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[미국특허] Continuous manufacturing method for microspheres and apparatus 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • B01F-003/08
  • B01F-005/06
  • B01F-017/34
출원번호 US-0260412 (1999-03-01)
우선권정보 JP0083946 (1998-03-30)
발명자 / 주소
  • Nakajima Mitsutoshi,JPX
  • Kikuchi Yuji,JPX
  • Sano Yoh,JPX
  • Nabetani Hiroshi,JPX
  • Kawakatsu Takahiro,JPX
  • Kobayashi Isao,JPX
  • Takao Hironoshin,JPX
출원인 / 주소
  • Bio-oriented Technology Research Advancement Institution, JPX
대리인 / 주소
    Carrier, Blackman & Associates, P.C.Carrier
인용정보 피인용 횟수 : 64  인용 특허 : 5

초록 ▼

In an apparatus for continuously manufacturing microspheres, a dispersed phase (O) is supplied to a chamber 27 for the dispersed phase inside of a bulkhead member 26 via a supply port 23. Thereafter, the dispersed phase enters into a gap 31 between a plate 22 via a supply port 29 in a base 25. The d

대표청구항 ▼

[ What is claimed is:] [1.] A method for continuously manufacturing microspheres, comprising the steps of:forcing a pressurized dispersed phase into a continuous phase via a plurality of microchannels having a predetermined width to produce microspheres in the form of emulsions and fine particles su

이 특허에 인용된 특허 (5) 인용/피인용 타임라인 분석

  1. Cook Edward J. (South Hamilton MA) Lagace Arthur P. (Newtonville MA), Apparatus for forming emulsions.
    상세보기
  2. Schwesinger Norbert,DEX ; Frank Thomas,DEX, Device for mixing small quantities of liquids.
    상세보기
  3. Asher William J. (Fanwood NJ) Tsien Hsue C. (Chatham NJ), Liquid membrane generator.
    상세보기
  4. Kopf-Sill Anne R. ; Parce John Wallace, Microfluidic systems incorporating varied channel dimensions.
    상세보기
  5. Nakashima Tadao (Miyazaki JPX) Shimizu Masataka (Miyazaki JPX) Kukizaki Masato (Miyazaki JPX), Monodisperse single and double emulsions and method of producing same.
    상세보기

