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2'-O-acetamido modified monomers and oligomers 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/02
출원번호 US-0378568 (1999-08-19)
발명자 / 주소
  • Manoharan Muthiah
  • Kawasaki Andrew M.
  • Cook Phillip Dan
  • Fraser Allister S.
  • Prakash Thazha P.
출원인 / 주소
  • Isis Pharmaceuticals, Inc.
대리인 / 주소
    Woodcock Washburn Kurtz Mackieicz & Norris LLP
인용정보 피인용 횟수 : 135  인용 특허 : 100

초록 ▼

Nucleosidic monomers and oligomeric compounds prepared therefrom are provided. Also provided is a novel method of deprotection of oligomeric compounds. Oligomeric compounds having at least one 2'-O-acetamido modified nucleosidic monomer are expected to have increased nuclease resistance and binding

대표청구항 ▼

[ What is claimed is:] [1.] A compound having the formula: [ STR 7 ] wherein: Bx is an optionally protected heterocyclic base moiety;each T.sub.1 and T.sub.2 is, independently, OH, a protected hydroxyl;or one of T.sub.1 and T.sub.2 is OH or a protected hydroxyl and the other of T.sub.1 and T.sub.2 i

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    27. Yamada, Christina; Khvorova, Anastasia; Kaiser, Rob; Anderson, Emily; Leake, Devin, Duplex oligonucleotide complexes and methods for gene silencing by RNA interference.
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    28. Khvorova, Anastasia; Leake, Devin; Robertson, Barbara; Vermeulen, Annaleen; Yamada, Christina, Duplex oligonucleotides with enhanced functionality in gene regulation.
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    29. Wada, Takeshi; Shimizu, Mamoru, Method for the synthesis of phosphorus atom modified nucleic acids.
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    30. Wada, Takeshi; Shimizu, Mamoru, Method for the synthesis of phosphorus atom modified nucleic acids.
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    31. Verdine, Gregory L.; Meena; Iwamoto, Naoki; Butler, David Charles Donnell, Methods for the synthesis of functionalized nucleic acids.
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    32. Prakash, Thazha P.; Manoharan, Muthiah, Methods of modulating pharmacokinetics of oligonucleotides.
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    33. Leake, Devin; Reynolds, Angela R; Khvorova, Anastasia; Marshall, William, Modified polynucleotides for reducing off-target effects in RNA interference.
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    34. Leake, Devin; Reynolds, Angela; Khvorova, Anastasia; Marshall, William; Linsley, Peter S., Modified polynucleotides for reducing off-target effects in RNA interference.
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    35. Hung, Gene; Bennett, C. Frank; Freier, Susan M.; Kordasiewicz, Holly; Stanek, Lisa; Cleveland, Don W.; Cheng, Seng H.; Shihabuddin, Lamya, Modulation of huntingtin expression.
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    36. Hung, Gene; Bennett, C. Frank; Freier, Susan M.; Kordasiewicz, Holly; Stanek, Lisa; Cleveland, Don W.; Cheng, Seng H.; Shihabuddin, Lamya, Modulation of huntingtin expression.
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    37. Hung, Gene; Bennett, C. Frank; Freier, Susan M.; Kordasiewicz, Holly; Stanek, Lisa; Cleveland, Don W.; Cheng, Seng H.; Shihabuddin, Lamya, Modulation of huntingtin expression.
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    38. Wahlestedt, Claes, Natural antisense and non-coding RNA transcripts as drug targets.
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    39. Verdine, Gregory L.; ., Meena; Iwamoto, Naoki, Nucleic acid prodrugs and methods of use thereof.
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    40. Esau, Christine; Swayze, Eric E.; Bhat, Balkrishen; Kinberger, Garth A., Oligomeric compounds and compositions for the use in modulation of microRNAs.
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    41. Esau, Christine; Swayze, Eric E.; Bhat, Balkrishen; Kinberger, Garth A., Oligomeric compounds and compositions for the use in modulation of micrornas.
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    42. Esau, Christine; Swayze, Eric E.; Bhat, Balkrishen; Kinberger, Garth A., Oligomeric compounds and compositions for the use in modulation of target nucleic acids.
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    43. Bhat, Balkrishen; Dande, Prasad; Prakash, Thazha P.; Allerson, Charles; Swayze, Eric E.; Griffey, Richard H., Oligomeric compounds comprising 4′-thionucleosides for use in gene modulation.
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    44. Oestergaard, Michael; Swayze, Eric E.; Seth, Punit P., Oligomeric compounds comprising alpha-beta-constrained nucleic acid.
