초록 ▼

A transport matrix and diagnostic device are provided which produce a physically detectable change in a predetermined distribution across a detection zone which correlates with the amount of selected analyte in a sample. The matrix includes a detection zone having a capture reagent yielding a physic

A transport matrix and diagnostic device are provided which produce a physically detectable change in a predetermined distribution across a detection zone which correlates with the amount of selected analyte in a sample. The matrix includes a detection zone having a capture reagent yielding a physically detectable change which correlates with the amount of selected analyte in the sample. The detection zone has a leading boundary which first encounters the sample and a trailing boundary which encounters the sample after being transported across the detection zone. The capture reagent is immobilized on the matrix in a predetermined distribution from the leading boundary to the trailing boundary of the detection zone. A method is also provided which determines the level of a selected analyte in a sample by distributing a physically detectable change in a predetermined pattern across a detection zone on a transport matrix which correlates with the amount of selected analyte.

대표청구항 ▼

[ What is claimed is:] [1.] A transport matrix producing a physically detectable change in a predetermined distribution across a detection zone which correlates with the amount of selected analyte in a sample, the matrix comprising;a detection zone having a capture reagent yielding a physically dete

[ What is claimed is:] [1.] A transport matrix producing a physically detectable change in a predetermined distribution across a detection zone which correlates with the amount of selected analyte in a sample, the matrix comprising;a detection zone having a capture reagent yielding a physically detectable change which correlates with the amount of selected analyte in the sample, the detection zone being defined by an area in which the physical detectable change is sampled, the detection zone having a leading boundary which first encounters the sample and a trailing boundary which encounters the sample after being transported across the detection zone, the capture reagent being immobilized on the matrix in a varied, predetermined distribution from the leading boundary to the trailing boundary of the detection zone so that the physical detectable change has a substantially uniform distribution in the direction of the sample flow, the predetermined distribution of immobilized capture region being a plurality of deposits of the capture reagent, the density of the plurality of deposits increasing from the leading boundary to the trailing boundary of the detection zone.