초록 ▼

The present invention is directed to a device useful for measuring functional characteristics of an organ being perfused at near normal metabolism using an ex vivo warm preservation process/system. The device comprises means for diverting from the flow lines of the warm preservation system a small s

The present invention is directed to a device useful for measuring functional characteristics of an organ being perfused at near normal metabolism using an ex vivo warm preservation process/system. The device comprises means for diverting from the flow lines of the warm preservation system a small sample of perfusate which has already circulated through the organ, and means for collecting the perfusate that measurements can be performed. The functional characteristics include parameters reflecting organ metabolism measured from perfusate which has circulated through the organ, from organ product produced and collected from the organ, or from both the circulated perfusate and the collected organ product during the warm preservation process/system. The measured parameters may then be compared to reference intervals as a method of prospectively assessing functional capabilities of the organ posttransplantation.

대표청구항 ▼

[ What is claimed is:] [1.] A device which is operatively linked to an ex vivo warm preservation system having flow lines and a non-blood perfusate circulating through said flow lines wherein said system performs a process of perfusing and preserving an organ ex vivo at near normal metabolism, where

[ What is claimed is:] [1.] A device which is operatively linked to an ex vivo warm preservation system having flow lines and a non-blood perfusate circulating through said flow lines wherein said system performs a process of perfusing and preserving an organ ex vivo at near normal metabolism, wherein said device comprises:(a) means for diverting from the flow lines a sample of perfusate which has already circulated through the organ, while maintaining the overall integrity of the perfusion process; and(b) means for collecting the perfusate so that measurements of the perfusate can be subsequently performed.