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Ultrasonic and growth factor bone-therapy: apparatus and method 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61B-017/56
출원번호 US-0232101 (1999-01-15)
발명자 / 주소
  • Kaufman Jonathan J.
  • Chiabrera Alessandro,ITX
대리인 / 주소
    Rader, Fishman & Grauer PLLC
인용정보 피인용 횟수 : 58  인용 특허 : 51

초록 ▼

Non-invasive therapeutic treatment of bone in vivo using ultrasound in conjunction with application of a biochemical compound or bone growth factor is performed by subjecting bone to an ultrasound signal supplied to an ultrasound transducer placed on the skin of a bony member, and involving a repeti

대표청구항 ▼

[ What is claimed is:] [13.]13. A method of therapeutically treating bone tissue in a living body, the method comprising the steps of:(a) applying exogenously a prescribed amount of a bone growth factor to said living body;(b) applying a mechanical stimulus at sub-ultrasonic frequencies to said bone

이 특허에 인용된 특허 (51)

  1. Winder Alan A. (Westport CT) Talish Roger J. (West Caldwell NJ) Ryaby John P. (West Caldwell NJ), Acoustic system for bone-fracture therapy.
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  2. Talish Roger J. (Fairfield NJ) Ryaby John P. (Essex Fells NJ) Scowen Kenneth J. (Springfield NJ) Urgovitch Kenneth J. (Clifton NJ), Apparatus for ultrasonic bone treatment.
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  3. Young Michael J. R. (South Devon GBX) Bradnock Brian R. D. P. (Herts GBX), Apparatus for ultrasonic therapeutic treatment.
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  4. Talish Roger J., Apparatus for ultrasonic treatment of sites corresponding to the torso.
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  5. Falk Rudolf Edgar,CAX ; Asculai Samuel Simon,CAX, Compositions comprising hyaluronic acid and prostaglandin-synthesis-inhibiting drugs.
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  6. Erickson John H. (Plano TX) Tepper John C. (Carrollton TX), Contoured triangular transducer system for PEMF therapy.
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  7. McLeod Bruce R. (Bozeman MT) Smith Stephen D. (Lexington KY) Liboff Abraham R. (Birmingham MI), Deformable magnetic field aiding coils for use in controlling tissue growth.
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  8. Elia James P., Dental implant.
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  9. Fox Martin D. (Storrs CT), Disposable piezoelectric polymer bandage for percutaneous delivery of drugs and method for such percutaneous delivery (a.
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  10. Shimada Jin (Falcon Heights MN) Shapland James E. (Shoreview ; both MN), Drug delivery by multiple frequency phonophoresis.
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  11. Balazs Endre A. (Ft. Lee NJ) Leshchiner Adolf (Fairview NJ) Larsen Nancy E. (Ridgefield Park NJ), Drug delivery systems based on hyaluronans derivatives thereof and their salts and methods of producing same.
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  12. Faccioli, Giovanni; Venturini, Daniele, Dynamic axial splint.
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  13. Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT), Enhancement of transdermal delivery with ultrasound and chemical enhancers.
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  14. Ryaby John P. (Essex Fells NJ) Talish Roger J. (Fairfield NJ) McCabe Joan M. (White Plains NY), Gel containment structure.
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  15. Breitbart Arnold S. ; Grande Daniel S. ; Mason James M., Genetic engineering of cells to enhance healing and tissue regeneration.
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  16. Edwards David A., Hydrogels or lipogels with enhanced mass transfer for transdermal drug delivery.
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  17. Becker Robert O. ; Flick A. Bartholomew ; Becker Adam J., Iontopheretic system for stimulation of tissue healing and regeneration.
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  18. Driller Jack (Ridgewood NJ) Faulkenberry William J. (Long Island City NY) Lizzi Frederic L. (Tenafly NJ), Local application of medication with ultrasound.
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  19. Lifshey Arthur L. ; Talish Roger J., Locator method and apparatus.
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  20. Jacobson Jerry I., Magnetic field generating device and method of generating and applying a magnetic field for treatment of specified conditions.
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  21. Talish Roger J. (Fairfield NJ) Lifshey Arthur L. (East Brunswick NJ), Medical device for ultrasonic treatment of living tissue and/or cells.
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  22. McLeod Kenneth J. (Setauket NY) Rubin Clinton T. (Port Jefferson NY), Method and apparatus for inducing a current and voltage in living tissue.
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  23. Katakura Kageyoshi (Tokyo JPX), Method and apparatus for the measurement and medical treatment using an ultrasonic wave.
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  24. Bassett C. Andrew L. (Bronxville NY) Cook Ian A. (Bronxville NY), Method and device for providing active exercise treatment for a patient suffering from a bone disorder.
