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특허 상세정보

Reversible gelling culture media for in-vitro cell culture in three-dimensional matrices

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) C12N-005/06    C12N-005/08    C12N-011/04   
미국특허분류(USC) 43/5395 ; 42/409.37 ; 43/518.2 ; 43/539.6 ; 43/539.7 ; 43/540.4
출원번호 US-0062483 (1998-04-17)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Zimmerman
인용정보 피인용 횟수 : 35  인용 특허 : 1
초록

A gelling cell culture medium useful for forming a three dimensional matrix for cell culture in vitro is prepared by copolymerizing an acrylamide derivative with a hydrophilic comonomer to form a reversible (preferably thermally reversible) gelling linear random copolymer in the form of a plurality of linear chains having a plurality of molecular weights greater than or equal to a minimum gelling molecular weight cutoff, mixing the copolymer with an aqueous solvent to form a reversible gelling solution and adding a cell culture medium to the gelling solu...

대표
청구항

[ We claim:] [1.] A gelling cell culture medium, useful for forming a three dimensional matrix for cell culture in vitro, the gelling cell culture medium, comprising:(a) a reversible gelling copolymer that is a linear random copolymer of:(i) a monomer selected from the group consisting of an acrylamide derivative, a methacrylamide derivative and combinations thereof; and(ii) a hydrophilic comonomer different from said monomer in (i);said linear random copolymer in the form of a plurality of linear chains having a plurality of molecular weights greater th...

이 특허를 인용한 특허 피인용횟수: 35

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  2. Story, Brooks J.; Binette, Francois; Brown, M. E. Liesbeth. Chondrocyte container and method of use. USP2013118592201.
  3. Binette, Francois; Story, Brooks J.. Chondrocyte therapeutic delivery system. USP2013038394369.
  4. Binette, Francois; Story, Brooks J.. Chondrocyte therapeutic delivery system. USP2012048153117.
  5. Binette, Francois; Story, Brooks J.. Chondrocyte therapeutic delivery system. USP2011037897384.
  6. Story, Brooks J.; Binette, Francois; Brown, M. E. Liesbeth. Chondrocyte therapeutic delivery system. USP2013018354100.
  7. Story, Brooks J.; Brown, M. E. Liesbeth; Binette, Francois. Chondrocyte therapeutic delivery system. USP2015099125888.
  8. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for administering compartmentalized frozen particles. USP2013108545857.
  9. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for administering compartmentalized frozen particles. USP2013108563012.
  10. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for administering compartmentalized frozen particles. USP2013108551506.
  11. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for administering compartmentalized frozen particles. USP2013128603494.
  12. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2013128603495.
  13. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2013128603496.
  14. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2013108545806.
  15. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2014058731842.
  16. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2013128613937.
  17. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2012078221480.
  18. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for biological remodeling with frozen particle compositions. USP2014078788212.
  19. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for delivery of frozen particle adhesives. USP2015069056047.
  20. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for delivery of frozen particle adhesives. USP2015069050251.
  21. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for delivery of frozen particle adhesives. USP2013108545856.
  22. Boyden, Edward S.; Cook, Daniel B.; Hyde, Roderick A.; Leuthardt, Eric C.; Myhrvold, Nathan P.; Sweeney, Elizabeth A.; Wood, Jr., Lowell L.. Compositions and methods for delivery of frozen particle adhesives. USP2015069060931.
  23. Gaeckle, Markus; Maas, Helmut; Wolf, Daniel; Riehl, Tanja. Corneal epithelial pocket formation systems, components and methods. USP2011027883520.
  24. Marmo, J. Christopher. Corneal onlays and wavefront aberration correction to enhance vision. USP2009097585075.
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  26. Marga, Francoise Suzanne; Purcell, Brendan Patrick; Forgacs, Gabor; Forgacs, Andras. Edible and animal-product-free microcarriers for engineered meat. USP2017099752122.
  27. Forgacs, Gabor; Marga, Francoise; Jakab, Karoly Robert. Engineered comestible meat. USP2014048703216.
  28. Boland,Thomas; Wilson, Jr.,William Crisp; Xu,Tao. Ink-jet printing of viable cells. USP2006057051654.
  29. Marmo, J. Christopher; Back, Arthur; Hollrigel, Greg S.. Inserting lenses into corneal epithelial pockets to improve vision. USP2010117828844.
  30. Metters, Andrew T.; Chollangi, Srinivas. Ligand-mediated controlled drug delivery. USP2012038128952.
  31. Canton, Irene; Armes, Steven Peter; Warren, Nicholas John; Moore, Harry; Battaglia, Giuseppe; Cecchin, Denis. Media for stem cells. USP20181210150946.
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  33. Phillips, Frank Martin. Method of intervertebral disc treatment using articular chondrocyte cells. USP2014048697139.
  34. Arai, Fumihito; Fukuda, Toshio; Ichikawa, Akihiko; Katsuragi, Tohoru. Method or apparatus for recovering micromaterial. USP2010117824854.
  35. Alexander, Cameron; Shakesheff, Kevin; He, Liang; Davies, Martyn; Wang, Wenxin; Saunders, Brian. Polymer particles prepared from polymerisable alkylene glycol (meth) acrylate monomers. USP2015018940336.