[특허]Method of preparing a dosage unit by direct tableting and product therefrom

Method of preparing a dosage unit by direct tableting and product therefrom 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/14
출원번호	US-0642026 (1996-04-29)
발명자 / 주소	Fuisz Richard C. Myers Garry L. Yang Robert K. Herman Mark R. Cavanagh Whitney S. Sisak John R. Brothers Andrea S.
출원인 / 주소	Fuisz Technologies Ltd.
대리인 / 주소	Levis
인용정보	피인용 횟수 : 14 인용 특허 : 22

초록 ▼

The present invention is a process and apparatus for making a dosage unit by direct tableting of shearlite particles. The present invention also includes the dosage unit itself. Shearlite particles, which are prepared by subjecting a feedstock material to liquiflash processing, can be directly fed from a shearlite device to a tableting apparatus without the necessity of any intermediate steps or additional ingredients to facilitate flowability or tablet formation.

대표청구항 ▼

[ What is claimed:] [1.] A process for making a dosage unit, which comprises:directly tableting shearlite particles without intermediate processing or additional ingredients sufficiently to form a dosage unit, wherein said shearlite particles are provided by the process including the steps of:a) subjecting a solid, organic-based feedstock, capable of being transformed to a liquiform in the substantial absence of dissolving medium, to liquiflash conditions which transforms said feedstock from a solid to a liquid to a solid under conditions of heat and centrifugal force to provide substantially unimpeded internal flow of said feedstock while liquefied and said liquefied feedstock having a viscosity such that all impedance to form liquid droplets is eliminated; said transformation occurring in not greater than five (5) seconds; andb) imparting shear force on said flowing feedstock in step "a" in an amount sufficient to separate particles by natural mass separation of said flowing feedstock in the presence of said shear force impinging thereon while in said unimpeded-flow condition.

이 특허에 인용된 특허 (22)

Benton Ben F. (Centerburg OH) Gardner David L. (Bellville OH), Controlled release liquid dosage formulation.
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Kleinberg Israel (Smithtown NY) Sreebny Leo M. (East Setauket NY), Device for stimulating salivation.
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Wetterlin Kjell I. L. (S Sandby SEX), Dosage inhalator.
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Lu Jieh-Shan (No. 23 ; Lane 783 ; Wen Hwa Road Nan Tou City ; Nan Tou Hsien TWX), Drug-feeder for children.
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Myers Garry L. (Reston VA) Yang Robert K. (Flushing NY) Herman Mark R. (Nokesville VA), Liquiflash particles and method of making same.
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Perkins James H. (Boyce VA) Rutkowski William F. (Arlington VA) Love Michael L. (Arlington VA) Myers Garry L. (Reston VA), Method and apparatus for spinning feedstock material.
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Brandau Egbert (Alzenau DEX) Huschka Hans (Hanau DEX) Kadner Martin (Maintal DEX) Schrder Waldemar (Hasselroth DEX), Method for manufacturing spherical particles out of liquid phase.
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Spector John E. (2404 Sacada Cir. La Costa CA 92009), Method for oral spray administration of caffeine.
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Kokubo Hiroyasu (Niigata JPX) Muto Hiroaki (Niigata JPX) Chiba Tohru (Niigata JPX), Method for the preparation of coated solid medicament form.
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Fuisz Richard C. (Washington DC), Method of producing compacted dispersable systems.
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Setterstrom Jean A. (Silver Spring MD) Jacob Elliot (Silver Spring MD) Franz Walter K. (Annapolis MD), Microsphere drug application device.
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Fuisz Richard C., Polydextrose product and process.
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Barrington James E. (Woburn MA) Williams David L. (Reading MA) Hitchcock Charles J. (Cambridge MA) Mullins Thomas J. (Woburn MA), Powder blower device.
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Sipos ; Tibor, Preparation of enteric coated digestive enzyme compositions.
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Ueda Setsuo (Chigasaki JPX) Yasuda Takashi (Aichi JPX) Yamada Tokuyoshi (Nagoya JPX) Kobayashi Shigeki (Tokai JPX), Process and apparatus for producing spherical particles and fibers with a specially fixed size from melts.
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Blichare Mitchell S. (Blauvelt NY) Jackson ; Jr. Gerald J. (Berdonia NY), Process for preparing oral sustained release granules.
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Cousin Grard (Gallardon FRX) Bruna Etienne (Chartres FRX) Gendrot Edouard (Vernouillet FRX), Rapidly disintegratable multiparticular tablet.
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Fuisz Richard C. (Bethlehem PA), Rapidly dissoluble medicinal dosage unit and method of manufacture.
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Kitanishi Yasuhisa (Hino JPX) Taniguchi Hiroaki (Zama JPX) Kochi Tsuyoshi (Hino JPX), Slow-releasing granules and long acting mixed granules comprising the same.
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Steber William (Ledgewood NJ), Stable compositions for parenteral administration and method of making same.
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Barry Brian W. (Leeds GBX) Mulley Bryan A. (Bradford GBX) York Peter (Ilkley GBX), Sustained-release formulations.
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Illum Lisbeth (The Park GBX), Transmucosal formulations of low molecular weight peptide drugs.
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이 특허를 인용한 특허 (14)

