초록 ▼

A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment

A disposable package, tape, and cassette are provided which makes it possible to hold and disperse therefrom liquid, flowable formulations including aqueous formulations (solutions or dispersions with particles less than 0.25 microns in diameter) of a pharmaceutically active drug. In one embodiment formulation is packaged in individual dosage unit containers which containers are preferably interconnected. The package is designed to be integrated into a cassette which can be loaded into a dispersing device capable of individually opening dosage unit containers and aerosolizing the contents through a porous membrane, into a mouth piece on the cassette, for delivery to a patient. In addition to and alongside of each porous membrane, the package may include one or more openings through which air is forced in order to aid in avoiding the accumulation of aerosolized particles. The package may be configured so that the formulation is held in a container not positioned directly vertical to and below the porous membrane, thus making it necessary to channel formulation horizontally to the porous membrane and making it possible to include a vibrating mechanism directly below a chamber covered by the porous membrane. Release of aerosolized drug is breath actuated based on simultaneous measurements of inspiratory flow and volume so as to provide for repeatable dosing of drug to the patient.

대표청구항 ▼

[ What is claimed is:] [1.] An elongated flexible tape member comprising a tape body comprised of a polymer material forming an interconnecting body sheet wherein the interconnecting body sheet has a thickness in a range of about 2 to about 20 microns and comprises a non-porous sheet area and a plur

[ What is claimed is:] [1.] An elongated flexible tape member comprising a tape body comprised of a polymer material forming an interconnecting body sheet wherein the interconnecting body sheet has a thickness in a range of about 2 to about 20 microns and comprises a non-porous sheet area and a plurality of porous membrane areas having pores therein which pores have a diameter in a range of from about 0.25 microns to about 6 microns wherein the pores are present in each area in a pore density of from about 10 to 10,000 pores over an area in a range of about 1 sq. mm to about 1 sq. cm and wherein the non-porous sheet area comprises a plurality of perforations along an edge for moving the tape through a device from one porous area to another.