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Fluorescent donor-acceptor pair with low spectral overlap 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12Q-001/68
  • C12P-019/34
  • C07H-021/04
출원번호 US-0398629 (1999-09-17)
발명자 / 주소
  • Wittwer Carl T.
출원인 / 주소
  • University of Utah Research Foundation
대리인 / 주소
    Barnes & Thornburg
인용정보 피인용 횟수 : 33  인용 특허 : 51

초록 ▼

The present invention relates to fluorescence resonance energy transfer pairs for detecting the presence of a target analyte wherein the donor fluorophore's emission spectrum and the acceptor fluorophore's absorption spectrum overlap by less than 25%. In a preferred embodiment, the present invention

대표청구항 ▼

[ What is claimed is:] [2.]2. A fluorescence resonance energy transfer pair for producing a fluorescent signal under predetermined conditions, said pair comprising a donor fluorophore having an emission spectrum and an acceptor fluorophore having an absorption spectrum, wherein the donor fluorophore

이 특허에 인용된 특허 (51)

  1. Stavrianopoulos Jannis (New York NY) Rabbani Elazar (New York NY) Abrams Samuel B. (New York NY) Wetmur James G. (Scardsdale NY), Analyte detection by means of energy transfer.
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  2. Zaun Peter (Libertyville IL) Bouma Stanley R. (Grayslake IL) Gordon Julian (Lake Bluff IL) Kotlarik John J. (Vernon Hills IL), Apparatus and method for amplifying and detecting target nucleic acids.
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  3. Johnson Larry J. (San Jose CA) Widunas Joseph T. (Berkeley CA), Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooli.
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  4. Mullis Kary B. (La Jolla CA) Johnson Larry (San Jose CA) Leath Richard A. (Berkley CA) Wennberg Timothy J. (Mariposa CA) Mezei Louis M. (Madison WI) Widunas Joseph T. (Freemont CA), Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooli.
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  5. Oka Hisao (Nagoya MD JPX) Ito Yoichiro (Bethesda MD), Apparatus for countercurrent chromatography separations.
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  6. Hosoi Shigeru (Hamamatsu JPX) Fukami Tadashi (Hamamatsu JPX) Tsuji Akihiko (Hamamatsu JPX), Apparatus for detecting denaturation of nucleic acid.
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  7. Rusnak Miro (LaVerne CA) Shively John E. (Arcadia CA) Calaycay Jimmy R. (Arcadia CA), Apparatus for the sequential performance of chemical processes.
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  8. Hallsby G. Anders (Midland MI), Automatic air temperature cycler and method of use in polymerose chain reaction.
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  9. Suzuki Yoshiyuki (Tokyo JPX) Kato Takahiko (Chigasaki JPX), Automatic cycling reaction apparatus and automatic analyzing apparatus using the same.
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  10. Zare Richard N. (Stanford CA) Tsuda Takao (Palo Alto CA), Capillary electrophoresis injection device and method.
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  12. Tehrani Yoossef (Lincoln NE), Capillary electrophoresis technique.
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  13. Andresen Brian D. (Pleasanton CA) Saxena Vinit (Pinole CA), Chromatography column-electrophoresis system.
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  14. Anderwald Cecil E. (3077 Windmill La. Dallas TX 75234), Container means preventing accidental use by children.
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  15. Dutton Edmund L. (Marietta OH) Selfridge Glenn D. (Marietta OH) Tipton Russell C. (Williamstown WV), Controlled atmosphere enclosure.
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  16. Malick Franklin S. (518 Greenleaf Dr. Monroeville PA 15146), Cooking appliance.
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  17. Haugland Richard P. (Eugene OR) Yue Stephen T. (Eugene OR) Millard Paul J. (Eugene OR) Roth Bruce L. (Corvallis OR), Cyclic-substituted unsymmetrical cyanine dyes.
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  18. Stapleton Marilyn J. (Durham NC) Thorpe Villette S. (Goldsboro NC) Jewett Warren R. (Cary NC), Devices for containing biological specimens for thermal processing.
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  19. Sutton Richard C. (Rochester NY) Ponticello Ignazio S. (Pittsford NY) Cummins Thomas J. (Rochester NY) Zander Dennis R. (Penfield NY) Donish William H. (Rochester NY), Element and method for nucleic acid amplification and detection using adhered probes.
