Stable solution of zinc ions and bicarbonate and/or carbonate ions
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-007/16
A61K-007/36
A61K-031/315
A61K-033/30
출원번호
US-0222101
(1998-12-29)
발명자
/ 주소
Yam Benny S.
출원인 / 주소
Church & Dwight Co., Inc.
대리인 / 주소
Fishman
인용정보
피인용 횟수 :
26인용 특허 :
22
초록▼
A storage stable aqueous solution or aqueous gel of zinc ions in the presence of bicarbonate ions is disclosed. The solution comprises: (a) a source of zinc ion, (b) a source of a stabilizing anion which can stabilize soluble zinc and bicarbonate and/or carbonate in solution; (c) a source of bicarbo
A storage stable aqueous solution or aqueous gel of zinc ions in the presence of bicarbonate ions is disclosed. The solution comprises: (a) a source of zinc ion, (b) a source of a stabilizing anion which can stabilize soluble zinc and bicarbonate and/or carbonate in solution; (c) a source of bicarbonate ion; and (d) a solvent therefor. The solvent comprises a major proportion of water. The zinc salt is present in an amount suitable for the intended purpose; the stabilizing anion in an amount B of at least 1.2 equivalents per equivalent of zinc ion; and the bicarbonate ion cannot exceed certain levels which are related to the level of the stabilizing anion.
대표청구항▼
[ I claim:] [1.] A storage clarity-stable aqueous or aqueous/alcoholic solution of zinc ions in the presence of at least one of bicarbonate and carbonate ions comprising:(a) a zinc salt of a first anion which salt is selected from the group consisting of(i) salts of zinc with one or more of said fir
[ I claim:] [1.] A storage clarity-stable aqueous or aqueous/alcoholic solution of zinc ions in the presence of at least one of bicarbonate and carbonate ions comprising:(a) a zinc salt of a first anion which salt is selected from the group consisting of(i) salts of zinc with one or more of said first anion, including mixed first anion salts thereof, said first anion being selected from the group consisting of(1) chloride, sulfate, monophosphate, pyrophosphate, metaphosphate, tripolyphosphate, tettametaphosphate, orthophosphate, and(2) organic carboxylic acid anions selected from the group consisting of gluconate, tartrate, fumarate, maleate, malonate, malate, lactate, citrate, EDTA, citraconate, citramalate, stearate, oleate, laurate, octoate ascorbate, picolinate, and orotate, and(ii) salts of mixed alkali metal zinc or mixed magnesium zinc with said first anion;(b) a salt of a first metal and a second anion; said first metal being selected from the group consisting of alkali metals and magnesium; and said second anion being selected from the group consisting of(i) carboxylic acids selected from the group consisting of tartrate, funarate, maleate, malonate, malate, citraconate, citramalate, lactate, citrate, and EDTA, and(ii) phosphates selected from the group consisting of pyrophosphate and tripolyphosphate;(c) at least one compound selected from the group consisting of alkali metal bicarbonates, alkali metal carbonates, magnesium bicaarbonate, and magnesium carbonate;(d) a solvent therefor, said solvent comprising:(i) a major proportion of water;(ii) optionally a minor amount of a lower alkyl monohydric alcohol; and(iii) optionally a minor amount of a humectant having at least 3 hydroxy groups;(e) optionally one or more acceptable antibacterial agents;(f) optionally one or more acceptable viscosity enhancers;(g) optionally one or more sweeteners;(h) optionally one of more flavors;(i) optionally one or more colors; and(j) optionally one or more acceptable fragrances;said zinc salt being present in an amount A sufficient to yield a zinc ion concentration of from about 0.01 to about 2 weight %;said salt of said second anion present in an amount B, which in combination with any of said second anion present from other components of said solution, is sufficient to provide a total second anion concentration of at least 1.2 equivalents per equivalent of zinc ion;said compound being present in an amount of C equivalents, which is no greater than the sum of(a) (6).times.(the number of equivalents of said pyrophosphate and tripolyphosphate); and(b) {(3.sup.(n-1))/(2.sup.m)}.times.(the number of equivalents of said second anions which are carboxylic acids), where n is the number of carboxyl groups and m is the number of basic nitrogens;whereby the interaction of solubilized zinc ions and solubilized bicarbonate and carbonate ions to form insoluble zinc carbonate(s) is substantially reduced relative to that which would occur in the same formulation in the absence of said second anion in the amounts set forth above.
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