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[미국특허] High-throughput screening method and apparatus 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12M-001/34
출원번호 US-0202658 (1999-05-14)
국제출원번호 PCT/US97/11211 (1997-06-26)
§371/§102 date 19990514 (19990514)
국제공개번호 WO-9749987 (1997-12-31)
발명자 / 주소
  • Malin Patricia J.
  • Wada Kenneth R.
  • Dehlinger Peter J.
출원인 / 주소
  • Cellstat Technologies, Inc.
대리인 / 주소
    Brezner
인용정보 피인용 횟수 : 47  인용 특허 : 5

초록 ▼

High-throughout screening method and apparatus are described. The method includes placing cells on a substrate defining a plurality of discrete microwells, at a well density of greater than about 100/cm.sup.2, with the number of sells in each well being less that about 1000, and where the cells in e

대표청구항 ▼

[ What is claimed is:] [1.]1. High throughput screening apparatus comprisinga substrate defining a plurality of discrete microwells on a substrate surface, at a well density of greater than about 100/cm.sup.2, where the well volumes are such as to accommodate at most about 10.sup.3 cells/well,means

이 특허에 인용된 특허 (5) 인용/피인용 타임라인 분석

  1. Annen Phillip A. (Mountain View CA) Omura Takeshi (Los Altos CA), Apparatus and method for detecting metabolic activity.
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  2. Hobbs Geoffrey (Aberdeen GB6) Jason Alfred C. (Aberdeen GB6) Richards John C. S. (Old Aberdeen GB6), Detection of bacterial activity.
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  3. Moro Ricardo (14601 134th Ave. Edmonton ; Alberta CAX T5L 4S9), Measurement apparatus for measuring a biological substance within a fluid substrate.
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  4. Girault Hubert Hugues Jacques,GBX ; Seddon Brian Jeffrey,GBX, Microelectrodes and amperometric assays.
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  5. Sugihara Hirokazu,JPX ; Taketani Makoto,JPX ; Mitsumata Tadayasu,JPX, Planar electrode.
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이 특허를 인용한 특허 (47) 인용/피인용 타임라인 분석

