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Guided development and support of hydrogel-cell compositions 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-002/02
  • A61F-002/28
출원번호 US-0066038 (1998-04-24)
발명자 / 주소
  • Vacanti Charles A.
  • Vacanti Joseph P.
출원인 / 주소
  • The Children's Medical Center Corporation
대리인 / 주소
    Fish & Richardson P.C.
인용정보 피인용 횟수 : 110  인용 특허 : 45

초록 ▼

The invention features a method for generating new tissue, the method including: obtaining a liquid hydrogel-cell composition including a hydrogel and tissue precursor cells; delivering the liquid hydrogel-cell composition into a permeable, biocompatible support structure; and allowing the liquid hy

대표청구항 ▼

[ What is claimed is:] [1.] A method for generating new tissue, the method comprising:obtaining a liquid hydrogel-cell composition comprising a hydrogel and tissue precursor cells;delivering the liquid hydrogel-cell composition into a permeable, biocompatible support structure; andallowing the liqui

이 특허에 인용된 특허 (45)

  1. Viegas Tacey X. (Ann Arbor MI) Reeve Lorraine E. (Ann Arbor MI) Henry Raymond L. (Grosse Pointe Woods MI), Ablatable mask of polyoxyalkylene polymer and ionic polysaccharide gel for laser reprofiling of the cornea.
    상세보기
  2. Fox Adrian S. (New Windsor NY) Czap Christine A. (Montgomery NY) Wiser Robin R. (Chester NY), Adhesive hydrogels having extended use lives and process for the preparation of same.
    상세보기
  3. Mikos Antonios G. (Houston TX) Sarakinos Georgios (Boston MA) Vacanti Joseph P. (Winchester MA) Langer Robert S. (Newton MA) Cima Linda G. (Lexington MA), Biocompatible polymer membranes and methods of preparation of three dimensional membrane structures.
    상세보기
  4. Vacanti Joseph P. ; Vacanti Charles A. ; Langer Robert S., Biodegradable synthetic polymeric fibrous matrix containing chondrocyte for in vivo production of a cartilaginous struct.
    상세보기
  5. Viegas Tacey X. (Ann Arbor MI) Reeve Lorraine E. (Dexter MI) Levinson Robert S. (Chesterfield MO), Body cavity drug delivery with thermoreversible gels containing polyoxyalkylene copolymers.
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  6. Vacanti Joseph P. ; Atala Anthony ; Mooney David J. ; Langer Robert S., Breast tissue engineering.
    상세보기
  7. Henry Raymond L. (Grosse Pointe Woods MI), Composition and method for post-surgical adhesion reduction with thermo-irreversible gels of polyoxyalkylene polymers an.
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  8. Schlameus Herman W. (San Antonio TX) Fox William C. (San Antonio TX) Mangold Donald J. (San Antonio TX) Triplett Robert G. (Dallas TX) Holt George R. (San Antonio TX) Aufdemorte Thomas B. (Lakeway TX, Composition and method of promoting hard tissue healing.
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  9. Scheicher Hans (Rondell Neuwittelsbach 4 D-8000 Munich DEX), Corrective agent for the covering and/or filling of bone defects, method for the preparation of same and method of using.
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  10. Viegas Tacey X. (Ann Arbor MI) Reeve Lorraine E. (Dexter MI) Levinson Robert S. (Chesterfield MO), Drug delivery by injection with thermoreversible gels containing polyoxyalkylene copolymers.
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  11. Vacanti Joseph P. ; Breuer Christopher K. ; Chaignaud Beverly E. ; Shin'oka Toshiraru, Engineering of strong, pliable tissues.
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  12. Hubbell Jeffrey A. (Concord MA) Pathak Chandrashekhar P. (Austin TX) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hossainy Syed F. A. (Austin TX), Gels for encapsulation of biological materials.
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  13. Vacanti Joseph P. (Winchester MA) Freeman Michael R. (Boston MA), Genitourinary cell-matrix structure for implantation into a human and a method of making.
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  14. Cauley Keith ; Kukekov Valery, Human oligodendroglial progenitor cell line.
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  15. Bao Qi-Bin (Livingston NJ) Higham Paul A. (Ringwood NJ), Hydrogel bead intervertebral disc nucleus.
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  16. Vacanti Joseph P. ; Langer Robert S. ; Johnson Lynt, Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue.
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  17. Weiss Samuel,CAX ; Reynolds Brent,CAX ; Hammang Joseph P. ; Baetge E. Edward, In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny.
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  19. Atala Anthony (Newton MA), Injectable bladder muscle cells-polymer suspension for treatment of vesicoureteral reflux and incontinence.
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  22. Slepian Marvin (Tucson AZ) Massia Stephen P. (Tucson AZ), Local polymeric gel therapy.
