Supplemented and unsupplemented tissue sealants, methods of their production and use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-034/14
A61K-038/22
A61K-038/44
A61K-038/49
출원번호
US-0479034
(1995-06-07)
발명자
/ 주소
MacPhee Martin James
Drohan William Nash
Woolverton Christoper J.
출원인 / 주소
The American National Red Cross
대리인 / 주소
Sterne, Kessler, Goldstein & Fox P.L.L.C.
인용정보
피인용 횟수 :
229인용 특허 :
51
초록▼
This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compo
This invention provides a fibrin sealant dressing, wherein said fibrin sealant may be supplemented with at least one composition selected from, for example, one or more regulatory compounds, antibody, antimicrobial compositions, analgesics, anticoagulants, antiproliferatives, anti-inflammatory compounds, cytokines, cytotoxins, drugs, growth factors, interferons, hormones, lipids, demineralized bone or bone morphogenetic proteins, cartilage inducing factors, oligonucleotides polymers, polysaccharides, polypeptides, protease inhibitors, vasoconstrictors or vasodilators, vitamins, minerals, stabilizers and the like. Also disclosed are methods of preparing and/or using the unsupplemented or supplemented fibrin sealant dressing.
대표청구항▼
[ What is claimed is:] [1.] An expanding fibrin sealant foam for treating wounded tissue in a patient comprising(i) fibrinogen, or a derivative or metabolite thereof, in an amount which forms a fibrin matrix; and(ii) an agent which causes fibrinogen to foam during application of said fibrinogen to w
[ What is claimed is:] [1.] An expanding fibrin sealant foam for treating wounded tissue in a patient comprising(i) fibrinogen, or a derivative or metabolite thereof, in an amount which forms a fibrin matrix; and(ii) an agent which causes fibrinogen to foam during application of said fibrinogen to wounded tissue. such that said fibrinogen expands to fill the wound and form a fibrin matrix that covers and adheres to said wounded tissue.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (51)
Redl Heinz (Vienna ATX) Habison Georg (Vienna ATX), Apparatus for applying a tissue adhesive.
Redl Heinz (Vienna ATX) Schlag Gnther (Vienna ATX) Pridun Nestor (Vienna ATX), Biologic absorbable implant material for filling and closing soft tissue cavities and method of its preparation.
Errede Louis A. (North Oaks MN) Stoesz James D. (St. Paul MN) Winter ; deceased George D. (late of St. Paul MN by Jenny Upton ; personal representative), Composite wound dressing.
Wahlig Helmut (Darmstadt DEX) Dingeldein Elvira (Dreieich DEX) Kirchlechner Richard (Rott a. Inn DEX) Orth Dieter (Darmstadt DEX) Rogalski Werner (Alsbach DEX), Flavonoid phosphate salts of aminoglycoside antibiotics.
Ron Eyal (Lexington MA) Schaub Robert G. (Pelham NH) Turek Thomas J. (Boston MA), Formulations of blood clot-polymer matrix for delivery of osteogenic proteins.
Williams Stuart K. (Drexel Hill PA) Jarrell Bruce E. (Philadelphia PA), Method of treating a synthetic or naturally occuring surface with microvascular endothelial cells, and the treated surfa.
Luck Edward E. (Menlo Park CA) Brown Dennis M. (Menlo Park CA), Treatments employing drug-containing matrices for introduction into cellular lesion areas.
Antoniades Harry N. (Newton MA) Lynch Samuel E. (Jamaica Plain MA) Williams Ray C. (Arlington MA), Wound healing and bone regeneration using PDGF and IGF-I.
McCarthy, Simon; McGrath, Barbara; Winata, Ervelyn, Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan.
Richards, Mark; Burkinshaw, Brian D.; Pauza, Kevin; Rogan, James B.; Wheeler, John, Apparatus and method for injection of fibrin sealant in spinal applications.
Higgins, Joel C.; Leach, Michael D.; Woodell-May, Jennifer E.; Miller, Brandon, Apparatus and method for separating and concentrating fluids containing multiple components.
Higgins, Joel C.; Swift, Matthew; Gordon, Nathan; Hecker, Barry F., Apparatus and method for separating and concentrating fluids containing multiple components.
Higgins, Joel C.; Swift, Matthew; Gordon, Nathan; Hecker, Barry F., Apparatus and method for separating and concentrating fluids containing multiple components.
Landrigan, Matthew D.; Leach, Michael D.; Higgins, Joel C., Apparatus and method for separating and concentrating fluids containing multiple components.
Landrigan, Matthew D.; Leach, Michael D.; Higgins, Joel C., Apparatus and method for separating and concentrating fluids containing multiple components.
