IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
|
| 국제특허분류(IPC7판) |
|
| 출원번호 |
US-0284971
(1999-07-08)
|
| 우선권정보 |
FR-0013583 (1996-11-07) |
| 국제출원번호 |
PCT/FR97/01997
(1997-11-06)
|
| §371/§102 date |
19990708
(19990708)
|
| 국제공개번호 |
WO-9819735
(1998-05-14)
|
|
발명자
/ 주소 |
- Muller Daniel,FRX
- Perie Frederic,FRX
- Barbier Alain,FRX
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 |
피인용 횟수 :
46 인용 특허 :
0 |
초록
▼
The device for ionophoresis combines a donor electrode assembly, a counter electrode assembly and a generator of electricity. The donor assembly comprises a primary reservoir element containing the active principle and a secondary reservoir element containing a neutral electrolyte, these reservoir e
The device for ionophoresis combines a donor electrode assembly, a counter electrode assembly and a generator of electricity. The donor assembly comprises a primary reservoir element containing the active principle and a secondary reservoir element containing a neutral electrolyte, these reservoir elements being separated by a semipermeable membrane in polymer material in contact with each of them, and an electrode in contact with the secondary reservoir element. The polymer material of the membrane consists at least in polyethyerblocamide with an Mn between 10000 and 300000 and containing by weight, 35% to 90% of polyamide sequences. The invention is applicable to the transcutaneous administration of active principles to a subject with improved efficiency.
대표청구항
▼
[ What is claimed is:] [1.] Iontophoresis device, for transcutaneous administration of an active principle to a subject, comprising (a) a first electrode assembly, called the donor electrode assembly, consisting of a first electrode called the active electrode, a primary reservoir element designed t
[ What is claimed is:] [1.] Iontophoresis device, for transcutaneous administration of an active principle to a subject, comprising (a) a first electrode assembly, called the donor electrode assembly, consisting of a first electrode called the active electrode, a primary reservoir element designed to contain a primary electrolyte medium containing the active principle in an at least partially ionized form or in a neutral form in order to ensure, when it is placed in contact with an area of the subject's skin, ionically conducting continuity between the said first electrode and the said area, and a membrane made of polymer material in contact, via one face, with the first electrode and, via another face, with the primary reservoir element, the said membrane being selectively permeable to ions and molecules of sizes smaller than a chosen threshold, (b) a second electrode assembly consisting either (i) of a second electrode, called the back electrode, or preferably (ii) of a second electrode of this type in contact with a reservoir element, called the back electrode, designed to contain at least one electrolyte medium and to ensure, when it is placed in contact with a portion of the subject's skin, ionically conducting continuity between the second electrode and the said portion and (c) an electric signal generator which can be connected to each of the said first and second electrodes in such a way that the first electrode has the same polarity as the ions of the active principle or a positive polarity if the said active principle is neutral and that the second electrode has a polarity opposite to that of the first electrode, wherein in the said device the polymer material constituting the selectively permeable membrane consists of at least one polyether block amide formed by identical or different units corresponding to the formula [ STR 6 ] in which A is a polyamide sequence derived, by losing its COOH groups, from a dicarboxylic polyamide having a COOH group at each of the ends of its chain, and B is a polyoxyalkylene sequence derived, by losing two hydroxyl groups, from a polyoxyalkylene glycol whose chain is formed by oxyalkylene units having 2 to 4 carbon atoms and has an OH group at each of its ends, the said polyether block amide having a number-average molecular mass of between 10,000 and 300,000 and containing a proportion by weight of polyamide sequences A of between 35% and 90%.
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