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[미국특허] Osteoprotegerin 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-005/00
출원번호 US-0974022 (1997-11-18)
발명자 / 주소
  • Boyle William J.
  • Lacey David L.
  • Calzone Frank J.
  • Chang Ming-Shi
출원인 / 주소
  • Amgen Inc.
대리인 / 주소
    Winter
인용정보 피인용 횟수 : 51  인용 특허 : 2

초록

The present invention discloses a novel secreted polypeptide, termed Osteoprotegerin, which is a member of the tumor necrosis factor receptor superfamily and is involved in the regulation of bone metabolism. Also disclosed are nucleic acids encoding Osteoprotegerin, polypeptides, recombinant vectors

대표청구항

[ What is claimed is:] [1.] A transgenic non-human mammal having integrated into its genome a nucleic acid sequence encoding osteoprotegerin operatively linked to regulatory elements, wherein expression of said coding sequence increases the level of osteoprotegerin and the bone density of said mamma

이 특허에 인용된 특허 (2) 인용/피인용 타임라인 분석

  1. Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
  2. Levy Guy (Tustin CA), Optical fiber for use with dental laser.

이 특허를 인용한 특허 (51) 인용/피인용 타임라인 분석

  1. Yamaguchi,Kyoji; Yasuda,Hisataka; Nakagawa,Nobuaki; Shima,Nobuyuki; Kinosaki,Masahiko; Tsuda,Eisuke; Goto,Masaaki; Yano,Kazuki; Tomoyasu,Akihiro; Kobayashi,Fumie; Washida,Naohiro; Takahashi,Ken; Morinaga,Tomonori; Higashio,Kanji, Antibodies to OCIF-binding molecules.
  2. Boyle,William J.; Martin,Francis H.; Corvalan,Jose R.; Davis,C. Geoffrey, Antibodies to OPGL.
  3. Greene,John M.; Fleischmann,Robert D.; Ni,Jian, Antibodies to human tumor necrosis factor receptor-like genes.
  4. Gorman, Daniel M.; Mattson, Jeanine D., Antibodies to mammalian T cell surface antigen.
  5. Boyle, William J., Antibodies to osteoprotegerin binding proteins.
  6. Mochizuki, Shinichi; Fujise, Nobuaki; Masuyama, Chiharu; Tsuda, Eisuke; Higashio, Kanji, Bone-pathobolism treating agent.
  7. Anderson, Dirk M, Cells and methods for producing blocking antibodies to human RANKL.
  8. Alfred A. Reszka ; Edward S. Scolnick, Compositions and methods for inhibiting bone resorption.
  9. Reszka, Alfred A.; Scolnick, Edward S., Compositions and methods for inhibiting bone resorption.
  10. Boyle, William J.; Medlock, Eugene; Sullivan, John J.; Elliott, Robin L.; Martin, Frank; Huang, Haichun, Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors.
  11. Boyle, William J.; Medlock, Eugene; Sullivan, John K.; Elliott, Robin L.; Martin, Frank; Huang, Haichun, Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors.
  12. Boyle, William J.; Medlock, Eugene; Sullivan, John K.; Elliott, Robin L.; Martin, Frank; Huang, Haichun, Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors.
  13. Anderson,Dirk M., Kits containing rank polypeptides.
  14. Anderson, Dirk M, Kits for detecting rank.
  15. Gorman,Daniel E.; Mattson,Jeanine D., Mammalian cell surface antigens; related reagents.
  16. Nycz, Jeffrey H.; Serbousek, Jon C., Method and kit for repairing a defect in bone.
  17. Yano, Kazuki; Kobayashi, Fumie; Goto, Masaaki; Washida, Naohiro; Tsuda, Eisuke; Higashio, Kanji; Yamada, Yoshiji, Method for diagnosing bone dysbolism.
  18. Maraskovsky, Eugene, Method for enhancing the functional capacity of dendritic cells.
  19. Yano,Kazuki; Kobayashi,Fumie; Goto,Masaaki; Washida,Naohiro; Tsuda,Eisuke; Higashio,Kaoji; Yamada,Yoshiji, Method of diagnosing metabolic bone diseases.
  20. DeLuca,Hector F.; Pike,John W.; Shevde,Nirupama; Plum,Lori A.; Clagette Dame,Margaret, Method of extending the dose range of vitamin D compounds.
  21. Anderson, Dirk M.; Galibert, Laurent J., Method of inhibiting osteoclast activity.
  22. Anderson, Dirk M; Galibert, Laurent J, Method of inhibiting osteoclast activity.
  23. Malyankar, Uriel M.; Scatena, Marta; Giachelli, Cecilia M., Methods and devices for promoting endothelial morphogenesis.
  24. Malyankar,Uriel M.; Scatena,Marta; Giachelli,Cecilia M., Methods and devices for promoting endothelial morphogenesis.
