초록 ▼

A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium phosphate is characterized in that, when placed in an intramuscular or subcutaneous site, resorption of a

A composite material is provided including a strongly bioresorbable, poorly crystalline apatitic calcium phosphate composite and a supplementary material. The poorly crystalline apatitic calcium phosphate is characterized in that, when placed in an intramuscular or subcutaneous site, resorption of at least 1 g of the material is complete within one year. The supplementary material is in intimate contact with the hydroxyapatite material in an amount effective to impart a selected characteristic to the composite. The supplemental material may be biocompatible, bioresorbable or non-resorbable.

대표청구항 ▼

[ What is claimed is:] [1.] A composite material, comprising:(a) a strongly resorbable, poorly crystalline apatitic (PCA) calcium phosphate cement having an x-ray diffraction pattern similar to naturally occurring bone made by the process comprising:providing a paste comprised of amorphous calcium p

[ What is claimed is:] [1.] A composite material, comprising:(a) a strongly resorbable, poorly crystalline apatitic (PCA) calcium phosphate cement having an x-ray diffraction pattern similar to naturally occurring bone made by the process comprising:providing a paste comprised of amorphous calcium phosphate and water, whereby the paste hardens and converts to the poorly crystalline apatitic calcium phosphate,the poorly crystalline apatitic calcium phosphate characterized in that, at least about 80% is resorbed within one year when 1 g of the PCA calcium phosphate is placed in a rat intramuscular site; and(b) a biocompatible supplemental material, said material in intimate contact with the poorly crystalline material and present in an amount effective to impart a selected characteristic to the composite.