique, Compositions containing virus-like particles as immunopotentiators administered through the mucosa.
      상세보기
    7. Weiner, David B; Kutzler, Michele, Compositions for and methods of inducing mucosal immune responses.
      상세보기
    8. Weiner, David B.; Yan, Jian; Ferraro, Bernadette; Sardesai, Niranjan Y.; Ramanathan, Mathura P., Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same.
      상세보기
    9. Weiner, David B; Yan, Jian; Ferraro, Bernadette; Sardesai, Niranjan Y; Ramanathan, Mathura P, Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same.
      상세보기
    10. Weiner, David; Yan, Jian; Ferraro, Bernadette; Sardesai, Niranjan Y.; Ramanathan, Mathura P., Consensus prostate antigens, nucleic acid molecule encoding the same and vaccine and uses comprising the same.
      상세보기
    11. Weiner, David B.; Muthumani, Karuppiah, Consensus sequences of chikungunya viral proteins, nucleic acid molecules encoding the same, and compositions and methods for using the same.
      상세보기
    12. Weiner, David B.; Sin, Jeong-Im; Zhang, Donghui, Cosmid DNA constructs and methods of making and using same.
      상세보기
    13. Simard, John J. L.; Diamond, David C.; Qiu, Zhiyong; Lei, Xiang-Dong, Expression vectors encoding epitopes of target-associated antigens and methods for their design.
      상세보기
    14. Simard, John J. L.; Diamond, David C.; Qiu, Zhiyong; Lei, Xiang-Dong, Expression vectors encoding epitopes of target-associated antigens and methods for their design.
      상세보기
    15. Simard,John J. L.; Diamond,David C.; Qiu,Zhiyong; Lei,Xiang Dong, Expression vectors encoding epitopes of target-associated antigens and methods for their design.
      상세보기
    16. Weiner, David B.; Yan, Jian; Muthumani, Karuppiah; Sardesai, Niranjan Y., Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom.
      상세보기
    17. Weiner, David B; Ferraro, Bernadette; Yan, Jian; Brown, Patricia A; Bowling, Rodney A; Kern, Douglas R; Ramanathan, Mathura P; Sardesai, Niranjan Y; Muthumani, Karuppiah, Foot and mouth disease virus (FMDV) consensus proteins, coding sequences therefor and vaccines made therefrom.
      상세보기
    18. Gersbach, Charles; Ousterout, David, Genetic correction of mutated genes.
      상세보기
    19. Weiner, David B.; Lang, Krystle A.; Yan, Jian; Draghia-Akli, Ruxandra; Khan, Amir, HCV vaccines and methods for using the same.
      상세보기
    20. Weiner, David B; Kuhs, Krystle A. Lang; Yan, Jian; Draghia-Akli, Ruxandra; Khan, Amir, HCV vaccines and methods for using the same.
      상세보기
    21. Weiner, David B; Lang, Krystle; Yan, Jian; Draghia-Akli, Ruxandra; Khan, Amir S, HCV vaccines and methods for using the same.
      상세보기
    22. Cheever, Martin A.; Gheysen, Dirk, HER-2/neu fusion proteins.
      상세보기
    23. Cheever,Martin A.; Gheysen,Dirk, HER-2/neu fusion proteins.
      상세보기
    24. Cheever,Martin A.; Gheysen,Dirk, HER-2/neu fusion proteins.
      상세보기
    25. Weiner, David B.; Yan, Jian, HIV consensus envelope sequences and methods for using the same.
      상세보기
    26. Weiner, David B; Yan, Jian; Laddy, Dominick, HIV consensus envelope sequences and methods for using the same.
      상세보기
    27. Weiner, David B; Yan, Jian, HPV vaccines and methods for using the same.
      상세보기
    28. Cheever,Martin A.; Gheysen,Dirk, Her-2/neu fusion proteins.
      상세보기
    29. Weiner, David B.; Yang, Joo-Sung, Highly expressible genes.
      상세보기
    30. Weiner, David B.; Morrow, Matthew P.; Yan, Jian, Influenza nucleic acid molecules and vaccines made therefrom.
      상세보기
    31. Weiner, David B; Morrow, Matthew P; Yan, Jian, Influenza nucleic acid molecules and vaccines made therefrom.
      상세보기
    32. Weiner, David B; Yan, Jian; Morrow, Matthew P, Influenza nucleic acid molecules and vaccines made therefrom.
      상세보기
    33. Simard, John J. L.; Diamond, David C., Method of epitope discovery.
      상세보기
    34. K?ndig, Thomas M.; Simard, John J. L., Method of inducing a CTL response.
      상세보기
    35. Kundig,Thomas M.; Simard,John L., Method of inducing a CTL response.
      상세보기
    36. Kündig, Thomas M.; Simard, John J. L., Method of inducing a CTL response.
      상세보기
    37. K��ndig,Thomas M.; Simard,John J. L., Method of inducing a CTL response.
      상세보기
    38. Pachuk, Catherine J., Methods and compositions for silencing genes without inducing toxicity.
      상세보기
    39. Weiner, David B; Yan, Jian; Obeng-Adjei, Nyamekye, Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same.
      상세보기