Hagen,Timothy A.; Lo,Julian B.; Thombre,Avinash G.; Herbig,Scott M.; Appel,Leah Elizabeth; Crew,Marshall David; Friesen,Dwayne Thomas; Lyon,David Keith; McCray,Scott Baldwin; West,James Blair, Azithromycin dosage forms with reduced side effects.
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Parhar, Amrit K.; Bush, Charles N., Bonding compositions for chlorinated polymers and methods of using the same.
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Ray, Roderick J.; Appel, Leah E.; Newbold, David D.; Friesen, Dwayne T.; McCray, Scott B.; Lyon, David K.; West, James B.; Crew, Marshall D.; Shockey, Joshua R., Extrusion process for forming chemically stable drug multiparticulates.
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Pourdeyhimi,Behnam; Holmes,Rory; Little,Trevor J., Fiber-based nano drug delivery systems (NDDS).
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Szymczak, Christopher E., Film forming compositions containing sucralose.
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Gulian, Cynthia; Gowan, Jr., Walter G.; Parekh, Kishor B.; Morris, Joseph M.; Markley, Thomas J.; Wieand, Dennis C.; McNally, Gerard P.; Szymczak, Christopher, Method for dip coating dosage forms.
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Appel, Leah E.; Ray, Roderick J.; Lyon, David K.; West, James B.; McCray, Scott B.; Crew, Marshall D.; Friesen, Dwayne T.; Herbig, Scott M.; Lo, Julian B., Multiparticulate crystalline drug compositions having controlled release profiles.
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Kamath,Satish, Polyacrylic film forming compositions.
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Yeh, Ta-Shuong; Yeh, Daniel Hungting, Process for the preparation of direct tabletting formulations and aids.
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Mezaache, Naima; Frisbee, Steven E.; Woodall, Patrick B.; Herman, Mark R., Quick dissolve compositions and tablets based thereon.
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Mezaache, Naima; Frisbee, Steven E.; Woodall, Patrick B.; Herman, Mark R.; Mezaache, Djelila, Quick dissolve compositions and tablets based thereon.
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Grimshaw,Michael N.; Barbieri,Donald J.; Vizzini,Louise M.; Marsh,Steve F., Rapidly disintegrable tablets.
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Grimshaw,Michael N.; Barbieri,Donald J.; Vizzini,Louise M.; Marsh,Steve F., Rapidly disintegrable tablets.
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Fuisz, Richard C., Smokeless tobacco product.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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Method of preparing a dosage unit by direct tableting and product therefrom 원문보기