초록

The invention relates to new porphyrin complex compounds, pharmaceutical agents that contain the latter, and the use of porphyrin complexes for the production of agents for photodynamic therapy and MRI diagnosis.

대표청구항 ▼

[ What is claimed is:] [1.] A metalloporphyrin complex compound according to formula I [ STR 3 ] wherein M is an ion of a diagmagnetic metal,R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each, independently of one another, a hydrogen atom, a C.sub.1 -C.sub.30 alkyl, a C.sub.1 -C.sub.30 alkyl which is in

[ What is claimed is:] [1.] A metalloporphyrin complex compound according to formula I [ STR 3 ] wherein M is an ion of a diagmagnetic metal,R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are each, independently of one another, a hydrogen atom, a C.sub.1 -C.sub.30 alkyl, a C.sub.1 -C.sub.30 alkyl which is interrupted by 1-10 oxygen atoms, a C.sub.1 -C.sub.30 alkyl which is substituted with 1-5 hydroxy groups or 1-2 COOH groups, or a C.sub.1 -C.sub.30 alkyl which is interrupted by 1-10 oxygen atoms and substituted by 1-5 hydroxy groups or 1-2-COOH groups,R.sup.5 is --(O).sub.0,1 --L--NH--K,L is a straight-chain or branched C.sub.1 -C.sub.20 alkylene, which optionally is interrupted by 1-8 oxygen atoms, 1-5 NH groups, 1-5 CO groups, 1-5 NHCO groups, 1-5 CONH groups or 1-3 sulfur atoms, or L is 1-2 phenylene groups,K is a complexing agent of formulae (IIa), (IIb), (IIc) or (IId), [ STR 4 ] q is 0 or 1, A.sup.2 is phenylene, --CH.sub.2 --NHCO--CH.sub.2 --CH(CH.sub.2 COOH)--C.sub.6 H.sub.4, phenylenoxy, or C.sub.1 -C.sub.12 or C.sub.7 -C.sub.12 alkylene group that is optionally interrupted by one or more oxygen atoms, 1 to 3 --NHCO groups, 1 to 3 --CONH groups and/or substituted with 1 to 3 --(CH.sub.2).sub.0-5 COOH groups,X is --CO or --NHCS,R.sup.6 is a hydrogen atom, straight-chain or branched C.sub.1 -C.sub.7 alkyl, phenyl or benzyl, andL.sup.1, L.sup.2, L.sup.3 and L.sup.4 are each, independently of one another, a hydrogen atom or a metal ion equivalent of an element of atomic numbers 20-32, 37-39, 42-51, or 57-83, vided that at least two of L.sup.1, L.sup.2, L.sup.3 and L.sup.4 stand for said metal ion equivalents and that other anions are present to compensate for optionally present charges in the metalloporphyrin, and in which free carboxylic acid groups that are not required for complexing are optionally present, in each case, as salts with physiologically compatible inorganic cations, as salts with physiologically compatible organic cations, as esters, or as amides.