초록 ▼

A device for the separation of the liquid portion of blood from the cellular components of blood comprises: (1) a pad of porous material permeable to the liquid portion of blood but capable of trapping the cellular components of blood; (2) a substrate supporting the pad; and (3) means, attached to t

A device for the separation of the liquid portion of blood from the cellular components of blood comprises: (1) a pad of porous material permeable to the liquid portion of blood but capable of trapping the cellular components of blood; (2) a substrate supporting the pad; and (3) means, attached to the pad, for facilitating the flow of the liquid portion of the blood: (i) through interstices around the trapped cellular components of the blood and (ii) from the pad of porous material. The separation of the liquid portion of blood from the cellular components of the blood occurs by flow through the pad of porous material without significant hemolysis. The device can be incorporated into a device for the performance of specific binding assays such as immunoassays. The pad of porous material can contain an agglutinating agent such as a lectin or an anti-blood cell antibody, or a carbohydrate such as mannitol. Other devices and methods for the separation of the liquid portion of blood from the cellular components of the blood are also disclosed.

대표청구항 ▼

[ We claim:] [1.] A device for separating the liquid portion of blood from the cellular components of blood comprising:(a) a first opposable component including:(i) a first porous separating matrix permeable to the liquid portion of blood but capable of trapping the cellular components of blood; and

[ We claim:] [1.] A device for separating the liquid portion of blood from the cellular components of blood comprising:(a) a first opposable component including:(i) a first porous separating matrix permeable to the liquid portion of blood but capable of trapping the cellular components of blood; and(ii) a second porous matrix in operable contact with the first porous separating matrix that permits the liquid portion of the blood to flow by capillary action through the second porous matrix; and(b) a second opposable component attachable to the first opposable component for applying fluid to the first opposable component such that the first and second opposable components can be brought into opposition to transfer fluid from the second opposable component to the first opposable component by pressure;whereby the separation of the liquid portion of blood from the cellular components of the blood occurs by flow through the first and second matrices of the first opposable component without significant hemolysis.