IPC분류정보
| 국가/구분 |
United States(US) Patent
등록
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| 국제특허분류(IPC7판) |
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| 출원번호 |
US-0920372
(1997-08-29)
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발명자
/ 주소 |
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| 출원인 / 주소 |
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| 인용정보 |
피인용 횟수 :
0 인용 특허 :
18 |
초록
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This invention is directed to novel nucleophilic polysubstituted aryl acridinium conjugates and the methods for preparation thereof. The novel nucleophilic polysubstituted aryl acridinium conjugates are useful in biological assays, including novel assays for the determination of Vitamin B.sub.12, fo
This invention is directed to novel nucleophilic polysubstituted aryl acridinium conjugates and the methods for preparation thereof. The novel nucleophilic polysubstituted aryl acridinium conjugates are useful in biological assays, including novel assays for the determination of Vitamin B.sub.12, folate, cortisol, estradiol, and thromboxane B.sub.2.
대표청구항
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[ What is claimed is:] [1.] A luminescent conjugate comprising an acridinium ester bound to a specific binding member where the acridinium ester has the formula: [ STR 21 ] wherein: X.sup.- is an anion;R.sub.1 is (a) attached to the ring nitrogen of the acridine nucleus of the acridinium ester throu
[ What is claimed is:] [1.] A luminescent conjugate comprising an acridinium ester bound to a specific binding member where the acridinium ester has the formula: [ STR 21 ] wherein: X.sup.- is an anion;R.sub.1 is (a) attached to the ring nitrogen of the acridine nucleus of the acridinium ester through a carbon, (b) comprises up to 20 heteroatoms, and (c) is selected from the group consisting of alkenyl, alkyl, alkynyl, aralkyl, and aryl;R.sub.2, R.sub.3, R.sub.5, and R.sub.7 are selected from the group consisting of alkoxyl, amino, halide, hydrogen, hydroxyl, nitro, --CN, [ STR 22 ] --SCN, --COOH, and --SO.sub.3 H;R.sub.4 and R.sub.8 are selected from the group consisting of alkenyl, alkoxyl, alkyl, alkynyl, and aralkyl;R.sub.6 is selected from the group consisting of Q--R--Nu, [ STR 23 ] and Q--Nu where: Nu is a nucleophilic group;Q is selected from the group consisting of diazo, [ STR 24 ] and --NH--; and I is selected from the group consisting of --SO.sub.3 H, --OSO.sub.3 H, --PO(OH).sub.2, --COOH, and --OPO(OH).sub.2 ; ept that, where R.sub.6 .dbd.QNu, the condition where Q.dbd. [ STR 25 ] and Nu.dbd.--OH is excluded; and R comprises up to 20 heteroatoms and is selected from the group consisting of alkenyl, alkyl, alkynyl, aralkyl, and aryl.
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