Ingestible compounds which are substantially tasteless and which have been found to be effective reducers or eliminators of undesirable tastes for eatables.
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[ What is claimed is:] [1.] An eatable composition comprising a sweetener which imparts an undesirable taste to the eatable, and at least one tastand in a substantially tasteless amount of from about 0.0000001 to about 300% by weight, based on the weight of the eatable, which amount is sufficient to
[ What is claimed is:] [1.] An eatable composition comprising a sweetener which imparts an undesirable taste to the eatable, and at least one tastand in a substantially tasteless amount of from about 0.0000001 to about 300% by weight, based on the weight of the eatable, which amount is sufficient to reduce said undesirable taste, said tastand being selected from the group consisting of compounds which are substantially tasteless in the amount used and have the structure V-1: [ STR 97 ] wherein a, r, l, and m are 0 or 1; n, j, and k are 0, 1, 2, or 3; each R.sup.2 and R.sup.3, which may be the same or different, is independently selected from the group consisting of H, alkyl, substituted alkyl, alkylene, substituted alkylene, branched alkyl, substituted branched alkyl, branched alkylene, substituted branched alkylene, aryl, substituted aryl, aralkyl, substituted aralkyl, cycloalkyl, substituted cycloalkyl, acyl, substituted acyl, benzoyl, substituted benzoyl, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, trifluoromethyl, halogen, cyano, heterocyclic, substituted heterocyclic, polycyclic, and substituted polycyclic; each Y, which may be the same or different, is independently selected from the group consisting of N, O, and S; when r is 1 and Y is N, p is 2 or 3; when m is 1 and Y is N, q is 2 or 3; when r is 1 and Y is O, p is 1; when m is 1 and Y is O, q is 1; when r is 1 and Y is S, p is 1 or 2; when m is 1 and Y is S, q is 1 or 2; A is selected from the group consisting of H, C.dbd.O, O.dbd.S.dbd.O, S.dbd.O, O.dbd.P(H)OH, O.dbd.P(OH).sub.2, and O.dbd.B(H)OH; Q is selected from the group consisting of H, alkyl, substituted alkyl, alkylene, substituted alkylene, branched alkyl, substituted branched alkyl, branched alkylene, substituted branched alkylene, aryl, substituted aryl, aralkyl, substituted aralkyl, cycloalkyl, substituted cycloalkyl, acyl, substituted acyl, benzoyl, substituted benzoyl, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, trifluoromethyl, halogen, cyano, heterocyclic, substituted heterocyclic, polycyclic, and substituted polycyclic; each R, which may be the same or different when p>1, and each R', which may be the same or different when q>1, is independently selected from the group consisting of H, alkyl, substituted alkyl, dialkyl, substituted dialkyl, aralkyl, substituted aralkyl, aryl, substituted aryl, diaryl, substituted diaryl, acyl, substituted acyl, cycloalkyl, substituted cycloalkyl, benzoyl, substituted benzoyl, trifluoroacetyl, alkyloxycarbonyl, substituted alkyloxycarbonyl, aryloxycarbonyl, substituted aryloxycarbonyl, alkylaminocarbonyl, substituted alkylaminocarbonyl, arylaminocarbonyl, substituted arylaminocarbonyl, amidines, substituted amidines, alkylamidines, substituted alkylamidines, arylamidines, substituted arylamidines, monosaccharide, substituted monosaccharide, disaccharide, substituted disaccharide, trisaccharide, substituted trisaccharide, oligosaccharide, substituted oligosaccharide, phosphorylated saccharides, substituted phosphorylated saccharides, arylacyl, substituted arylacyl, alkylene, substituted alkylene, heterocyclic, substituted heterocyclic, polycyclic, substituted polycyclic and the following three structures V-2: [ STR 98 ] wherein b, c and d are 0 or 1; f is 0, 1, 2, 3, 4, 5., 6, 7, 8, 9, 10; each Y as is defined above; when d is 1 and b is 0 and Y is N, e is 2 or 3; when d is 1 and b is 0 and Y is O, e is 1; when d is 1 and b is 0 and Y is S, e is 1 or 2; A is as defined above; Q is selected from the group consisting of H, alkyl, substituted alkyl, alkylene, substituted alkylene, branched alkyl, substituted branched alkyl, branched alkylene, substituted branched alkylene, aryl, substituted aryl, aralkyl, substituted aralkyl, cycloalkyl, substituted cycloalkyl, acyl, substituted acyl, benzoyl, substituted benzoyl, alkoxy, substituted alkoxy, aryloxy, substituted aryloxy, trifluoromethyl, halogen, cyano, heterocyclic, substituted heterocyclic, polycyclic, substituted polycyclic; R'" and Q together may form a cyclic structure; any of the R.sup.3 's and Q together may form a cyclic structure; any of the R.sup.3 's and R'"'s together may form a cyclic structure; Z and Z' may be the same or different and are independently selected from OH, --O.sup.- X.sup.+, OR", NH.sub.2, NHR", N(R").sub.2' ; R" is selected from alkyl, branched alkyl, aryl, aralkyl, alkaryl, cycloalkyl, substituted alkyl, substituted cycloalkyl substituted aryl, substituted aralkyl, substituted alkaryl; R'" is selected from alkyl, branched alkyl, aryl, aralkyl, alkaryl, cycloalkyl, substituted alkyl, substituted cycloalkyl, substituted aryl, substituted aralkyl, substituted alkaryl, and an amino acid side chain; where CH--CH or CH.sub.2 --CH.sub.2 bonds exist the level of unsaturation may be increased by removing one or more hydrogen atoms from each carbon atom participating in the CH--CH or CH.sub.2 --CH.sub.2 bonds; X.sup.+ is selected from H.sup.+ or a physiologically acceptable cation; and physiologically acceptable salts of any of the foregoing compounds.
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이 특허에 인용된 특허 (12)
Kurtz Robert J. (New York NY) Fuller William D. (San Diego CA), Eatable taste modifiers.
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Radhakrishna, Harish; Brown, Michael D.; Siderovski, David Peter; Kimple, Adam; Cohen, Staci Padove, Methods of using lung or bronchial epithelial cells to identify bitter taste modulators.
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