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Analying polynucleotide sequences 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
출원번호 US-0925676 (1997-09-09)
우선권정보 GB-0010400 (1988-05-03)
발명자 / 주소
  • Southern Edwin,GBX
출원인 / 주소
  • Oxford Gene Technology Limited, GBX
대리인 / 주소
    Wenderoth, Lind & Ponack, L.L.P.
인용정보 피인용 횟수 : 245  인용 특허 : 19

초록 ▼

This invention provides an apparatus and method for analyzing a polynucleotide sequence; either an unknown sequence or a known sequence. A support, e.g. a glass plate, carries an array of the whole or a chosen part of a complete set of oligonucleotides which are capable of taking part in hybridizati

대표청구항 ▼

[ I claim:] [1.] A method of making an array of oligonucleotides, which comprises:attaching a plurality of oligonucleotides to an impermeable surface of a support, the oligonucleotides having different predetermined sequences and being attached at different known locations on the surface of the supp

이 특허에 인용된 특허 (19)

  1. Southern Edwin (Oxford GB2), Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays.
    상세보기
  2. Hamill Brendan J. (11 ; Napier Square Livingston EH54 5DG GB6), Apparatus for the chemical synthesis of oligonucleotides.
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  3. Fodor Stephen P. A. (Palo Alto CA) Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Stryer Lubert (Stanford CA), Array of oligonucleotides on a solid substrate.
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  4. Fodor Stephen P.A. ; Stryer Lubert ; Read J. Leighton ; Pirrung Michael C., Arrays of materials attached to a substrate.
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  5. Huang Henry V. (232 S. Catalina Pasadena CA 91106), Automated method for quantitative analysis of biological fluids.
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  6. Winkler James L. (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Buchko Christopher J. (Ann Arbor MI) Ross Debra A. (Fremont CA) Aldwin Lois (San Mateo CA) Modlin Douglas N. (Palo Alto CA), Combinatorial strategies for polymer synthesis.
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  7. Ranki Tuula M. (Espoo FIX) Soderlund Hans E. (Espoo FIX), Detection of microbial nucleic acids by a one-step sandwich hybridization test.
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  8. Holmes Christopher P. (Sunnyvale CA), Immobilized molecular synthesis of systematically substituted compounds.
    상세보기
  9. Singer Robert H. (Shrewsbury MA) Lawrence Jeanne B. (Mapleville RI), In-situ hybridization to detect nucleic acid sequences in morphologically intact cells.
    상세보기
  10. Stavrianopoulos Jannis G. (New York NY) Kirtikar Dollie (Elmhurst NY) Johnston Kenneth H. (New York NY) Thalenfeld Barbara E. (New York NY), Method and structures employing chemically-labelled polynucleotide probes.
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  11. Wilson Lois B. (Richmond County GA) Wilson John T. (Richmond County GA) Geever Robert F. (Aiken County SC), Method for the direct analysis of sickle cell anemia.
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  12. Mundy Christopher R. (Buckinghamshire GB2), Method of detecting mutations in DNA and RNA.
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  13. Fodor Stephen P. A. ; Solas Dennis W. ; Dower William J., Method of identifying nucleotide differences.
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  14. Johnson Leighton C. (Edwardsburg MI), Method of making printed reagent test devices.
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  15. Drmanac Radoje T. (Zvecanska 46 Beograd 11000) Crkvenjakov Radomir B. (Bulevar JNA 118 Beograd YUX 11000), Method of sequencing of genomes by hybridization of oligonucleotide probes.
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  16. Brown Patrick O. ; Shalon Tidhar Dari, Methods for fabricating microarrays of biological samples.
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  17. Hafeman Dean G. (San Bruno CA) McConnell Harden M. (Stanford CA), Multiple chemically modulated capacitance determination.
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  18. Macevicz Stephen C. (21890 Rucker Dr. Cupertino CA 95014), Nucleic acid sequence determination by multiple mixed oligonucleotide probes.
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  19. Humphries Gillian M. K. (Los Altos CA) Parce John W. (Winston-Salem NC) McConnell Harden M. (Stanford CA), Photoresponsive redox detection and discrimination.
    상세보기

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