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    45. Moore,Max N.; Andrade,Mark; Carty,Recaldo; Scozzari,Anthony; Krotz,Achim, Oligonucleotide synthesis with alternative solvents.
      상세보기
    46. Crooke, Stanley T., Oligoribonucleotides and ribonucleases for cleaving RNA.
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    47. Bhat, Balkrishen; Swayze, Eric E.; Prakash, Thazha P.; Allerson, Charles; Dande, Prasad; Griffey, Richard H., Positionally modified siRNA constructs.
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    48. Song,Quanlai; Ross,Bruce S., Protection of nucleosides.
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    49. Seth, Punit P.; Oestergaard, Michael; Swayze, Eric E., Selective antisense compounds and uses thereof.
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    50. Corey, David R.; Hu, Jiaxin; Matsui, Masayuki, Selective inhibition of polyglutamine protein expression.
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    51. Corey, David R.; Hu, Jiaxin; Matsui, Masayuki, Selective inhibition of polyglutamine protein expression.
      상세보기
    52. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of 'IQ motif containing GTPase activating protein' (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP.
      상세보기
    53. Collard, Joseph; Khorkova Sherman, Olga, Treatment of ABCA1 gene related diseases by inhibition of a natural antisense transcript to ABCA1.
      상세보기
    54. Collard, Joseph; Khorkova Sherman, Olga, Treatment of Adiponectin (ADIPOQ) related diseases by inhibition of natural antisense transcript to an Adiponectin (ADIPOQ).
      상세보기
    55. Collard, Joseph; Khorkova Sherman, Olga, Treatment of Adiponectin related diseases by inhibition of natural antisense transcript to an Adiponectin.
      상세보기
    56. Collard, Joseph; Khorkova Sherman, Olga, Treatment of Frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN.
      상세보기
    57. Collard, Joseph; Khorkova Sherman, Olga, Treatment of LCAT gene related diseases by inhibition of a natural antisense transcript to LCAT.
      상세보기
    58. Collard, Joseph; Khorkova Sherman, Olga, Treatment of Methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA.
      상세보기
    59. Collard, Joseph; Khorkova Sherman, Olga, Treatment of NANOG related diseases by inhibition of natural antisense transcript to NANOG.
      상세보기
    60. Collard, Joseph; Khorkova Sherman, Olga, Treatment of NANOG related diseases by inhibition of natural antisense transcript to NANOG.
      상세보기
    61. Collard, Joseph; Khorkova Sherman, Olga, Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4.
      상세보기
    62. Collard, Joseph; Khorkova Sherman, Olga, Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4.
      상세보기
    63. Collard, Joseph; Khorkova Sherman, Olga, Treatment of PAR4 related diseases by inhibition of natural antisense transcript to PAR4.
      상세보기
    64. Collard, Joseph; Khorkova Sherman, Olga, Treatment of Paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1.
      상세보기
    65. Collard, Joseph; Khorkova Sherman, Olga, Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1.
      상세보기
    66. Collard, Joseph; Khorkova Sherman, Olga, Treatment of RNASE H1 related diseases by inhibition of natural antisense transcript to RNASE H1.
      상세보기
    67. Collard, Joseph; Khorkova Sherman, Olga, Treatment of adiponectin (ADIPOQ) related diseases by inhibition of natural antisense transcript to an adiponectin (ADIPOQ).
      상세보기
    68. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos; Shen, Gang, Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA.
      상세보기
    69. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos; Shen, Gang, Treatment of alpha-L-iduronidase (IDUA) related diseases by inhibition of natural antisense transcript to IDUA.
      상세보기
    70. Collard, Joseph; Khorkova Sherman, Olga, Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene.
      상세보기
    71. Collard, Joseph; Khorkova Sherman, Olga, Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene.
      상세보기
    72. Collard, Joseph; Khorkova Sherman, Olga, Treatment of antiviral gene related diseases by inhibition of natural antisense transcript to an antiviral gene.
      상세보기
    73. Collard, Joseph; Khorkova, Olga, Treatment of apolipoprotein-A1 related diseases by inhibition of natural antisense transcript to apolipoprotein-A1.
      상세보기
    74. Collard, Joseph; Khorkova Sherman, Olga, Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1.
      상세보기
    75. Collard, Joseph; Khorkova Sherman, Olga, Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1.
      상세보기
    76. Collard, Joseph; Khorkova Sherman, Olga, Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1.
      상세보기
    77. Collard, Joseph; Khorkova Sherman, Olga, Treatment of atonal homolog 1 (ATOH1) related diseases by inhibition of natural antisense transcript to ATOH1.
