$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

.alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors

국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/505
  • C07D-023/902
  • C07D-021/178
  • C07D-027/730
출원번호 US-0204827 (1994-03-02)
발명자 / 주소
  • Vazquez Michael L.
  • Mueller Richard A.
  • Talley John J.
  • Getman Daniel P
  • DeCrescenzo Gary A.
  • Freskos John N.
  • Heintz Robert M.
  • Bertenshaw Deborah E.
출원인 / 주소
  • G. D. Searle & Co.
대리인 / 주소
    Banner & Witcoff, Ltd.
인용정보 피인용 횟수 : 43  인용 특허 : 1

초록

.alpha.- and .beta.-amino acid hydroxyethylamino sulfonamide compounds are effective as retroviral protease inhibitors, and in particular as inhibitors of HIV protease.

대표청구항

[ What is claimed is:] [1.] A compound represented by the formula: [ STR 495 ] or a pharmaceutically acceptable salt thereof wherein R.sup.2 is an alkyl, aryl, cycloalkyl, cycloalkylalkyl or aralkyl radical, which radical is optionally substituted with a radical selected from the group consisting of

이 특허에 인용된 특허 (1)

  1. Tung Roger D. (Arlington MA) Murcko Mark A. (Holliston MA) Bhisetti Govinda R. (Lexington MA), Sulfonamide inhibitors of aspartyl protease.

이 특허를 인용한 특허 (43)