Leach, Michael D.; Higgins, Joel C.; Swift, Matthew; Gordon, Nathan, Apparatus and method for separating and concentrating fluids containing multiple components.
Leach, Michael D.; Higgins, Joel C.; Swift, Matthew; Gordon, Nathan, Apparatus and method for separating and concentrating fluids containing multiple components.
Leach, Michael D.; Woodell-May, Jennifer E.; Higgins, Joel C.; Miller, Brandon, Apparatus and method for separating and concentrating fluids containing multiple components.
Leach, Michael D.; Woodell-May, Jennifer E.; Higgins, Joel C.; Miller, Brandon, Apparatus and method for separating and concentrating fluids containing multiple components.
Cornwell, Kevin G.; Pins, George D.; Billiar, Kristen, Collagen and fibrin microthreads in a discrete thread model of in vitro ACL scaffold regeneration.
McAdams, Staci Ann; Block, William David; McCarthy, Simon John; Gregory, Kenton W.; Oien, Hal, Compositions, assemblies, and methods applied during or after a dental procedure to ameliorate fluid loss and/or promote healing, using a hydrophilic polymer sponge structure such as chitosan.
Eaton, Donald J.; Tice, Thomas R.; Downie, David B.; Arensdorf, Patrick A.; Brenneman, Rodney A.; Biggs, Danielle L., Device and methods for treating paranasal sinus conditions.
Eaton, Donald J.; Tice, Thomas R.; Downie, David B.; Arensdorf, Patrick A.; Brenneman, Rodney A.; Biggs, Danielle L., Device and methods for treating paranasal sinus conditions.
Eaton, Donald J.; Tice, Thomas R.; Downie, David B.; Arensdorf, Patrick A.; Brenneman, Rodney; Biggs, Danielle L., Device and methods for treating paranasal sinus conditions.
Eaton, Donald J.; Tice, Thomas R.; Downie, David B.; Arensdorf, Patrick A.; Brenneman, Rodney; Biggs, Danielle L., Device and methods for treating paranasal sinus conditions.
Eaton, Donald J.; Tice, Thomas R.; Downie, David B.; Arensdorf, Patrick A.; Brenneman, Rodney; Biggs, Danielle L., Device and methods for treating paranasal sinus conditions.
Arensdorf, Patrick A.; Biggs, Danielle L.; Brenneman, Rodney; Downie, David B.; Eaton, Donald J.; Tice, Thomas R., Devices and methods for delivering active agents to the osteomeatal complex.
Arensdorf, Patrick A.; Biggs, Danielle L.; Brenneman, Rodney; Downie, David B.; Eaton, Donald J.; Tice, Thomas R., Devices and methods for delivering active agents to the osteomeatal complex.
Ny, Tor; Li, Jinan; Guo, Yongzhi; Lindh, Tomas, Drug target for preventing and treating periodontal disease, improving healing of periodontal wounds and promoting oral health.
Burkinshaw, Brian D.; Whitlock, Steven I.; Rogan, James B.; Devries, Gerald L., Enhanced biological autologous tissue adhesive composition and methods of preparation and use.
Hubbell,Jeffrey A.; Schense,Jason C.; Sakiyama,Shelly E., Enzyme-mediated modification of fibrin for tissue engineering: fibrin formulations with peptides.
Bianchi, Marco E.; Bonaldi, Tiziana; Scaffidi, Paola; Mueller, Susanne; Degryse, Bernard, HMGB1 protein inhibitorsand/or antagonists for the treatment of vascular diseases.
McCarthy, Simon J., Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan.
McCarthy, Simon J., Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as chitosan.
McCarthy, Simon J., Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as chitosan.
Montes, Joseph G.; Rangan, Krishnaswamy Kasthuri; Radhakrishnan, Ramachandran; Sudarshan, Tirumalai Srinivas, In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide.
Montes, Joseph G.; Rangan, Krishnaswamy Kasthuri; Radhakrishnan, Ramachandran; Sudarshan, Tirumalai Srinivas, In situ formation of an artificial blockage to control bleeding by polymer expansion with hydrogen peroxide and platinum catalyst.
Pauza, Kevin; Burkinshaw, Brian D.; Whitlock, Steven I.; Richards, Mark I.; Rogan, James B., Injection of fibrin sealant including an anesthetic in spinal applications.
Pauza, Kevin; Burkinshaw, Brian D.; Whitlock, Steven I.; Richards, Mark I.; Rogan, James B., Injection of fibrin sealant including an anesthetic in spinal applications.
