초록 ▼

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive sp

A small diameter flexible electrode designed for subcutaneous in vivo amperometric monitoring of glucose is described. The electrode is designed to allow "one-point" in vivo calibration, i.e., to have zero output current at zero glucose concentration, even in the presence of other electroreactive species of serum or blood. The electrode is preferably three or four-layered, with the layers serially deposited within a recess upon the tip of a polyamide insulated gold wire. A first glucose concentration-to-current transducing layer is overcoated with an electrically insulating and glucose flux limiting layer (second layer) on which, optionally, an immobilized interference-eliminating horseradish peroxidase based film is deposited (third layer). An outer (fourth) layer is biocompatible.

대표청구항 ▼

[ We claim:] [1.] An analyte measurement system, comprising:a fiber configured and arranged for subcutaneous implantation of a portion of the fiber in a person and for acquisition of an analyte-containing sample of fluid from the person;an electrochemical sensor configured and arranged for dispositi

[ We claim:] [1.] An analyte measurement system, comprising:a fiber configured and arranged for subcutaneous implantation of a portion of the fiber in a person and for acquisition of an analyte-containing sample of fluid from the person;an electrochemical sensor configured and arranged for disposition in fluid communication with the fiber to receive the analyte-containing sample of fluid directly from the person, the electrochemical sensor comprisinga non-corroding working electrode, anda sensing layer disposed on the non-corroding working electrode, the sensing layer comprising a non-leachable, analyte-responsive enzyme.