초록 ▼

A method and apparatus for non-invasively measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved subject-tailored calibration model. In a calibrat

A method and apparatus for non-invasively measuring a biological attribute, such as the concentration of an analyte, particularly a blood analyte in tissue such as glucose. The method utilizes spectrographic techniques in conjunction with an improved subject-tailored calibration model. In a calibration phase, calibration model data is modified to reduce or eliminate subject-specific attributes, resulting in a calibration data set modeling within--subject physiological variation, sample location, insertion variations, and instrument variation. In a prediction phase, the prediction process is tailored for each target subject separately using a minimal number of spectral measurements from each subject.

대표청구항 ▼

[ What is claimed is:] [1.] A method for generating a prediction result for use on a specific subject to predict a biological attribute of that subject using spectroscopy as a surrogate indirect measurement for a direct measurement of said biological attribute, said method comprising the steps of:(a

[ What is claimed is:] [1.] A method for generating a prediction result for use on a specific subject to predict a biological attribute of that subject using spectroscopy as a surrogate indirect measurement for a direct measurement of said biological attribute, said method comprising the steps of:(a) acquiring a calibration data set and modifying said calibration data set in a manner that reduces the spectral variation due to subject specific attributes;(b) generating a model by applying multivariate analysis to said. modified calibration data set; and(c) using a prediction process to predict an unknown amount of said biological attribute in a target spectroscopic measurement from said specific subject, said prediction process utilizing said model in conjunction with one or more reference measurements.