Pauza, Kevin; Burkinshaw, Brian D.; Whitlock, Steven I.; Richards, Mark I.; Rogan, James B., Injection of fibrin sealant including an anesthetic in spinal applications.
Burkinshaw, Brian D.; Whitlock, Steven I.; Pauza, Kevin; Richards, Mark I.; Rogan, James B., Injection of fibrin sealant using reconstituted components in spinal applications.
Burkinshaw, Brian D.; Whitlock, Steven I.; Pauza, Kevin; Richards, Mark I.; Rogan, James B., Injection of fibrin sealant using reconstituted components in spinal applications.
Burgess, James E.; Campbell, Phil G.; Weiss, Lee E.; Smith, Jason, Method and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom.
Leach, Michael D.; Higgins, Joel C.; Swift, Matthew; Gordon, Nathan, Method and apparatus for separating and concentrating a component from a multi-component material including macroparticles.
Dolecek, Victor D.; Baugh, Robert F.; Rivera, John G.; McKay, William F.; Marx, Jeffery C., Method for the production of a blood component composition.
Jamiolkowski, Dennis D.; Brown, Kelly R.; Chun, Iksoo; Melican, Mora Carolynne, Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof.
Campbell, Phil G.; Burgess, James E.; Weiss, Lee E.; Smith, Jason, Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom.
Campbell, Phil G.; Burgess, James E.; Weiss, Lee E.; Smith, Jason, Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom.
Campbell, Phil G.; Burgess, James E.; Weiss, Lee E.; Smith, Jason, Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom.
Campbell, Phil G.; Burgess, James E.; Weiss, Lee E.; Smith, Jason, Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom.
Campbell, Phil G.; Burgess, James E.; Weiss, Lee E.; Smith, Jason, Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom.
Campbell, Phil G.; Burgess, James E.; Weiss, Lee E.; Smith, Jason, Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom.
Campbell, Phil G.; Burgess, James E.; Weiss, Lee E.; Smith, Jason, Methods and apparatus for manufacturing plasma based plastics and bioplastics produced therefrom.
Abbate, Anthony J.; Huang, Bin; Zaler, Gail M.; Gale, David C.; Kaufman, Richard E.; Rajasekhar, Vijaykumar, Methods and devices for crimping self-expanding devices.
Abbate, Anthony J.; Huang, Bin; Zaler, Gail M.; Gale, David C.; Kaufman, Richard E.; Rajasekhar, Vijaykumar, Methods and devices for crimping self-expanding devices.
Binder, Jeffrey R.; Higgins, Joel C.; Leach, Michael D.; O'Shaughnessey, Krista; Woodell-May, Jennifer E., Methods and non-immunogenic compositions for treating inflammatory disorders.
Leach, Michael D.; Woodell-May, Jennifer E.; Higgins, Joel C.; O'Shaughnessey, Krista, Methods for making cytokine compositions from tissues using non-centrifugal methods.
Leach, Michael D.; Woodell-May, Jennifer E.; Higgins, Joel C.; O'Shaughnessey, Krista, Methods for making cytokine compositions from tissues using non-centrifugal methods.
Miller, Mark E.; Cortese, Stephanie M.; Schwartz, Herbert E.; Oppelt, William G., Polyacid/polyalkylene oxide foams and gels and methods for their delivery.
Amery, Michael J.; Sibbons, Paul; Burnett, Stuart; Rickets, Sally-Anne; Edwardson, Peter A. D.; Hughes, Jonathan; Hollingsbee, Derek A.; Cederholm-Williams, Stewart A.; Trumbull, Horace R.; Griffin, , Prevention of post surgical adhesions using a fibrin monomer sealant.
Bowman, Steven M.; Bruker, Izi; Rezania, Alireza; Melican, Mora Carolynne; Binette, Francois; Hwang, Julia, Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration.
McCauley, Dilara; Diener, John L.; Wilson, Charles; McCauley, Thomas Greene, Stabilized aptamers to platelet derived growth factor and their use as oncology therapeutics.
Gregory, Kenton W.; Bente, IV, Paul F.; Bryan, Heather Margaret; Lin, Jeffrey Yihyuan; Nuguid, Aileen; Pederson, Daniel Allen, Systems and methods for hemorrhage control and or tissue repair.
Landrigan, Matthew D.; O'Shaughnessey, Krista; Woodell-May, Jennifer E.; Suter, David L., Treatment of peripheral vascular disease using protein solutions.
McCarthy, Simon J.; Gregory, Kenton W.; Wiesmann, William P.; Campbell, Todd D., Wound dressing and method for controlling severe, life-threatening bleeding.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.