초록 ▼

The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through t

The present invention generally provides microfluidic devices which incorporate improved channel and reservoir geometries, as well as methods of using these devices in the analysis, preparation, or other manipulation of fluid borne materials, to achieve higher throughputs of such materials through these devices, with lower cost, material and/or space requirements.

대표청구항 ▼

[ We claim:] [1.] A microfluidic system, comprising:a planar substrate having a first surface;an analysis channel disposed in said substrate;a sample loading channel disposed in said substrate and in fluid communication and crossing said analysis channel at a first intersection;a plurality of separa

[ We claim:] [1.] A microfluidic system, comprising:a planar substrate having a first surface;an analysis channel disposed in said substrate;a sample loading channel disposed in said substrate and in fluid communication and crossing said analysis channel at a first intersection;a plurality of separate sample sources in fluid communication with said sample loading channel, whereby there is at least one of said plurality of separate sample sources in fluid communication with said sample loading channel on each side of said first intersection; andfirst and second load/waste channels disposed in said substrate, each of said first and second load/waste channels intersecting said sample loading channel at second and third intersections, respectively, said second and third intersections being on different sides of said first intersection. [70.] A method of analyzing a plurality of different sample materials, comprising:providing a microfluidic device which comprises:a planar substrate having a first surface;an analysis channel disposed in said substrate;a sample loading channel disposed in said substrate and intersecting said analysis channel at a first intersection, wherein said sample loading channel crosses said analysis channel; andat least first and second sample sources in fluid communication with said sample loading channel;a waste reservoir in fluid communication on a same side of said first intersection as said second sample source;transporting a first sample from a first of said plurality of sample sources, through said sample loading channel to said first intersection;injecting a portion of said first sample into said analysis channel;analyzing said first sample in said analysis channel;transporting said second sample through said sample loading channel and into said waste reservoir; andinjecting a portion of said second sample into said analysis channel.