  1. Levy,Ronald; Wechser,Mark A.; Lossos,Izidore S.; Tibshirani,Robert J.; Alizadeh,Ash A.; Botstein,David, Classification of patients having diffuse large B-cell lymphoma based upon gene expression.
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  2. Levy, Ronald; Wechser, Mark A.; Lossos, Izidore S.; Tibshirani, Robert J.; Alizadeh, Ash A.; Botstein, David, Classification of patients having diffuse large b-cell lymphoma based upon gene expression.
    상세보기
  3. Li, Nan; Wang, Xiaobo; Abassi, Yama A.; Xi, Biao; Zhang, Wen Fu; Xu, Xiao, Data analysis of impedance-based cardiomyocyte-beating signals as detected on real-time cell analysis (RTCA) cardio instruments.
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  4. Wang, Xiaobo; Abassi, Yama A.; Atienza, Josephine; Xu, Xiao; Xu, Junquan, Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses.
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  5. Wang, Xiaobo; Abassi, Yama A.; Atienza, Josephine; Xu, Xiao; Xu, Junquan, Device and method for electroporation-based delivery of molecules into cells and dynamic monitoring of cell responses.
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  6. Abassi, Yama A.; Yu, Naichen; Atienza, Josephine; Xu, Xiao; Wang, Xiaobo, Dynamic monitoring of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) activity and pathways in living cells using real-time microelectronic cell sensing technology.
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  7. Abassi, Yama A.; Yu, Naichen; Atienza, Josephine; Xu, Xiao; Wang, Xiabo, Dynamic monitoring of activation of G-protein coupled receptor (GPCR) and receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology.
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  8. Abassi, Yama A.; Yu, Naichen; Atienza, Josephine; Xu, Xiao; Wang, Xiaobo, Dynamic monitoring of activation of receptor tyrosine kinase (RTK) in living cells using real-time microelectronic cell sensing technology.
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  9. Wang, Xiaobo; Abassi, Yama; Atienza, Josephine; Xu, Xiao, Dynamic monitoring of cell adhesion and spreading using the RT-CES system.
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  10. Lehto, Dennis A., High density plate filler.
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  11. Reed, Mark T., High density plate filler.
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  12. Reed,Mark T.; Carrillo,Albert L.; Harding,Ian A., High density plate filler.
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  13. Malin,Patricia J.; Wada,Kenneth R.; Dehlinger,Peter J., High throughout screening method and apparatus.
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  14. Owen, David Geraint; Byrne, Nicholas Gerard, High throughput screen.
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  15. Owen, David Geraint; Byrne, Nicholas Gerard, High throughput screen.
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  16. Owen, David Geraint; Byrne, Nicholas Gerard, High throughput screen.
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  17. Owen, David Geraint; Byrne, Nicholas Gerard, High throughput screen.
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  18. Patricia J. Malin ; Kenneth R. Wada ; Peter J. Dehlinger, High throughput screening method and apparatus.
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  19. Schroeder,Kirk S.; Neagle,Bradley D., High-throughput electrophysiological measurement system.
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  20. Wang,Xiaobo; Xu,Xiao, Impedance based apparatuses and methods for analyzing cells and particles.
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  21. Wang, Xiaobo; Xu, Xiao, Impedance based devices and methods for use in assays.
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  22. Xu,Xiao; Wang,Xiaobo, Impedance based devices and methods for use in assays.
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  23. Wang, Xiaobo; Abassi, Yama A.; Xi, Biao; Zhang, Wen Fu; Xu, Xiao, Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution.
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  24. Wang, Xiaobo; Abassi, Yama A.; Xi, Biao; Zhang, Wen Fu; Xu, Xiao, Label-free monitoring of excitation-contraction coupling and excitable cells using impedance based systems with millisecond time resolution.
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  25. Singh,Sharat; Tahir,Hasan, Lipophilic electrophoretic probes.
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  26. Kovacs,Gregory T. A.; Giovangrandi,Laurent, Low cost fabrication of microelectrode arrays for cell-based biosensors and drug discovery methods.
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  27. Xu,Xiao; Abassi,Yama; Wang,Xiaobo, Method for assaying for natural killer, cytotoxic T-lymphocyte and neutrophil-mediated killing of target cells using real-time microelectronic cell sensing technology.
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  28. Shannon, Mark E.; Oldham, Mark F.; Ruff, David W., Method for cross-instrument comparison of gene expression data.
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  29. Abassi, Yama A.; Yu, Naichen; Atienza, Josephine; Xu, Xiao; Wang, Xiaobo, Method of measuring cell-substrate impedance in living cells to identify compounds affecting receptor tyrosine kinase (RTK) activity and pathways.
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  30. Fredericksen, Ross Thomas; Gilliland, Don Alan, Method of using bonding pad as a gasket for electronic subassemblies.
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  31. Van der Weide, Daniel W.; Blattner, Frederick R., Microfabricated microbial growth assay method and apparatus.
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  32. Tsinberg,Pavel; Roycroft,Pat; Falcovitz Gerassi,Yehudit Hannah; Hahn,Soonkap, Microwell biochip.
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  33. Vogel,Horst; Schmidt,Christian, Multiaperture sample positioning and analysis system.
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  34. Vogel,Horst; Schmidt,Christian, Multiaperture sample positioning and analysis system.
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  35. Singh, Sharat; Chan-Hui, Po-Ying, Multiplex analysis using membrane-bound sensitizers.
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  36. Vogel, Horst; Schmidt, Christian, Positioning and electrophysiological characterization of individual cells and reconstituted membrane systems on microstructured carriers.
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  37. Wang, Xiaobo; Abassi, Yama A.; Xu, Xiao; Gan, Jiangbo, Real time electronic cell sensing system and applications for cell-based assays.
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  38. Abassi, Yama A.; Wang, Xiaobo; Xu, Xiao, Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays.
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  39. Abassi, Yama A.; Wang, Xiaobo; Xu, Xiao, Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays.
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  40. Wang, Xiaobo; Xu, Xiao; Abassi, Yama, Real time electronic cell sensing system and applications for cytotoxicity profiling and compound assays.
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  41. Xu, Xiao; Abassi, Yama; Wang, Xiaobo; Gan, Jiangbo, Real time electronic cell sensing systems and applications for cell-based assays.
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  42. Xu,Xiao; Abassi,Yama; Wang,Xiaobo; Gan,Jiangbo, Real time electronic cell sensing systems and applications for cell-based assays.
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  43. Abassi, Yama A.; Wang, Xiaobo; Xu, Xiao, Real-time electronic cell sensing system and applications for cytotoxicity profiling and compound assays.
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  44. Vogel,Horst; Schmidt,Christian, Sample positioning and analysis system.
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  45. Schroeder,Kirk S., System for rapid chemical activation in high-throughput electrophysiological measurements.
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  46. Wang, Xiaobo; Abassi, Yama A.; Zhang, Wen fu; Xu, Xiao, Use of impedance-based cytological profiling to classify cellular response profiles upon exposure to biologically active agents.
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  47. Abassi, Yama A.; Zhao, Li; Ke, Ning; Wang, Xiaobo; Xu, Xiao, Using impedance-based cell response profiling to identify putative inhibitors for oncogene addicted targets or pathways.
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