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Systems and processes for spray drying hydrophobic drugs with hydrophilic excipients 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
  • A61K-009/72
출원번호 US-0999097 (1997-12-29)
발명자 / 주소
  • Gordon Marc S.
  • Clark Andrew
  • Brewer Thomas K.
출원인 / 주소
  • Inhale Therapeutic Systems
대리인 / 주소
    Townsend & Townsend & Crew
인용정보 피인용 횟수 : 148  인용 특허 : 13

초록

Methods for preparing dry powders having hydrophobic and hydrophilic components comprise combining solutions of the components and spray drying them simultaneously in a spray dryer. The hydrophilic and hydrophobic component are separately dissolved in separate solvents and directed simultaneously th

대표청구항

[ What is claimed is:] [1.] A method for preparing a dry powder composition, said method comprising:preparing an aqueous solution of a hydrophilic component;preparing an organic solution of a hydrophobic component in an organic solvent; anddelivering the aqueous solution containing the hydrophilic c

이 특허에 인용된 특허 (13)

  1. Ganderton David (Exeter GB2) Kassem Nuha M. (London GB2), Aerosol carriers.
  2. Boardman Terence D. (Davenham GB2) Forrester Raymond B. (Sandbach GB2), Inhalation pharmaceuticals.
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  5. De Castro Lan (West Chester PA), Method of preparing stable drug nanoparticles.
  6. Uda Yoshiaki (Takarazuka JPX) Hirai Shin-ichiro (Kyoto JPX) Yashiki Takatsuka (Takarazuka JPX), Pharmaceutical composition and its rectal use.
  7. Bosch H. William (Bryn Mawr PA) Marcera Donna M. (Collegeville PA) Mueller Ronald L. (Downingtown PA) Swanson Jon R. (Macungie PA) Mishra Dinesh S. (Harleysville PA), Process for preparing therapeutic compositions containing nanoparticles.
  8. Kilbride ; Jr. Terence K. (Bloomfield Hills MI) Lisa Rudolph E. (Grosse Ile MI), Process for spray drying riboflavin to produce a granulate product having low binder content.
  9. Motoyama, Shimesu; Sato, Satashi; Umeda, Seiichi; Yasumi, Hirotsune; Suto, Emiko; Takasaka, Yuko; Tsujino, Takuichi, Process for the preparation of activated pharmaceutical compositions.
  10. Aeschbach Robert (Vevey CHX) Philippossian Georges (Lausanne CHX), Process for the preparation of an antioxydant extract of spices.
  11. Schmidt Douglass N. (Grosse Ile MI) Finnan Jeffrey L. (Southgate MI) Lisa Rudolph E. (Grosse Ile MI), Spray-dried vitamin powders using hydrophobic silica.
  12. Kogan Patricia W. (Union NJ) Rudnic Edward M. (Boca Raton FL) Sequeira Joel A. (New York NY) Chaudry Imtiaz A. (Denville NJ), Sustained release oral suspensions.
  13. Onouchi Takashi (Tokyo JPX) Sugai Hironori (Yokohama JPX) Sekiguchi Kazuo (Nagareyama JPX) Hosoda Yoshikazu (Fujisawa JPX) Yoshida Eiichi (Tokyo JPX), Water-soluble microcapsules.

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