    40. Weiner, David B; Yan, Jian; Obeng-Adjei, Nyamekye, Nucleic acid molecule encoding hepatitis B virus core protein and surface antigen protein and vaccine comprising the same.
      상세보기
    41. Weiner, David B.; Yan, Jian; Obeng-Adjei, Nyamekye, Nucleic acid molecule encoding hepatitis B virus core protein and vaccine comprising the same.
      상세보기
    42. Weiner, David; Yan, Jian; Obeng-Adjei, Nyamekye, Nucleic acid molecule encoding hepatitis B virus core protein and vaccine comprising the same.
      상세보기
    43. Weiner, David B; Shedlock, Devon, Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof.
      상세보기
    44. Weiner, David B; Shedlock, Devon J, Nucleic acid molecules encoding novel herpes antigens, vaccine comprising the same, and methods of use thereof.
      상세보기
    45. Weiner, David B; Boyer, Jean D; Kutzler, Michele, Nucleic acid molecules encoding rantes, and compositions comprising and methods of using the same.
      상세보기
    46. Weiner, David B.; Kutzler, Michele; Choo, Andrew Y.; Yang, Joo-Sung; Boyer, Jean D., Nucleic acid sequences encoding and compositions comprising IgE signal peptide and/or IL-15 and methods for using the same.
      상세보기
    47. Long, Deborah; Flechtner, Jessica; Skoberne, Mojca, Nucleic acid vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response.
      상세보기
    48. Min Byung-Moo,KRX, Pharmaceutical composition, containing medium-chain fatty acids as active ingredients, for dental caries and periodontal disease.
      상세보기
    49. O'Hagan, Derek; Lavelle, Edward C., Plant lectins as mucosal adjuvants.
      상세보기
    50. Draghia-Akli, Ruxandra; Prigge, Jon; Sardesai, Niranjan Y.; Weiner, David B.; Hirao, Lauren A., Smallpox DNA vaccine and the antigens therein that elicit an immune response.
      상세보기
    51. Long, Deborah; Flechtner, Jessica; Skoberne, Mojca, Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response.
      상세보기
    52. Long, Deborah; Flechtner, Jessica; Skoberne, Mojca; Siber, George R., Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response.
      상세보기
    53. Long, Deborah; Flechtner, Jessica; Skoberne, Mojca; Siber, George R., Vaccines against herpes simplex virus type 2: compositions and methods for eliciting an immune response.
      상세보기
    54. Draghia-Akli, Ruxandra; Weiner, David B.; Yan, Jian; Laddy, Dominick, Vaccines against multiple subtypes of influenza virus.
      상세보기
    55. Draghia-Akli, Ruxandra; Weiner, David B.; Yan, Jian; Laddy, Dominick, Vaccines against multiple subtypes of influenza virus.
      상세보기
    56. Draghia-Akli, Ruxandra; Weiner, David B; Yan, Jian; Laddy, Dominick J, Vaccines against multiple subtypes of influenza virus.
      상세보기
    57. Weiner, David B.; Kraynyak, Kimberly A.; Kutzler, Michele, Vaccines and immunotherapeutics comprising IL-15 receptor alpha and/or nucleic acid molecules encoding the same, and methods for using the same.
      상세보기
    58. Weiner, David B.; Morrow, Mathew P., Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same.
      상세보기
    59. Weiner, David B; Morrow, Matthew P, Vaccines and immunotherapeutics using IL-28 and compositions and methods of using the same.
      상세보기
    60. Weiner, David B.; Kutzler, Michele, Vaccines and immunotherapeutics using codon optimized IL-15 and methods for using the same.
      상세보기
    61. Weiner, David B; Kutzler, Michele, Vaccines and immunotherapeutics using codon-optimized IL-15 and methods for using the same.
      상세보기
    62. Weiner, David B.; Lang-Kuhs, Krystle A.; Yan, Jian; Draghia-Akli, Ruxandra; Khan, Amir S., Vaccines and methods for using the same.
      상세보기
    63. Weiner, David B; Yan, Jian, Vaccines for human papilloma virus and methods for using the same.
      상세보기
    64. Weiner, David B; Yan, Jian, Vaccines for human papilloma virus and methods for using the same.
      상세보기
    65. Levinson, Arnold I.; Calarota, Sandra; Weiner, David B.; Otero, Miguel, Vaccines for suppressing IgE-mediated allergic disease and methods for using the same.
      상세보기
    66. Weiner, David B.; Kim, Jong J.; Sin, Jeong-Im, Vaccines, immunotherapeutics and methods for using the same.
      상세보기
    67. Weiner, David B.; Yan, Jian, hTERT sequences and methods for using the same.
      상세보기

    관련 콘텐츠

    섹션별 컨텐츠 바로가기

    AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

    AI-Helper 아이콘
    AI-Helper
    안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
    ※ AI-Helper는 부적절한 답변을 할 수 있습니다.

    선택된 텍스트

    맨위로