초록

and the method of the present invention increases the rate of solvent removal from microspheres in in-water drying, reduces the amount of solvent in microspheres in a short time.

대표청구항 ▼

[ What we claim is:] [1.] A sustained-release microsphere comprising a physiologically active substance and a biodegradable polymer, which is produced by a process which comprises:subjecting a w/o/w emulsion or o/w emulsion wherein said physiologically active substance is in an inner aqueous phase a

[ What we claim is:] [1.] A sustained-release microsphere comprising a physiologically active substance and a biodegradable polymer, which is produced by a process which comprises:subjecting a w/o/w emulsion or o/w emulsion wherein said physiologically active substance is in an inner aqueous phase and said biodegradable polymer is in an external oil phase to an in-water drying method under the following conditions:1) the amount of microspheres per m.sup.3 in an external aqueous phase is about 0.1 to about 500 kg,2) the square root of the area (unit: m.sup.2) of the liquid surface in contact with the gas phase is about 0.2 to about 4.5 per the cube root of the volume (unit: m.sup.3) of the external aqueous phase,3) the w/o/w emulsion or o/w emulsion is replaced at a replacement frequency of about 0.01 to about 10 times/minute,4) a gas is blown toward the w/o/w emulsion or o/w emulsion so that the gas transfer rate near the liquid surface is about 10 to 300 m/second, and5) the gas is replaced at a replacement frequency of not less than about 0.5 times/minute.