초록 ▼

The present invention is a system and method for freeze granulation of a medium such as a biopharmeceutical product. The medium is put into a chamber and mixed using a pair of counter rotating agitators. The agitators have angled blades or paddles on them in order to induce motion in the medium para

The present invention is a system and method for freeze granulation of a medium such as a biopharmeceutical product. The medium is put into a chamber and mixed using a pair of counter rotating agitators. The agitators have angled blades or paddles on them in order to induce motion in the medium parallel to the axis of the agitator shafts. A set of liquid nitrogen and liquid carbon dioxide nozzles are attached to the chamber. The liquid nitrogen nozzles spray a mist of liquid nitrogen into the medium. The liquid carbon dioxide nozzles spray carbon dioxide snow into the chamber. The liquid nitrogen and the carbon dioxide can be sprayed into the chamber at the same time or alternately.

대표청구항 ▼

[ What is claimed is:] [1.] A method for cryopreservation of a medium in a chamber, comprising:introducing a carbon dioxide snow into the chamber;introducing a liquid nitrogen mist into the chamber after the introduction of carbon dioxide snow into the chamber has stopped; andmixing the medium produ

[ What is claimed is:] [1.] A method for cryopreservation of a medium in a chamber, comprising:introducing a carbon dioxide snow into the chamber;introducing a liquid nitrogen mist into the chamber after the introduction of carbon dioxide snow into the chamber has stopped; andmixing the medium product until it is cryopreserved.