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[미국특허] Oligonucleotide N3'.fwdarw.P5' phosphoramidates 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
출원번호 US-0700448 (1997-01-10)
국제출원번호 PCT/US95/03575 (1995-03-20)
§371/§102 date 19970110 (19970110)
국제공개번호 WO-9525814 (1995-09-28)
발명자 / 주소
  • Gryaznov Sergei M.
  • Schultz Ronald G.
  • Chen Jer-kang
출원인 / 주소
  • Lynx Therapeutics, Inc.
대리인 / 주소
    Macevicz
인용정보 피인용 횟수 : 205  인용 특허 : 3

초록 ▼

Modified oligonucleotides 3'-NHP(O)(O.sup.-)O-5' phosphoramidates were synthesized on a solid phase support. The phosphoramidate analogs were found to have significantly increased resistance toward phosphodiesterase digestion. Thermal dissociation experiments demonstrated that these compounds form m

대표청구항 ▼

[ It is claimed:] [1.] An oligodeoxyribonucleotide comprising a non-homopolymeric defined sequence of nucleoside subunits joined by intersubunit linkages wherein at least fifty percent of such intersubunit linkages are N3'.fwdarw.P5' phosphoramidate linkages, and at least two of said N3'.fwdarw.P5'

이 특허에 인용된 특허 (3) 인용/피인용 타임라인 분석

  1. Calabretta Bruno ; Skorski Tomasz, Antisense oligonucleotides targeting cooperating oncogenes.
    상세보기
  2. Letsinger Robert L. (Wilmette IL) Gryaznov Sergei M. (San Mateo CA), Oligodeoxyribonucleotides including 3′-aminonucleoside-phosphoramidate linkages and terminal 3′-amino groups.
    상세보기
  3. Gryaznov Sergei M. (San Mateo CA) Schultz Ronald G. (Fremont CA) Chen Jer-Kang (Palo Alto CA), Oligonucleotide N3′→P5′phosphoramidates: hybridization and nuclease resistance properties.
    상세보기

이 특허를 인용한 특허 (205) 인용/피인용 타임라인 분석

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