초록

A process for preparing N-acyl, N-sulfonyl and N-phosphoryl substituted isoserine esters in which a metal alkoxide is reacted with a .beta.-lactam.

대표청구항 ▼

[ What I claim is:] [1.] A metal alkoxide having the formula: [ STR 50 ] wherein M is a metal;E.sub.1 and E.sub.2 and the carbon to which they are attached define a tricyclic taxane nucleus; andE.sub.3 is hydrogen or hydrocarbon. [7.] An alkoxide having the formula: [ STR 51 ] wherein M is a metal;R

[ What I claim is:] [1.] A metal alkoxide having the formula: [ STR 50 ] wherein M is a metal;E.sub.1 and E.sub.2 and the carbon to which they are attached define a tricyclic taxane nucleus; andE.sub.3 is hydrogen or hydrocarbon. [7.] An alkoxide having the formula: [ STR 51 ] wherein M is a metal;R.sub.15 and R.sub.16 are independently hydrogen, hydroxy, lower alkanoyloxy, alkenoyloxy, alkynoyloxy, aryloyloxy or R.sub.15 and R.sub.16 together form an oxo;R.sub.17 and R.sub.18 are independently hydrogen or lower alkanoyloxy, alkenoyloxy, alkynoyloxy, or aryloyloxy or R.sub.17 and R.sub.18 together form an oxo;R.sub.19 and R.sub.20 are independently hydrogen or hydroxy or lower alkanoyloxy, alkenoyloxy, alkynoyloxy, or aryloyloxy;R.sub.21 and R.sub.22 are independently hydrogen or lower alkanoyloxy, alkenoyloxy, alkynoyloxy, or aryloyloxy or R.sub.21 and R.sub.22 together form an oxo;R.sub.24 is hydrogen or hydroxy- or lower alkanoyloxy, alkenoyloxy, alkynoyloxy, or aryloyloxy; orR.sub.23 and R.sub.24 together form an oxo or methylene orR.sub.23 and R.sub.24 together with the carbon atom to which they are attached form an oxirane ring;R.sub.25 is hydrogen, hydroxy, or lower alkanoyloxy, alkenoyloxy, alkynoyloxy, or aryloyloxy; orR.sub.26 is hydrogen, hydroxy, or lower alkanoyloxy, alkenoyloxy, alkynoyloxy, or aryloyloxy; or R.sub.26 and R.sub.25 taken together form an oxo; andR.sub.27 is hydrogen, hydroxy or lower alkoxy, alkanoyloxy, alkenoyloxy, alkynoyloxy, or aryloyloxy.