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  25. Duarte Luiz R. (Rua Campos Sales 2099 Sao Paulo BRX 13560), Method for healing bone fractures with ultrasound.
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  26. McLeod Kenneth J. (28 Setalcott Pl. Setauket NY 11733) Rubin Clinton T. (108 Bleeker St. Port Jefferson NY 11776), Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical l.
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  27. McLeod Kenneth J. (Setauket NY) Rubin Clinton T. (Port Jefferson NY), Method for the promotion of growth, ingrowth and healing of bone tissue and the prevention of osteopenia by mechanical l.
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  28. Ammann Arthur J. (San Rafael CA) Rudman Christopher G. (San Francisco CA), Method of inducing bone growth using TGF-b 상세보기
  • Dellagatta Enrico Michael, Method of ultrasonic therapy.
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  • Oppermann Hermann ; Kuberasampath Thangavel ; Rueger David C. ; Ozkaynak Engin, Methods for inducing endochondral bone formation comprising administering CBMP-2A, CBMP-2B, and/or virants thereof.
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  • Ryaby ; John P. ; Pilla ; Arthur A., Modification of the growth repair and maintenance behavior of living tissue and cells by a specific and selective chang.
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  • Ryaby John P. (Essex Fells NJ) Pilla Arthur A. (Wyckoff NJ), Modification of the growth, repair and maintenance behavior of living tissues and cells by a specific and selective chan.
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  • Kuberasampath Thangavel ; Rueger David C., Osteogenic devices.
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  • Oppermann Hermann (Medway MA) Ozkaynak Engin (Milford MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (Hopkinton MA) Pang Roy H. L. (Medway MA), Osteogenic devices.
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  • Wang Elizabeth A. (Carlisle MA) Wozney John M. (Hudson MA) Rosen Vicki (Boston MA), Osteoinductive factors.
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  • Ogden John E. (Bend OR), Sonophoretic drug delivery system.
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  • Cukier A. David (2604 S. Bala Dr. Tempe AZ 85282), Sound transmission apparatus for uniformly administering chemical composition through the skin.
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  • Liburdy Robert P. (1820 Mountain View Dr. Tiburon CA 94920), Technique for drug and chemical delivery.
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  • Fahim Mostafa S. (Columbia MO), Topical application of medication by ultrasound with coupling agent.
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  • Mitragotri Samir S. ; Blankschtein Daniel ; Langer Robert S., Transdermal delivery of encapsulated drugs.
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  • Kaufman Jonathan J. (112 Willow St. - #1-A Brooklyn NY 11201) Chiabrera Alessandro E. (Viale Cambiaso 1/15 16145 Genoa ITX), Ultrasonic bone-therapy and assessment apparatus and method.
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  • Kaufman Jonathan J. (Brooklyn NY) Chiabrera Alessandro E. (Genoa ITX), Ultrasonic bone-therapy apparatus and method.
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  • Bock Robert T. (Brewster NY), Ultrasonic method and apparatus for cosmetic and dermatological applications.
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  • Talish Roger J. (Fairfield NJ) Lifshey Arthur L. (East Brunswick NJ), Ultrasonic orthopedic treatment head and body-mounting means therefor.
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  • Kaufman Jonathan J. (Brooklyn NY) Chiabrera Alessandro E. (Genoa ITX), Ultrasonic therapy and assessment apparatus and method.
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  • Talish Roger J. (Fairfield NJ) Lifshey Arthur L. (East Brunswick NJ), Ultrasonic transducer device for treatment of living tissue and/or cells.
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  • Talish Roger J. ; Ryaby John P. ; Tanzer Michael,CAX ITX H3X 3H9 ; Bobyn J. Dennis,CAX ITX H4X 2B7, Ultrasonic treatment for bony ingrowth.
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  • Langer Robert S. (Somerville MA) Kost Joseph (Brookline MA), Ultrasonically modulated polymeric devices for delivering compositions.
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  • Kost Joseph (Omer ILX) Levy Drora (Herzlia MA ILX) Langer Robert S. (Somerville MA), Ultrasound enhancement of transdermal drug delivery.
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  • Bommannan Durairaj (San Francisco CA) Okuyama Hirohisa (San Francisco CA) Guy Richard H. (San Francisco CA) Stauffer Paul (San Rafael CA) Flynn Gordon L. (Ann Arbor MI), Ultrasound-enhanced delivery of materials into and through the skin.
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  • Dunstan Colin R. (San Antonio TX) Izbicka Elzbieta (San Antonio TX) Mundy Gregory R. (San Antonio TX) Burgess Wilson (Gaithersburg MD) Jaye Michael C. (Glenside PA), Use of fibroblast growth factors to stimulate bone growth.
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