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Methods for fabricating polymer-based controlled release devices 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • B01J-013/02
  • B01J-013/04
  • A61K-009/22
출원번호 US-0935452 (1997-09-24)
발명자 / 주소
  • Tracy Mark A.
  • Herberger John D.
  • Burke Paul A.
  • Herbert Paul F.
출원인 / 주소
  • Alkermes Controlled Therapeutics, Inc.
대리인 / 주소
    Hamilton, Brook, Smith & Reynolds, P.C.
인용정보 피인용 횟수 : 188  인용 특허 : 26

초록 ▼

The present invention relates to a polymer-based sustained release device, and methods of forming and using the device for the sustained release of an active agent. The improved method of the invention for forming a polymer-bases sustained release device comprises forming a polymer/active agent solu

대표청구항 ▼

[ What is claimed is:] [1.] A method of forming a polymer-based sustained release device comprising the steps of:a) forming a polymer/biologically active agent solution by mixing a polymer, a continuous phase comprising one or more polymer solvents and a biologically active agent wherein the polymer

이 특허에 인용된 특허 (26)

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  6. Zale Stephen E. (Hopkington MA) Burke Paul A. (Medford MA) Bernstein Howard (Cambridge MA) Brickner Avram (Brookline MA), Composition for sustained release of non-aggregated erythropoietin.
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  8. Tice Thomas R. (Birmingham AL) Lewis Danny H. (Gardendale AL) Cowsar Donald R. (Birmingham AL) Beck Lee R. (Birmingham AL), Injectable, long-acting microparticle formulation for the delivery of anti-inflammatory agents.
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  10. Igari Yasutaka (Hyogo JPX) Saikawa Akira (Osaka JPX) Okamoto Kayoko (Osaka JPX) Kamei Shigeru (Hyogo JPX) Oka Masahisa (Kanagawa JPX) Sano Atsunori (Saitama JPX), Matrix for sustained-release preparation.
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  11. Kobayashi Masao (Kyoto JPX) Nishioka Yukiko (Toyonaka JPX) Suzuki Takehiko (Toyono-gun JPX) Matsukawa Yashuhisa (Osaka JPX), Method for producing sustained release microsphere preparation.
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  12. Kent John S. (Cupertino CA) Lewis Danny H. (Birmingham AL) Sanders Lynda M. (Palo Alto CA) Tice Thomas R. (Birmingham AL), Microencapsulation of water soluble active polypeptides.
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  13. Tice Thomas R. (Helena AL) Lewis Danny H. (Gardendale AL), Microencapsulation process.
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  14. Wantier Henri (Dour BEX) Mathieu Fabienne (Nivelles BEX) Baudrihaye Marc (Waterloo BEX) Delacroix Dominique (Kraainem BEX), Microspheres for the controlled release of water-soluble substances and process for preparing them.
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  15. Bernstein Howard (Cambridge MA) Zhang Yan (Cambridge MA) Khan M. Amin (Downingtown PA) Tracy Mark A. (Arlington MA), Modulated release from biocompatible polymers.
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  16. Wunderlich Jens-Christian (Heidelberg DEX) Schick Ursula (Wiesloch DEX) Freidenreich Jurgen (Schriesheim DEX) Werry Jurgen (Ludwigshafen DEX), Pellets containing plant extracts, process of making same and their pharmaceutical peroral or cosmetic use.
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  17. Yamamoto Masaki (Osaka JPX) Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Miyagawa Tsutomu (Saitama JPX), Polymer, production and use thereof.
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  18. DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
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  19. Ramstack J. Michael (Lebanon OH) Herbert Paul F. (Wayland MA) Strobel Jan (Westchester OH) Atkins Thomas J. (Cincinnati OH), Preparation of biodegradable microparticles containing a biologically active agent.
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  20. Wantier Henri (Dour BEX) Mathieu Fabienne (Nivelles BEX) Baudrihaye Marc (Waterloo BEX) Delacroix Dominique (Kraainem BEX), Preparation of microparticles for controlled release of water-soluble substances.
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  21. Tice Thomas R. (Birmingham AL) Orsolini Piero (Martigny LA CHX) Schally Andrew V. (New Orleans LA), Process for increasing the antagonistic effect of peptidic compounds on hormone-dependent diseases.
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  22. Billot Genevieve B. (Lyons FRX) Teichner Marc M. (Sainte Foy Les Lyon FRX), Process for preparing microspheres for the prolonged release of the LHRH hormone and its analogues, microspheres and for.
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  23. Fong Jones W. (Parsippany NJ), Processes for preparation of microspheres.
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  24. Lokensgard David M. (San Jose CA), Solvent extraction process.
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  25. Orsolini Piero (Martigny) Mauvernay Rolland-Yves (Lausanne) Deghenghi Romano (Lausanne CHX), Sustained and controlled release of water insoluble polypeptides.
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  26. Gombotz Wayne R. (Lexington MA) Healy Michael S. (E. Bridgewater MA) Brown Larry R. (Newton MA), Very low temperature casting of controlled release microspheres.
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