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Synthesis of oligonucleotide arrays using photocleavable protecting groups 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/00
출원번호 US-0630148 (1996-04-10)
발명자 / 주소
  • McGall Glenn H.
  • Nam Ngo Quoc
출원인 / 주소
  • Affymetrix, Inc.
대리인 / 주소
    Morrison & Foerster, LLP
인용정보 피인용 횟수 : 150  인용 특허 : 11

초록

Also provided is a method of forming, from component molecules, a plurality of compounds on a support, each compound occupying a separate predefined region of the support, using the protected compounds described above.

대표청구항

[ What is claimed is:] [1.] A method of attaching a molecule with a reactive site to a support comprising the steps of:(a) providing a support with a reactive site;(b) binding a molecule to the reactive site, said first molecule comprising a masked reactive site attached to a photolabile protecting

이 특허에 인용된 특허 (11)

  1. Southern Edwin (Oxford GB2), Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays.
  2. Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Array of oligonucleotides on a solid substrate.
  3. Winkler James L. (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Buchko Christopher J. (Ann Arbor MI) Ross Debra A. (Fremont CA) Aldwin Lois (San Mateo CA) Modlin Douglas N. (Palo Alto CA), Combinatorial strategies for polymer synthesis.
  4. Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof.
  5. Urdea Michael S. (Alamo CA) Horn Thomas (Berkeley CA), Oligonucleotides having selectably cleavable and/or abasic sites.
  6. Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA) Winkler James L. (Palo Alto CA) Holmes Christopher P. (Sunnyvale CA) Solas Dennis W. (San Francisco CA), Photolabile nucleoside and peptide protecting groups.
  7. Ruoss Erich (Bndtenstr. 25 5417 Untersiggenthal CHX) Schett Georg (Stockenerstr. 64 8405 Winterthur CHX), Reactor switch.
  8. Dower William J. (Menlo Park CA) Barrett Ronald W. (Sunnyvale CA) Gallop Mark A. (Palo Alto CA) Needels Michael C. (Oakland CA), Synthesizing and screening molecular diversity.
  9. Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA), Very large scale immobilized polymer synthesis.
  10. Winkler James L. (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Buchko Christopher J. (Palo Alto CA) Ross Debra A. (Fremont CA) Aldwin Lois (San Mateo CA), Very large scale immobilized polymer synthesis using mechanically directed flow paths.
  11. Cozzette Stephen N. (Nepean CAX) Davis Graham (Plainsboro NJ) Itak Jeanne A. (North Brunswick NJ) Lauks Imants R. (Yardley PA) Mier Randall M. (Morrisville PA) Piznik Sylvia (Jackson NJ) Smit Nicolaa, Wholly microfabricated biosensors and process for the manufacture and use thereof.

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