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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0559957 (1995-11-17) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 512 인용 특허 : 12 |
A system and method for stimulating the baroreflex arc based on levels of indicators from the body includes a pacemaker for bradycardia support pacing should the indicators show the need for support pacing. Other indicators and a process take advantage of an assumed relationship between peripheral v
A system and method for stimulating the baroreflex arc based on levels of indicators from the body includes a pacemaker for bradycardia support pacing should the indicators show the need for support pacing. Other indicators and a process take advantage of an assumed relationship between peripheral vascular resistance and pulmonary resistance to determine the level of nerve stimulation required. This level is adjusted or optimized based on its interaction with heart activity and changes in the other indicators. These other indicators are readily available to the implanted device and allow for a process to make an estimate of pulmonary vascular resistance, from which SVR is also estimated. The value determined for SVR is the primary value used to determine the level of nerve stimulation absent indicators for the need to provide bradicardia pacing. The pacemaker can be rate responsive, as can the process for determining the level of nerve stimulation to be delivered. Several different lead configurations are described.
[ We claim:] [1.] A system for coordinating the stimulation of nerves for controlling the level of neurohormonal activation in a living body having a heart subject to potential or actual pathologic stress levels comprising:an implantable pulse generator with a microprocessor and memory adapted and d
[ We claim:] [1.] A system for coordinating the stimulation of nerves for controlling the level of neurohormonal activation in a living body having a heart subject to potential or actual pathologic stress levels comprising:an implantable pulse generator with a microprocessor and memory adapted and disposed to run a plurality of processes,a sensor for sensing SVO.sub.2 in the body, and a sensor for determining pressure in a ventricle of the heart of the body, both said sensors adapted and disposed to provide readings to said microprocessor for use by said processes,a bradycardia pacer control process included within said pulse generator for pacing the heart when a condition of bradycardia is present so as to prevent insufficient heart rate by said heart,at least one stimulation electrode connected to effectively deliver electrical stimulation to a baroreceptor nerve site,an adjustment process for monitoring heart rate and estimating PVR from said SVO.sub.2 and pressure so as to determine appropriate modifications to the stimulation output to said stimulation electrode, andmeans for making said modifications.
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