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  23. Rosenberg Robert D. (Jamestown RI) Simons Michael (Chestnut Hill MA) Edelman Elazer (Brookline MA) Langer Robert S. (Newton MA) DeKeyser Jean-Luc (Brussels BEX), Localized oligonucleotide therapy.
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  24. Anderson David J. (Altadena CA) Stemple Derek L. (Pasadena CA), Mammalian neural crest stem cells.
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  25. Viegas Tacey X. (Canton MI) Reeve Lorraine E. (Dexter MI) Henry Raymond L. (Grosse Pointe Woods MI), Medical uses of in situ formed gels.
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  26. Schinstine Malcolm ; Shoichet Molly S.,CAX ; Gentile Frank T. ; Hammang Joseph P. ; Holland Laura M. ; Cain Brian M. ; Doherty Edward J. ; Winn Shelley R. ; Aebischer Patrick,CHX, Method for controlling proliferation and differentiation of cells encapsulated within bioartificial organs.
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  27. Gage Fred H. ; Schinstine Malcolm ; Ray Jasodhara ; Friedmann Theodore ; Kawaja Michael D.,CAX ; Rosenberg Michael B. ; Wolff Jon A., Method of grafting genetically modified cells to treat defects, disease or damage of the central nervous system.
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  28. Gage Fred H. (La Jolla CA) Rosenberg Michael B. (San Diego CA) Friedmann Theodore (La Jolla CA), Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system.
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  29. Vacanti Joseph P. (Winchester MA) Vacanti Charles A. (Lexington MA) Langer Robert S. (Newton MA), Neomorphogenesis of cartilage in vivo from cell culture.
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  30. Bellamkonda Ravi ; Ranieri John P.,CHX ; Aebischer Patrick,CHX, Nerve guidance channel containing bioartificial three-dimensional hydrogel extracellular matrix derivatized with cell a.
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  31. Viegas Tacey X. (Ann Arbor MI) Reeve Lorraine E. (Ann Arbor MI) Levinson Robert S. (Saline MI), Ophthalmic drug delivery with thermoreversible polyoxyalkylene gels adjustable for pH.
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  32. Hubbell Jeffrey A. (Austin TX) Pathak Chandrashekhar P. (Waltham MA) Sawhney Amarpreet S. (Newton MA) Desai Neil P. (Los Angeles CA) Hill Jennifer L. (Austin TX), Photopolymerizable biodegradable hydrogels as tissue contacting materials and controlled-release carriers.
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  33. Young Henry E. ; Lucas Paul A., Pluripotent mesenchymal stem cells and methods of use thereof.
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  34. Mikos Antonios G. (Houston TX) Langer Robert S. (Newton MA), Preparation of bonded fiber structures for cell implantation.
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  35. Mikos Antonios G. (Houston TX) Langer Robert S. (Newton MA), Preparation of bonded fiber structures for cell implantation.
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  36. Vacanti Joseph P. ; Langer Robert S., Preparation of three-dimensional fibrous scaffold for attaching cells to produce vascularized tissue in vivo.
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  37. Grande Daniel A. (12 Laurel Ave. Glen Cove NY 11542), Technique for healing lesions in cartilage.
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  38. Naughton Gail K. (Groton VT) Naughton Brian A. (Groton VT), Three-dimensional blood-brain barrier cell and tissue culture system.
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  39. Naughton Gail K. (Groton VT) Naughton Brian A. (Groton VT), Three-dimensional cell and tissue culture system.
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  40. Vacanti Joseph P. ; Langer Robert S., Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo.
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  41. Vacanti Joseph P. ; Langer Robert S., Three-dimensional fibrous scaffold containing attached cells for producing vascularized tissue in vivo.
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  42. Griffith-Cima Linda ; Atala Anthony ; Vacanti Charles A. ; Paige Keith T., Tissue formation by injecting a cell-polymeric solution that gels in vivo.
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  43. Viegas Tacey X. (Canton MI) Reeve Lorraine E. (Dexter MI) Levinson Robert S. (Chesterfield MO), Topical drug delivery with polyoxyalkylene polymer thermoreversible gels adjustable for pH and osmolality.
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  44. Viegas Tacey X. (Ann Arbor MI) Reeve Lorraine E. (Ann Arbor MI) Henry Raymond L. (Grosse Pointe Woods MI), Topical drug delivery with thermo-irreversible gels.
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  45. Walthall Bennie J. (El Sobrante CA) McHugh Yvonne E. (Berkeley CA) Voss Houston F. (Pleasanton CA), Transplantable artificial tissue and process.
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