[특허]1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics

[미국특허] 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-031/437 C07D-047/104
출원번호	US-0284070 (1999-04-07)
우선권정보	FR-0012229 (1996-10-08)
국제출원번호	PCT/FR97/01750 (1997-10-08)
§371/§102 date	19990407 (19990407)
국제공개번호	WO-9815552 (1998-04-16)
발명자 / 주소	Evanno Yannick,FRX Sevrin Mireille,FRX Maloizel Christian,FRX Legalloudec Odette,FRX George Pascal,FRX
출원인 / 주소	Synthelabo, FRX
대리인 / 주소	Finnegan, Henderson, Farabow, Garrett & Dunner, L.L.P.
인용정보	피인용 횟수 : 12 인용 특허 : 0

초록

Compounds of general formula (I) [ STR 1 ] in which the variables are as defined in the specification, their preparation and their application in therapeutics.

대표청구항 ▼

[ We claim:] [1.] A compound having general formula (I) [ STR 7 ] in which X represents a hydrogen or halogen atom or a (C.sub.1 -C.sub.3)alkyl, (C.sub.1 -C.sub.3)alkoxy, trifluoromethyl or phenylmethoxy group,R.sub.1 represents a hydrogen atom or a (C.sub.1 -C.sub.3)alkyl, cyclopropyl or phenylmethyl group,R.sub.2 represents either a (C.sub.1 -C.sub.3)alkyl group optionally substituted by a methoxy group, or a phenyl(C.sub.1 -C.sub.3)alkyl group optionally substituted on the phenyl ring by a halogen atom or a methyl or methoxy group, or a cyclohexylmethyl group, or a thienylmethyl group, or a pyridinylmethyl group, or a phenyl group optionally substituted by one or more halogen atoms or a (C.sub.1 -C.sub.3)alkyl or (C.sub.1 -C.sub.3)alkoxy group, or a pyridinyl group, or a 5-methyl-1,2-oxazolyl group, or a 5-methyl-1,3,4-thiadiazolyl group, or a naphthyl group,R.sub.3 and R.sub.4, independently of one another, each represent a hydrogen atom, a (C.sub.1 -C.sub.3)alkyl group, a 2-methoxyethyl group, a hydroxy(C.sub.2 -C.sub.4) alkyl group, a carboxy-(C.sub.1 -C.sub.3)alkyl group, a (C.sub.1 -C.sub.3)alkoxycarbonyl(C.sub.1 -C.sub.3)alkyl group or a phenyl(C.sub.1 -C.sub.3)alkyl group, or else together form, with the nitrogen atom which carries them, either a pyrrolidinyl group optionally substituted by a hydroxyl, ethoxy, methoxycarbonyl or methoxymethyl group, or a piperidinyl group, or a morpholinyl group, or a 4-methylpiperazinyl group, or an azetidinyl group, or a thiazolidinyl group, and the bond between the carbon atoms in the 3 and 4 positions is single or double.

이 특허를 인용한 특허 (12) 인용/피인용 타임라인 분석

Burnier, Philippe; Froissant, Jacques; Marabout, Benoit; Marguet, Frank; Puech, Frederic, 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-B]indole-1-carboxamide derivatives, their preparation and therapeutic use.
상세보기
Froissant,Jacques; Marabout,Benoit; Marguet,Frank; Puech,Frederic, 3-Heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b]indole-1-acetamide derivatives, their preparation and their application in therapeutics.
상세보기
Burnier,Philippe; Froissant,Jacques; Marabout,Beno챤t; Marguet,Frank; Puech,Fr챕d챕ric, 3-heteroaryl-3, 5-dihydro-4-oxo-4H-pyridazino[4, 5-b]indole-1-carboxamide derivatives their preparations and therapeutic use.
상세보기
Burnier,Philippe; Froissant,Jacques; Marabout,Benoit; Marguet,Frank; Puech,Frederic, 3-heteroaryl-3,5-dihydro-4-oxo-4-pyridazino[4,5-B] indole-1-carboxamide derivatives, their preparation and therapeutic use.
상세보기
Froissant,Jacques; Marabout,Benoit; Marguet,Frank; Puech,Frederic, 3-heteroaryl-3,5-dihydro-4-oxo-4-pyridazino[4,5-b] indole-1-acetamide derivatives, their preparation and their application in therapeutics.
상세보기
Froissant,Jacques; Marabout,Beno？t; Marguet,Frank; Puech,Fr？d？ric, 3-heteroaryl-3,5-dihydro-4-oxo-4H-pyridazino[4,5-b] indole-1-acetamide derivatives, preparation and use thereof in medicaments.
상세보기
Evanno Yannick,FRX ; Dubois Laurent,FRX ; Sevrin Mireille,FRX ; Marguet Frank,FRX ; Froissant Jacques,FRX ; Bartsch Regine,FRX ; Gille Catherine,FRX, 4-Oxo-3,5-dihydro-4H-pyridazino[4,5-b]-indole-1-acetamide derivatives, their preparation and their application in therapy.
상세보기
Kuki,Atsuo; Li,Xinqiang; Plewe,Michael Bruno; Wang,Hai; Zhang,Junhu, HIV integrase inhibitors, pharmaceutical compositions and methods for their use.
상세보기
Hu,Qiyue; Kuki,Atsuo; Nowlin,Dawn Marie; Plewe,Michael Bruno; Wang,Hai; Zhang,Junhu, HIV-Integrase inhibitors, pharmaceutical compositions and methods for their use.
상세보기
Kuki,Atsuo; Li,Xinqiang; Plewe,Michael Bruno; Wang,Hai; Zhang,Junhu, HIV-integrase inhibitors, pharmaceutical compositions, and methods for their use.
상세보기
Dress, Klaus Ruprecht; Hu, Qiyue; Johnson, Ted William; Plewe, Michael Bruno; Tanis, Steven Paul; Zhu, Huichun; Zhang, Junhu, Inhibitors of the HIV integrase enzyme.
상세보기
Dress,Klaus Ruprecht; Hu,Qiyue; Johnson,Ted William; Plewe,Michael Bruno; Tanis,Steven Paul; Wang,Hai; Yang,Anle; Yin,Chunfeng; Zhang,Junhu, Inhibitors of the HIV integrase enzyme.
상세보기

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics 원문보기