초록 ▼

A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cav

A body 300 having a cavity 310 for mounting a substrate 120 fabricated with probe sequences at known locations according to the methods disclosed in U.S. Pat. No. 5,143,854 and PCT WO 92/10092 or others, is provided. The cavity includes inlets 350 and 360 for introducing selected fluids into the cavity to contact the probes. Accordingly, a commercially feasible device for use in high throughput assay systems is provided.

대표청구항 ▼

[ What is claimed is:] [1.] A method of packaging probe arrays, comprising the steps of:forming a plurality of probe arrays on a surface of a rigid and flat substrate having a plurality of alignment marks disposed on the surface, by coupling selected monomers or biopolymers to said substrate whereby

[ What is claimed is:] [1.] A method of packaging probe arrays, comprising the steps of:forming a plurality of probe arrays on a surface of a rigid and flat substrate having a plurality of alignment marks disposed on the surface, by coupling selected monomers or biopolymers to said substrate whereby a plurality of different biopolymer sequences are formed at different known locations each having area of less than 10.sup.-1 cm.sup.2 on said surface of said substrate;separating said rigid and flat substrate along lines determined by the alignment marks into a plurality of individual probe arrays, said individual probe arrays comprising greater than 100 probes; andinseparably mating at least one of said individual probe arrays to a housing, said housing comprising a reaction chamber, said reaction chamber comprising an inlet for flowing fluid into said reaction chamber, and said at least one probe array being in fluid communication with said reaction chamber.