초록

characterized:

대표청구항 ▼

[ We claim:] [1.] A pharmaceutical composition for oral administration, providing enhanced bioavailability when ingested and contacted with biological fluids of the body, comprising a lipophilic phase, a surfactant, a cosurfactant and a pharmaceutical active ingredient;the lipophilic phase being pre

[ We claim:] [1.] A pharmaceutical composition for oral administration, providing enhanced bioavailability when ingested and contacted with biological fluids of the body, comprising a lipophilic phase, a surfactant, a cosurfactant and a pharmaceutical active ingredient;the lipophilic phase being present in an amount of from 1 to 75% by weight based on the total weight of the composition; the surfactant, cosurfactant and pharmaceutical active ingredient comprising the remainder and the ratio of surfactant to cosurfactant being between 0.5 and 6;the lipophilic phase having a hydrophilic-lipophilic balance (HLB) of less than 16 and being obtained by an alcoholysis reaction of polyethylene glycol and a starting oil, the oil consisting of a mixture of mono, di and triglycerides of fatty acids selected from the group consisting of caprylic, capric, lauric, myristic, palmitic, stearic, oleic, linoleic and linolenic acids, at least 60% by weight in respect of total fatty acids containing 12 and more carbon atoms;the surfactant is a product, having an HLB of less than 16, obtained by an alcoholysis reaction of polyethylene glycol and a fraction of oil consisting of a mixture of triglycerides of fatty acids selected from the group consisting of caprylic and capric acids; andthe cosurfactant consisting of a polyvalent alcohol ester selected from the group consisting of lauric esters of propylene glycol, oleic esters of polyglycerol and ethyl diglycol,and where each of said lipophilic phase, surfactant, cosurfactant and pharmaceutical active ingredient are miscible and substantially anhydrous; said composition providing enhanced bioavailability when ingested and contacted with the biological fluids of the body.