초록 ▼

This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a biologically active agent to provide a release of the active agent at a constant rate over a prolonged per

This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a biologically active agent to provide a release of the active agent at a constant rate over a prolonged period of time. The pore forming agent is used in the formulation of the invention in the amount effective to regulate the release of a biologically active compound at a desired rate. Preferably, the effective amount of the pore forming agent provides long term delivery of the active agent. The invention also provides an improved implant for the sustained administration of a biologically active compound suitable for subcutaneous implantation. The invention also relates to methods for making and using the formulation and the implant of the invention.

대표청구항 ▼

[ What is claimed is:] [21.] A long term sustained-release implant comprising:(i) an effective amount of a biologically active agent; and(ii) a film coat comprising a mixture of a water insoluble polymer and a water soluble pore forming agent, said pore forming agent being in an amount effective to

[ What is claimed is:] [21.] A long term sustained-release implant comprising:(i) an effective amount of a biologically active agent; and(ii) a film coat comprising a mixture of a water insoluble polymer and a water soluble pore forming agent, said pore forming agent being in an amount effective to regulate the release of said biologically active compound, wherein the duration of sustained release of the implant in a mammal is greater than 150 days.