      상세보기
    78. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of brain derived neurotrophic factor (BDNF) related diseases by inhibition of natural antisense transcript to BDNF.
      상세보기
    79. Collard, Joseph; Khorkova Sherman, Olga, Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisene transcript to CSF3.
      상세보기
    80. Collard, Joseph; Khorkova Sherman, Olga, Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3.
      상세보기
    81. Collard, Joseph; Khorkova Sherman, Olga, Treatment of colony-stimulating factor 3 (CSF3) related diseases by inhibition of natural antisense transcript to CSF3.
      상세보기
    82. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1.
      상세보기
    83. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of delta-like 1 homolog (DLK1) related diseases by inhibition of natural antisense transcript to DLK1.
      상세보기
    84. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG.
      상세보기
    85. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG.
      상세보기
    86. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of discs large homolog (DLG) related diseases by inhibition of natural antisense transcript to DLG.
      상세보기
    87. Collard, Joseph; Khorkova Sherman, Olga, Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene.
      상세보기
    88. Collard, Joseph; Khorkova Sherman, Olga, Treatment of down syndrome gene related diseases by inhibition of natural antisense transcript to a down syndrome gene.
      상세보기
    89. Collard, Joseph; Khorkova Sherman, Olga, Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to DMD family.
      상세보기
    90. Collard, Joseph; Khorkova Sherman, Olga, Treatment of dystrophin family related diseases by inhibition of natural antisense transcript to DMD family.
      상세보기
    91. Collard, Joseph; Khorkova Sherman, Olga, Treatment of erythropoietin (EPO) related diseases by inhibition of natural antisense transcript to EPO.
      상세보기
    92. Collard, Joseph; Sherman, Olga Khorkova, Treatment of erythropoietin (EPO) related diseases by inhibition of natural antisense transcript to EPO.
      상세보기
    93. Collard, Joseph; Khorkova Sherman, Olga, Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21.
      상세보기
    94. Collard, Joseph; Khorkova Sherman, Olga, Treatment of fibroblast growth factor 21 (FGF21) related diseases by inhibition of natural antisense transcript to FGF21.
      상세보기
    95. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of filaggrin (FLG) related diseases by modulation of FLG expression and activity.
      상세보기
    96. Collard, Joseph; Khorkova Sherman, Olga, Treatment of frataxin (FXN) related diseases by inhibition of natural antisense transcript to FXN.
      상세보기
    97. Collard, Joseph; Khorkova Sherman, Olga, Treatment of hepatocyte growth factor (HGF) related diseases by inhibition of natural antisense transcript to HGF.
      상세보기
    98. Collard, Joseph; Khorkova Sherman, Olga, Treatment of hepatocyte growth factor (HGF) related diseases by inhibition of natural antisense transcript to HGF.
      상세보기
    99. Collard, Joseph; Khorkova Sherman, Olga, Treatment of insulin gene (INS) related diseases by inhibition of natural antisense transcript to an insulin gene (INS).
      상세보기
    100. Collard, Joseph; Khorkova Sherman, Olga, Treatment of insulin receptor substrate 2 (IRS2) related diseases by inhibition of natural antisense transcript to IRS2 and transcription factor E3 (TFE3).
      상세보기
    101. Collard, Joseph; Khorkova Sherman, Olga, Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8.
      상세보기
    102. Collard, Joseph; Sherman, Olga Khorkova, Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8.
      상세보기
    103. Collard, Joseph; Khorkova Sherman, Olga, Treatment of membrane bound transcription factor peptidase, site 1 (MBTPS1) related diseases by inhibition of natural antisense transcript to MBTPS1.
      상세보기
    104. Collard, Joseph; Khorkova Sherman, Olga, Treatment of membrane bound transcription factor peptidase, site 1 (MBTPS1) related diseases by inhibition of natural antisense transcript to MBTPS1.
      상세보기
    105. Collard, Joseph; Khorkova Sherman, Olga, Treatment of methionine sulfoxide reductase a (MSRA) related diseases by inhibition of natural antisense transcript to MSRA.
      상세보기
    106. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of nuclear factor (erythroid-derived 2)-like 2 (NRF2) related diseases by inhibition of natural antisense transcript to NRF2.
      상세보기
    107. Collard, Joseph; Khorkova Sherman, Olga, Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1.
      상세보기
    108. Collard, Joseph; Khorkova Sherman, Olga, Treatment of nuclear respiratory factor 1 (NRF1) related diseases by inhibition of natural antisense transcript to NRF1.