  1. Vazquez,Michael J.; Mueller,Richard A.; Talley,John J.; Getman,Daniel P.; DeCrescenzo,Gary A.; Freskos,John N.; Heintz,Robert M.; Bertenshaw,Deborah E., α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  2. Vazquez,Michael L.; Mueller,Richard A.; Talley,John J.; Getman,Daniel P.; DeCrescenzo,Gary A.; Freskos,John N.; Bertenshaw,Deborah E.; Heintz,Robert M., α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  3. Vazquez,Michael L.; Mueller,Richard A.; Talley,John J.; Getman,Daniel P.; DeCrescenzo,Gary A.; Freskos,John N.; Heintz,Robert M.; Bertenshaw,Deborah E., α-and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  4. Michael L. Vazquez ; Richard A. Mueller ; John J. Talley ; Daniel P Getman ; Gary A. DeCrescenzo ; John N. Freskos ; Robert M. Heintz ; Deborah E. Bertenshaw, .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  5. Vazquez, Michael L.; Mueller, Richard A.; Talley, John J.; Getman, Daniel; DeCrescenzo, Gary A.; Freskos, John N., .alpha.- and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  6. Michael L. Vazquez ; Richard A. Mueller ; John J. Talley ; Daniel Getman ; Gary A. DeCrescenzo ; John N. Freskos, .alpha.-and .beta.-amino acid hydroxyethlamino sulfonamides useful as retroviral protease inhibitors.
  7. Michael L. Vazquez ; Richard A. Mueller ; John J. Talley ; Daniel P. Getman ; Gary A. DeCrescenzo ; John N. Freskos ; Deborah E. Bertenshaw ; Robert M. Heintz, .alpha.-and .beta.-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  8. Moon,Joseph B.; Pulley,Shon R.; Rich,Daniel H.; Brown,David L.; Jagodzinska,Barbara; John,Varghese; Jacobs,John, 3,4-disubstituted, 3,5-disubstituted and 3,4,5-substituted piperidines.
  9. Getman, Daniel P; DeCrescenzo, Gary A; Freskos, John N; Vazquez, Michael L; Sikorski, James A; Devadas, Balekudru; Nagarajan, Srinivasan Raj; Brown, David L; McDonald, Joseph J, Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors.
  10. Getman, Daniel P; DeCrescenzo, Gary A; Freskos, John N; Vazquez, Michael L; Sikorski, James A; Devadas, Balekudru; Nagarajan, Srinivasan Raj; Brown, David L; McDonald, Joseph J, Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors.
  11. Getman,Daniel P.; DeCrescenzo,Gary A.; Freskos,John N.; Vazquez,Michael L.; Sikorski,James A.; Devadas,Balekudru; Nagarajan,Srinivasan Raj; Brown,David L.; McDonald,Joseph J., Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors.
  12. Getman,Daniel P; DeCrescenzo,Gary A; Freskos,John N; Vazquez,Michael L; Sikorski,James A; Devadas,Balekudru; Nagarajan,Srinivasan Raj; Brown,David L; McDonald,Joseph J, Bis-amino acid hydroxyethylamino sulfonamide retroviral protease inhibitors.
  13. Kaltenbach, Robert F., Bis-amino acid sulfonamides as HIV protease inhibitors.
  14. Raines, Ronald T.; Windsor, Ian; Palte, Michael; Lukesh, John, Boronic acid inhibitors of HIV protease.
  15. Beck, James; Gailunas, Andrea; Hom, Roy; Jagodinska, Barbara; John, Varghese; Maillaird, Michael, Compounds to treat Alzheimer's disease.
  16. Beck,James P.; Fang,Lawrence Y.; Freskos,John N.; Gailunas,Andrea; Hom,Roy; Jagodzinska,Barbara; John,Varghese; Maillard,Michel; Pulley,Shon R.; TenBrink,Ruth E., Compounds to treat Alzheimer's disease.
  17. Fang,Lawrence Y.; John,Varghese, Compounds to treat Alzheimer's disease.
  18. Hom, Roy; Mamo, Shumeye S.; Tung, Jay; Gailunas, Andrea; John, Varghese; Fang, Lawrence Y., Compounds to treat Alzheimer's disease.
  19. Hom,Roy; Mamo,Shumeye S.; Tung,Jay; Gailunas,Andrea; John,Varghese; Fang,Lawrence Y., Compounds to treat Alzheimer's disease.
  20. Hom,Roy; Mamo,Shumeye; Tung,Jay; Gailunas,Andrea; John,Varghese; Fang,Lawrence, Compounds to treat Alzheimer's disease.
  21. Beck, James P.; Gailunas, Andrea; Hom, Roy; Jagodzinska, Barbara; John, Varghese; Maillard, Michel, Compounds to treat alzheimer's disease.
  22. Erickson, John W.; Gulnik, Sergei V.; Mitsuya, Hiroaki; Ghosh, Arun E., Fitness assay and associated methods.
  23. Erickson,John W.; Gulnik,Sergei V.; Mitsuya,Hiroaki; Ghosh,Arun K., Fitness assay and associated methods.
  24. Flentge, Charles A.; Chen, Hui-Ju; DeGoey, David A.; Flosi, William J.; Grampovnik, David J.; Huang, Peggy P.; Kempf, Dale J.; Klein, Larry L.; Krueger, Allan C.; Madigan, Darold L.; Randolph, John T.; Sun, Minghua; Yeung, Ming C.; Zhao, Chen, HIV protease inhibiting compounds.
  25. Ghosh, Arun K.; Bilcer, Geoffrey M.; Devasamudram, Thippeswamy, HIV protease inhibitors.
  26. Ghosh,Arun K.; Bilcer,Geoffrey M.; Devasamudram,Thippeswamy, HIV protease inhibitors.
  27. Tucker,John A.; Sherer,Brian A.; Xu,Ying Zi; Brogley,Louis; Pulley,Shon R.; Jacobs,Jon S.; Beck,James P.; John,Varghese, Hydroxypropyl amides for the treatment of Alzheimer's disease.
  28. Fisher,Jed F.; Jacobs,Jon S.; Sherer,Brian, Hydroxypropylamines.
  29. Hom,Roy; Mamo,Shumeye S.; Tung,Jay; Gailunas,Andrea; John,Varghese; Fang,Lawrence Y., Methods to treat alzheimer's disease.
  30. Marom, Ehud, Polymorphs of darunavir.
  31. Marom, Ehud, Polymorphs of darunavir.
  32. Mizhiritskii, Michael; Marom, Ehud, Process for the preparation of darunavir and darunavir intermediates.
  33. Erickson,John W.; Eissenstat,Michael; Silva,Abelardo; Gulnik,Sergei, Resistance-repellent retroviral protease inhibitors.
  34. Mueller, Richard A.; Getman, Daniel P., Retroviral protease inhibitors.
  35. Mueller,Richard A; Getman,Daniel P., Retroviral protease inhibitors.
  36. John,Varghese; Hom,Roy; Tucker,John, Substituted alcohols useful in treatment of Alzheimer's disease.
  37. Vazquez, Michael L.; Mueller, Richard A.; Talley, John J.; Getman, Daniel P.; DeCrescenzo, Gary A.; Freskos, John N.; Heintz, Robert M.; Bertenshaw, Deborah E., α- and β- amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  38. Vazquez, Michael L.; Mueller, Richard A.; Talley, John J.; Getman, Daniel P.; DeCrescenzo, Gary A.; Freskos, John N.; Bertenshaw, Deborah E.; Heintz, Robert M., α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  39. Vazquez, Michael L.; Mueller, Richard A.; Talley, John J.; Getman, Daniel P.; DeCrescenzo, Gary A.; Freskos, John N.; Bertenshaw, Deborah E.; Heintz, Robert M., α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  40. Vazquez, Michael L.; Mueller, Richard A.; Talley, John J.; Getman, Daniel P.; DeCrescenzo, Gary A.; Freskos, John N.; Bertenshaw, Deborah E.; Heintz, Robert M., α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  41. Vazquez, Michael L.; Mueller, Richard A.; Talley, John J.; Getman, Daniel P.; DeCrescenzo, Gary A.; Freskos, John N.; Heintz, Robert M.; Bertenshaw, Deborah E., α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  42. Vazquez, Michael L.; Mueller, Richard A.; Talley, John J.; Getman, Daniel P.; DeCrescenzo, Gary A.; Freskos, John N.; Heintz, Robert M.; Bertenshaw, Deborah E., α- and β-amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
  43. Vazquez, Michael L.; Mueller, Richard A.; Talley, John J.; Getman, Daniel P.; DeCrescenzo, Gary A.; Freskos, John N.; Bertenshaw, Deborah E.; Heintz, Robert M., α-and β-Amino acid hydroxyethylamino sulfonamides useful as retroviral protease inhibitors.
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트