이 특허를 인용한 특허 (64) 인용/피인용 타임라인 분석

  1. Anderson, Brian L.; Colston, Bill W.; Elkin, Christopher J., Apparatus for chemical amplification based on fluid partitioning in an immiscible liquid.
    상세보기
  2. Hindson, Benjamin J.; Colston, Jr., Billy W.; Ness, Kevin D.; Masquelier, Donald A., Calibrations and controls for droplet-based assays.
    상세보기
  3. Ness, Kevin Dean; Burd, Samuel; Hindson, Benjamin Joseph; Belgrader, Phillip; Colston, Jr., Billy W., Cartridge with lysis chamber and droplet generator.
    상세보기
  4. Anderson, Brian L.; Colston, Bill W.; Elkin, Christopher J., Chemical amplification based on fluid partitioning.
    상세보기
  5. Anderson, Brian L.; Colston, Bill W.; Elkin, Christopher J., Chemical amplification based on fluid partitioning in an immiscible liquid.
    상세보기
  6. Ness, Kevin D.; Arbore, Mark A.; Hurst, Jerry E.; Klein, David L.; Masquelier, Donald A., Detection system for droplet-based assays.
    상세보기
  7. Ness, Kevin D.; Hindson, Benjamin J.; Colston, Jr., Billy W.; Masquelier, Donald A., Device for generating droplets.
    상세보기
  8. Ness, Kevin D.; Kelly, Christopher F.; Masquelier, Donald A., Device for generating droplets.
    상세보기
  9. Link, Darren R.; Zhong, Qun; Watson, Andrew, Digital analyte analysis.
    상세보기
  10. Olson, Jeffrey; Link, Darren R., Digital analyte analysis.
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  11. Saxonov, Serge; Dube, Simant; Regan, John Frederick, Digital assays with multiplexed detection of two or more targets in the same optical channel.
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  12. Ness, Kevin D.; Kelly, Christopher F.; Masquelier, Donald A., Droplet generation for droplet-based assays.
    상세보기
  13. Ness, Kevin D.; Hindson, Benjamin J.; Makarewicz, Jr., Anthony J.; Hiddessen, Amy L., Droplet transport system for detection.
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  14. Colston, Jr., Billy Wayne; Hindson, Benjamin Joseph; Ness, Kevin Dean; Masquelier, Donald Arthur; Milanovich, Fred Paul; Modlin, Douglas N.; Riot, Vincent; Burd, Samuel; Makarewicz, Jr., Anthony Joseph; Belgrader, Phillip, Droplet-based assay system.
    상세보기
  15. Link, Darren Roy; Weitz, David A.; Cristobal-Azkarate, Galder; Cheng, Zhengdong; Ahn, Keunho, Electronic control of fluidic species.
    상세보기
  16. Weitz, David A.; Link, Darren Roy; Cristobal-Azkarate, Galder; Cheng, Zhengdong; Ahn, Keunho, Electronic control of fluidic species.
    상세보기
  17. Hiddessen, Amy L.; Hindson, Benjamin J., Emulsion chemistry for encapsulated droplets.
    상세보기
  18. Kawai, Akira; Kitayama, Koji; Futami, Toru; Hara, Katsuyuki; Ohkawa, Tomohiro; Nishizawa, Keiichiro; Kiriya, Hideaki; Kusakabe, Hirotatsu, Fine channel device, fine particle producing method and solvent extraction method.
    상세보기
  19. Ness, Kevin D.; Masquelier, Donald A.; Colston, Jr., Billy W.; Hindson, Benjamin J., Flow-based thermocycling system with thermoelectric cooler.
    상세보기
  20. Link, Darren Roy; Weitz, David A.; Marquez-Sanchez, Manuel; Cheng, Zhengdong, Formation and control of fluidic species.
    상세보기
  21. Link, Darren Roy; Weitz, David A.; Marquez-Sanchez, Manuel; Cheng, Zhengdong, Formation and control of fluidic species.
    상세보기
  22. Saxonov, Serge; Tzonev, Svilen S.; Lucero, Michael Y.; Koehler, Ryan T.; Hindson, Benjamin J., Library characterization by digital assay.
    상세보기
  23. Fraden, Seth; Cristobal-Azkarate, Galder, Manipulation of fluids and reactions in microfluidic systems.
    상세보기
  24. Fraden, Seth; Boukellal, Hakim; Jia, Yanwei; Selimovic, Seila; Rowat, Amy; Agresti, Jeremy; Weitz, David A., Manipulation of fluids, fluid components and reactions in microfluidic systems.
    상세보기
  25. Stone, Howard A.; Anna, Shelley L.; Bontoux, Nathalie; Link, Darren Roy; Weitz, David A.; Gitlin, Irina; Kumacheva, Eugenia; Garstecki, Piotr; Diluzio, Willow R.; Whitesides, George M., Method and apparatus for fluid dispersion.
    상세보기
  26. Nakajima, Mitsutoshi; Fujita, Hiroyuki; Kikuchi, Yuji; Kobayashi, Isao, Method and apparatus for manufacturing microspheres.
    상세보기
  27. Anderson, Brian L.; Colston, Bill W.; Elkin, Christopher J., Method for chemical amplification based on fluid partitioning in an immiscible liquid.
    상세보기
  28. Anderson, Brian L.; Colston, Bill W.; Elkin, Christopher J., Method for chemical amplification based on fluid partitioning in an immiscible liquid.
    상세보기
  29. Takagi,Seiichi; Ohta,Tetsuo, Method for delivering a fine particle dispersion, and device for delivering a fine particle dispersion.
    상세보기
  30. Takagi,Seiichi; Inami,Kazuki; Ohta,Tetsuo, Method for delivering fine particle dispersion, and device for delivering fine particle dispersion.
    상세보기
  31. Windhab, Erich J.; Schadler, Verena; Troxler, Beat; Dürig, Andreas Kurt; Grohmann, Fred-Rainer, Method for gentle mechanical generation of finely dispersed micro-/nano-emulsions with narrow particle size distribution and device for carrying out said method.
    상세보기
  32. Hindson, Benjamin J.; Ness, Kevin D.; Colston, Jr., Billy W.; Milanovich, Fred P.; Masquelier, Donald A., Method of generating droplets.
    상세보기
  33. Ness, Kevin D.; Hindson, Benjamin J.; Colston, Jr., Billy W.; Masquelier, Donald A., Method of making a device for generating droplets.
