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Upregulation of Type III endothelial cell nitric oxide synthase by rho GTPase function inhibitors 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-038/02
  • A61K-038/45
  • A61K-039/395
출원번호 US-0132849 (1998-08-11)
발명자 / 주소
  • Liao James K.
출원인 / 주소
  • Brigham and Women's Hospital, Inc.
대리인 / 주소
    Wolf, Greenfield & Sacks, P.C.
인용정보 피인용 횟수 : 20  인용 특허 : 41

초록 ▼

A use for rho GTPase function inhibitors is provided. In the instant invention, rho GTPase function inhibitors are found to upregulate endothelial cell Nitric Oxide Synthase activity. As a result, rho GTPase function inhibitors are useful in treating or preventing conditions that result from the abn

대표청구항 ▼

[ We claim:] [1.] A method for treating a subject to increase endothelial cell Nitric Oxide Synthase activity in a tissue, comprising:administering to a subject in need of such treatment a rho GTPase function inhibitor in an amount effective to increase endothelial cell Nitric Oxide Synthase activit

이 특허에 인용된 특허 (41)

  1. Glamkowski Edward J. (Warren NJ) Fortunato James M. (North Wales PA), 1-(Aminoalkylphenyl and aminoalkylbenzyl)-indoles and indolines and analgesic method of use thereof.
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  6. Anderson Paul L. (Randolph NJ), Erythro-(E)-7-[3′-C1-3alkyl-1′-(3″,5″-dimethylphenyl)naphth-2′-yl]-3,5-dihydroxyhept-6-enoic acids an.
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  7. Bradfute David L. (Wooster OH) Simoni Robert D. (Palo Alto CA), Farnesyl compounds as cholesterol lowering agents.
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  8. Smith Robert L. (Lansdale PA) Halczenko Wasyl (Hatfield PA) Hartman George D. (Lansdale PA) Stokker Gerald E. (Gwynedd Valley PA) Inamine Edward S. (Rahway NJ) Hensens Otto D. (Red Bank NJ) Houck Dav, HMG-CoA reductase inhibitors.
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  9. Monaghan Richard L. (Somerset NJ) Alberts Alfred W. (Short Hills NJ) Hoffman Carl H. (Scotch Plains NJ) Albers-Schonberg George (Princeton NJ), Hypocholesteremic fermentation products and process of preparation.
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  15. Terahara Akira (Hiromachi JPX) Tanaka Minoru (Hiromachi JPX), ML-236B Derivatives and their preparation.
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  17. Kaesemeyer Wayne H., Method and formulation for treating vascular disease.
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  18. Kaesemeyer W. H., Method and formulation of stimulating nitric oxide synthesis.
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  19. Kaesemeyer W. H. (2433 McDowell St. August GA 30904), Method and formulation of stimulating nitric oxide synthesis.
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  20. Olukotun Adeove Y. (Hopewell NJ) Alexander John C. (Winnetka IL), Method for preventing a second heart attack employing an HMG CoA reductase inhibitor.
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  21. Tschollar Werner (Lawrenceville NJ) Yonce Cary S. (Newtown PA) Bergey James L. (Lansdale PA) Kawano James C. (Narberth PA), Method for preventing onset of hypertension employing a cholesterol lowering drug.
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  22. Tschollar Werner (Lawrenceville NJ) Yonce Cary S. (Newtown PA) Bergey James L. (Lansdale PA) Kawano James C. (Narberth PA), Method for preventing onset of hypertension employing a cholesterol lowering drug.
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  23. Hirsch Gerald P. (Atlanta GA) Bayless Robert K. (Austin TX), Methods for inhibiting inflammatory ischemic, thrombotic and cholesterolemic disease response with methionine compounds.
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  24. Baran John S. (Winnetka IL) Liang Chi-Dean (Glenview IL), Octahydronapthalenes.
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  25. Joshi Yatindra M. (Piscataway NJ) Chiesa Pierina (South Orange NJ) Jain Nemichand B. (Monmouth Junction NJ), Pharmaceutical compositions having good stability.
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  26. Nakajima Masahide (Hirakata JPX) Nakamura Norifumi (Hirakata JPX) Wang Feng (Hirakata JPX) Yamanouchi Koichi (Hirakata JPX) Hayashi Kazutaka (Hirakata JPX) Kido Hideaki (Hirakata JPX) Kubo Yoshiji (H, Pharmaceutical use of dihydropyridine derivative.
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  27. Murugesan Natesan (Lawrenceville NJ) Hunt John T. (Princeton NJ) Stein Philip D. (Princeton NJ), Phenyl sulfonamide endothelin antagonists.
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  28. Endo Akira (Tokyo JA) Kuroda Masao (Tokyo JA) Terahara Akira (Tokyo JA) Tsujita Yoshio (Tokyo JA) Tamura Chihiro (Tokyo JA), Physiologically active substances.
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  30. Chen Shieh-Shung J. (Morganville NJ) Arison Byron H. (Watchung NJ), Process for the preparation of 3-keto, 5-hydroxy simvastatin analogs.
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  31. Heath ; Jr. William F. (Fishers IN) McDonald ; III John H. (Carmel IN) Paal Michael (Hamburg DEX) Ruhter Gerd (Hamburg DEX) Schotten Theo (Vierhofen DEX) Stenzel Wolfgang (Reinbek DEX), Protein kinase C inhibitors.
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  32. Kleinschroth Jrgen (Denzlingen DEX) Hartenstein Johannes (Stegen-Wittental DEX) Schchtele Christoph (Freiburg DEX) Rudolph Claus (Vrstetten DEX) Dooley David J. (Freiburg DEX) Weinheimer Gnther (Denz, Pyrrolocarbazole derivatives, compositions containing them, and methods for using them.
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  36. Lane Ronald H. (Phoenix AZ) Qureshi Asaf A. (Madison WI) Salser Winston A. (Pacific Palisades CA), Tocotrienols and tocotrienol-like compounds and methods for their use.
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  37. Maiese Kenneth (New York NY) Wagner John A. (New York NY), Treatment of stroke or in anticipation of the occurrence of brain ischemia.
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  38. Cooke John P. (Palo Alto CA) Dzau Victor J. (Los Altos Hills CA) Gibbons Gary H. (Palo Alto CA), Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production of activity.
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  39. Cooke John P. ; Dzau Victor J. ; Gibbons Gary H., Treatment of vascular degenerative diseases by modulation of endogenous nitric oxide production or activity.
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  40. Vedder Nicholas B. ; Nudelman Edward D., Use of angiogenic lipids for vascularizing tissue.
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  41. Roth Bruce D. (Ann Arbor MI), [R-(R*R*)]-2-(4-fluorophenyl)-bd 상세보기

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  20. Liao, James K., Upregulation of type III endothelial cell nitric oxide synthase by agents that disrupt actin cytoskeletal organization.
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