  25. Yamaguchi,Kyoji; Yasuda,Hisataka; Nakagawa,Nobuaki; Shima,Nobuyuki; Kinosaki,Masahiko; Tsuda,Eisuke; Goto,Masaaki; Yano,Kazuki; Tomoyasu,Akihiro; Kobayashi,Fumie; Washida,Naohiro; Takahashi,Ken; Mori, Methods for identifying a substance which specifically binds to an osteoclastogenesis inhibitory factor-binding molecule and modulates the biological activity thereof.
  26. Huang, Chung-Jr; Yang, Xiaoming, Methods for increasing mannose content of recombinant proteins.
  27. Huang, Chung-Jr; Yang, Xiaoming, Methods for increasing mannose content of recombinant proteins.
  28. Wu, Jian; Davern, Sean; Petrovan, Simina Crina; Brandenstein, Michael Charles; Lindahl, Katherine Rose; Lillie, Shawn Erik, Methods for increasing mannose content of recombinant proteins.
  29. Anderson, Dirk M, Methods for interfering with rank signaling.
  30. Boyle, William J.; Martin, Francis H.; Corvalan, Jose R.; Davis, C. Geoffrey, Methods for treating bone loss with antibodies to OPGL.
  31. Goto,Masaaki; Tsuda,Eisuke; Mochizuki,Shin'ichi; Yano,Kazuki; Kobayashi,Fumie; Shima,Nobuyuki; Yasuda,Hisataka; Nakagawa,Nobuaki; Morinaga,Tomonori; Ueda,Masatsugu; Higashio,Kanji, Methods for using the osteoclastogenesis inhibitory factor (OCIF) protein.
  32. Yamaguchi, Kyoji; Yasuda, Hisataka; Nakagawa, Nobuaki; Shima, Nobuyuki; Kinosaki, Masahiko; Tsuda, Eisuke; Goto, Masaaki; Yano, Kazuki; Tomoyasu, Akihiro; Kobayashi, Fumie; Washida, Naohiro; Takahashi, Ken; Morinaga, Tomonori; Higashio, Kanji, Methods of reducing bone absorption comprising administering an antibody that binds OBM.
  33. Anderson,Dirk M., Monoclonal blocking antibody to human RANKL.
  34. Goto,Masaaki; Tsuda,Eisuke; Mochizuki,Shin'ichi; Yano,Kazuki; Kobayashi,Fumie; Shima,Nobuyuki; Yasuda,Hisataka; Nakagawa,Nobuaki; Morinaga,Tomonori; Ueda,Masatsugu; Higashio,Kanji, Nucleic acid molecules encoding osteoclastogenesis inhibitory factor proteins.
  35. Vidal, Karine; Van Den Broek, Peter; Offord Cavin, Elizabeth; Donnet Hughes, Anne, Osteoprotegerin in milk.
  36. Vidal, Karine; Van Den Broek, Peter; Offord Cavin, Elizabeth; Donnet-Hughes, Anne, Osteoprotegerin in milk.
  37. Roberts, Anthony; Kopsidas, George; Coia, Gregory; Sleigh, Merilyn; Batori, Vincent, Osteoprotegerin variant proteins.
  38. Roberts, Anthony; Kopsidas, George; Coia, Gregory; Sleigh, Merilyn; Batori, Vincent, Osteoprotegerin variant proteins.
  39. Gupta, Shivani; Kang, Sohye, Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins.
  40. Gupta, Shivani; Kang, Sohye, Overexpression of N-glycosylation pathway regulators to modulate glycosylation of recombinant proteins.
  41. Boyle, William J.; Martin, Francis H.; Corvalan, Jose R.; Davis, C. Geoffrey, Polynucleotides encoding heavy and light chains of antibodies to OPGL.
  42. Legembre, Patrick; Vacher, Pierre; Sanseau, Doriane; Penna, Aubin; Flynn, Robin, Polypeptides and uses thereof for reducing CD95-mediated cell motility.
  43. Leiske, Daniel R.; Trentalange, Michael T., Process for manipulating the level of glycan content of a glycoprotein.
  44. Goto, Masaaki; Tsuda, Eisuke; Mochizuki, Shin'ichi; Yano, Kazuki; Kobayashi, Fumie; Shima, Nobuyuki; Yasuda, Hisataka; Nakagawa, Nobuaki; Morinaga, Tomonori; Ueda, Masatsugu; Higashio, Kanji, Proteins and methods for producing the proteins.
  45. Anderson, Dirk M, RANK ligand polypeptides.
  46. Anderson, Dirk M.; Galibert, Laurent; Maraskovsky, Eugene; Dougall, William C., Receptor activator of NF-.kappa.B.
  47. Dirk M. Anderson ; Laurent Galibert ; Eugene Maraskovsky AU; William C. Dougall, Receptor activator of NF-.kappa.B.
  48. Dougall, William C.; Anderson, Dirk M.; Galibert, Laurent; Maraskovsky, Eugene, Receptor activator of NF-.kappa.B.
  49. Anderson, Dirk M; Galibert, Laurent; Maraskovsky, Eugene, Receptor activator of NF-kappaB.
  50. Dougall, William C., Screening assays for agonists and antagonists of receptor activator of NF-κB.
  51. Dougall, William C., Screening assays for agonists or antagonists or receptor activator of NF-κB.

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