      상세보기
    109. Collard, Joseph; Khorkova Sherman, Olga, Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene.
      상세보기
    110. Collard, Joseph; Khorkova Sherman, Olga, Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene.
      상세보기
    111. Collard, Joseph; Khorkova Sherman, Olga, Treatment of paraoxonase 1 (PON1) related diseases by inhibition of natural antisense transcript to PON1.
      상세보기
    112. Collard, Joseph; Khorkova Sherman, Olga, Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related disease by inhibition of natural antisense transcript to PYCR1.
      상세보기
    113. Collard, Joseph; Khorkova Sherman, Olga, Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1.
      상세보기
    114. Collard, Joseph; Khorkova Sherman, Olga, Treatment of pyrroline-5-carboxylate reductase 1 (PYCR1) related diseases by inhibition of natural antisense transcript to PYCR1.
      상세보기
    115. Collard, Joseph; Khorkova Sherman, Olga, Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor.
      상세보기
    116. Collard, Joseph; Khorkova Sherman, Olga, Treatment of reprogramming factor related diseases by inhibition of natural antisense transcript to a reprogramming factor.
      상세보기
    117. Collard, Joseph; Khorkova Sherman, Olga, Treatment of sex hormone binding globulin (SHBG) related diseases by inhibition of natural antisense transcript to SHBG.
      상세보기
    118. Collard, Joseph; Khorkova Sherman, Olga, Treatment of sialidase 4 (NEU4) related diseases by inhibition of natural antisense transcript to NEU4.
      상세보기
    119. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos; De Leon, Belinda, Treatment of sirtuin (SIRT) related diseases by inhibition of natural antisense transcript to a sirtuin (SIRT).
      상세보기
    120. Collard, Joseph; Khorkova Sherman, Olga; De Leon, Belinda; Coito, Carlos; Hsiao, Jane H., Treatment of sodium channel, voltage-gated, alpha subunit (SCNA) related diseases by inhibition of natural antisense transcript to SCNA.
      상세보기
    121. Collard, Joseph; Khorkova Sherman, Olga, Treatment of transcription factor E3 (TFE3) and insulin receptor substrate 2 (IRS2) related diseases by inhibition of natural antisense transcript to TFE3.
      상세보기
    122. Collard, Joseph; Khorkova Sherman, Olga, Treatment of transcription factor E3 (TFE3) and insulin receptor substrate 2(IRS2) related diseases by inhibition of natural antisense transcript to TFE3.
      상세보기
    123. Collard, Joseph; Khorkova Sherman, Olga, Treatment of tristetraproline (TTP) related diseases by inhibition of natural antisense transcript to TTP.
      상세보기
    124. Collard, Joseph; Khorkova Sherman, Olga, Treatment of tristetraproline (TTP) related diseases by inhibition of natural antisense transcript to TTP.
      상세보기
    125. Collard, Joseph; Khorkova Sherman, Olga, Treatment of tumor necrosis factor receptor 2 (TNFR2) related diseases by inhibition of natural antisense transcript to TNFR2.
      상세보기
    126. Collard, Joseph; Khorkova Sherman, Olga, Treatment of tumor necrosis factor receptor 2 (TNFR2) related diseases by inhibition of natural antisense transcript to TNFR2.
      상세보기
    127. Collard, Joseph; Khorkova Sherman, Olga, Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63.
      상세보기
    128. Collard, Joseph; Khorkova Sherman, Olga, Treatment of tumor protein 63 (p63) related diseases by inhibition of natural antisense transcript to p63.
      상세보기
    129. Collard, Joseph; Khorkova Sherman, Olga, Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2.
      상세보기
    130. Collard, Joseph; Khorkova Sherman, Olga, Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2.
      상세보기
    131. Collard, Joseph; Khorkova Sherman, Olga, Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF.
      상세보기
    132. Collard, Joseph; Sherman, Olga Khorkova, Treatment of vascular endothelial growth factor (VEGF) related diseases by inhibition of natural antisense transcript to VEGF.
      상세보기
    133. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of ‘C terminus of HSP70-interacting protein’ (CHIP)related diseases by inhibition of natural antisense transcript to CHIP.
      상세보기
    134. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of ‘C terminus of HSP7O-interacting protein’ (CHIP) related diseases by inhibition of natural antisense transcript to CHIP.
      상세보기
    135. Collard, Joseph; Khorkova Sherman, Olga; Coito, Carlos, Treatment of ‘IQ motif containing gtpase activating protein’ (IQGAP) related diseases by inhibition of natural antisense transcript to IQGAP.
      상세보기

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