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  34. Hindson, Benjamin J.; Colston, Jr., Billy W.; Ness, Kevin D.; Masquelier, Donald A., Method of mixing fluids by coalescence of multiple emulsions.
    상세보기
  35. Saxonov, Serge, Methods and compositions for nucleic acid analysis.
    상세보기
  36. Saxonov, Serge, Methods and compositions for nucleic acid analysis.
    상세보기
  37. Saxonov, Serge, Methods and compositions for nucleic acid analysis.
    상세보기
  38. Link, Darren Roy; Weitz, David A.; Cristobal-Azkarate, Galder; Cheng, Zhengdong; Ahn, Keunho, Methods of introducing a fluid into droplets.
    상세보기
  39. Link, Darren R.; Boitard, Laurent; Branciforte, Jeffrey; Charles, Yves; Feke, Gilbert; Lu, John Q.; Marran, David; Tabatabai, Ahmadali; Weiner, Michael; Hinz, Wolfgang; Rothberg, Jonathan M., Microfluidic devices and methods of use in the formation and control of nanoreactors.
    상세보기
  40. Link, Darren R.; Boitard, Laurent; Branciforte, Jeffrey; Charles, Yves; Feke, Gilbert; Lu, John Q.; Marran, David; Tabatabai, Ahmadali; Weiner, Michael; Hinz, Wolfgang; Rothberg, Jonathan M., Microfluidic devices and methods of use in the formation and control of nanoreactors.
    상세보기
  41. Link, Darren; Boitard, Laurent; Branciforte, Jeffrey; Charles, Yves; Feke, Gilbert; Lu, John Q.; Marran, David; Tabatabai, Ahmadali; Weiner, Michael; Hinz, Wolfgang; Rothberg, Jonathan M., Microfluidic devices and methods of use in the formation and control of nanoreactors.
    상세보기
  42. Saxonov, Serge; Dube, Simant; Hindson, Benjamin J.; McCoy, Adam M., Multiplexed digital assays with combinatorial use of signals.
    상세보기
  43. Buenger, Joachim; Driller, Hansjürgen; Zur Lange, Jutta; Wagner, Annette, Packaging system for cosmetic formulations.
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  44. Higuchi, Toshiro; Torii, Toru; Nishisako, Takashi; Taniguchi, Tomohiro, Process and apparatus for producing emulsion and microcapsules.
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  45. Higuchi, Toshiro; Torii, Toru; Nishisako, Takashi; Taniguchi, Tomohiro, Process and apparatus for producing emulsion and microcapsules.
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  46. Higuchi, Toshiro; Torii, Toru; Nishisako, Takashi; Taniguchi, Tomohiro, Process and apparatus for producing emulsion and microcapsules.
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  47. Higuchi,Toshiro; Torii,Toru; Nishisako,Takashi; Taniguchi,Tomohiro, Process and apparatus for producing emulsion and microcapsules.
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  48. Yamada, Kenji; Tatematsu, Shin; Yamada, Kazuhiko, Process and apparatus for producing inorganic spheres.
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  49. Higuchi,Toshiro; Torii,Toru; Nishisako,Takashi; Taniguchi,Tomohiro, Process for producing emulsion and microcapsules and apparatus therefor.
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  50. Nakajima, Mitsutoshi; Nishi, Taiji; Kanai, Seiichi; Kitani, Takenori; Fukuda, Motohiro, Process for producing microsphere with use of metal substrate having through-hole.
    상세보기
  51. Cauley, III, Thomas H.; Bousse, Luc; Petersen, Jonathan; Ness, Kevin D.; Romine, Steven, Sample holder with a well having a wicking promoter.
    상세보기
  52. Makarewicz, Anthony J.; Hiddessen, Amy L., System for detection of spaced droplets.
    상세보기
  53. Makarewicz, Jr., Anthony J.; Hiddessen, Amy L., System for detection of spaced droplets.
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  54. Hindson, Benjamin Joseph; Ness, Kevin Dean; Colston, Jr., Billy Wayne; Milanovich, Fred Paul; Masquelier, Donald Arthur; Makarewicz, Jr., Anthony Joseph, System for droplet-based assays using an array of emulsions.
    상세보기
  55. Hindson, Benjamin Joseph; Ness, Kevin Dean; Colston, Jr., Billy Wayne; Milanovich, Fred Paul; Masquelier, Donald Arthur; Makarewicz, Jr., Anthony Joseph, System for forming an array of emulsions.
    상세보기
  56. Ness, Kevin D.; Hindson, Benjamin J.; Colston, Jr., Billy W.; Masquelier, Donald A., System for forming an array of emulsions.
    상세보기
  57. Hiddessen, Amy L.; Masquelier, Donald A.; Ness, Kevin D.; Hindson, Benjamin J.; Makarewicz, Jr., Anthony J.; Chia, Erin R., System for forming emulsions.
    상세보기
  58. Hiddessen, Amy L.; Ness, Kevin D.; Hindson, Benjamin J.; Masquelier, Donald A.; Chia, Erin R., System for generating droplets with pressure monitoring.
    상세보기
  59. Hiddessen, Amy L.; Ness, Kevin D.; Hindson, Benjamin J.; Masquelier, Donald A.; Chia, Erin R., System for generating droplets with push-back to remove oil.
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  60. Hiddessen, Amy L.; Ness, Kevin D.; Hindson, Benjamin J.; Masquelier, Donald A., System for generating droplets—instruments and cassette.
    상세보기
  61. Hindson, Benjamin J., System for hot-start amplification via a multiple emulsion.
    상세보기
  62. Hindson, Benjamin J.; Colston, Jr., Billy W.; Ness, Kevin D.; Masquelier, Donald A., System for mixing fluids by coalescence of multiple emulsions.
    상세보기
  63. Hindson, Benjamin Joseph; Ness, Kevin Dean; Colston, Jr., Billy Wayne; Milanovich, Fred Paul; Masquelier, Donald Arthur; Makarewicz, Jr., Anthony Joseph, System for transporting emulsions from an array to a detector.
    상세보기
  64. Link, Darren R., Systems for handling microfludic droplets.
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