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  20. Lee Linda G. ; Spurgeon Sandra L. ; Rosenblum Barnett, Energy transfer dyes with enchanced fluorescence.
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  21. Lee Linda G. ; Spurgeon Sandra L. ; Rosenblum Barnett, Energy transfer dyes with enhanced fluorescence.
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  23. Waggoner Alan S. ; Mujumdar Swati R. ; Mujumdar Ratnakar B., Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer.
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  24. Varano Antonio (Philadelphia PA) Tobias Reginald (Watertown MA), Gas chromatograph for continuous operation with infrared spectrometer.
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  25. Sisti Giorgio (Melzo ITX) Riva Ermete (Merate ITX) Sala Learco (Monza ITX), Gas chromatographic chamber.
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  26. Howe Robert L. (San Ramon CA), Gas chromatographic oven using symmetrical flow of preheated - premixed ambient air.
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  27. Ray Curtis (Benicia CA), Heating and cooling apparatus for chromatography column.
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  28. Gelfand David H. (Oakland CA) Holland Pamela M. (Oakland CA) Saiki Randall K. (Richmond CA) Watson Robert M. (Berkeley CA), Homogeneous assay system using the nuclease activity of a nucleic acid polymerase.
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  29. Sutherland John W. H. (Rochester NY) Patterson David R. (Rochester NY), Homogeneous method for assay of double-stranded nucleic acids using fluorescent dyes and kit useful therein.
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  30. Heller Michael J. (Encinitas CA), Hybridization of polynucleotides conjugated with chromophores and fluorophores to generate donor-to donor energy transfe.
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  31. Atwood John G. (West Redding CT) Haff Lawrence A. (Wilton CT), In situ PCR amplification system.
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  32. Hall Arlie (4204 Rolling Hills Dr. Lexington KY 40511), Insulating cell element and structures composed thereof.
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  33. Zare Richard N. (Stanford CA) Gassmann Ernst (Basel CHX), Laser-excitation fluorescence detection electrokinetic separation.
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  34. Bouma Stanley R. (Grayslake IL) Khalil Omar S. (Libertyville IL) Pabich Edward K. (Chicago IL), Method for detection of nucleic acid using total internal reflectance.
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  35. Wang Chang-Ning J. (Chelmsford MA) Wu Kai-Wuan (Lowell MA), Method for reducing non-specific priming in DNA amplification.
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  36. Hjerten Stellan (Upsala SEX) Srichaiyo Tasanee (Upsala SEX), Multi-point detection method for electrophoresis and chromatography in capillaries.
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  37. Butcher Eugene C. (Portola Valley CA) Picker Louis J. (Dallas TX), Neutrophil LECAM-1 as indicator of neutrophil activation.
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  38. Afeyan Noubar B. (Brookline MA) Regnier Fred E. (West Lafayette IN), On-line product identification in a chromatography effluent by subtraction.
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  39. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
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  40. Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Gelfand David H. (Oakland CA) Horn Glenn (Emeryville CA) Saiki Randall K. (Richmond CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme.
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  41. Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
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  42. Gelfand David H. (Oakland CA) Stoffel Susanne (El Cerrito CA) Lawyer Frances C. (Oakland CA) Saiki Randall K. (Richmond CA), Purified thermostable enzyme.
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  43. Wittwer Carl T. (Salt Lake City UT) Hillyard David R. (Salt Lake City UT) Ririe Kirk M. (Idaho Falls ID), Rapid thermal cycling device.
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  44. Coakley Joseph (Woodland CA) Godsey James (Folsom CA) Sherman David (Sacramento CA), Sealable vessel for containing and processing analytical samples.
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  45. Pace Salvatore J. (Wilmington DE), Silicon semiconductor wafer for analyzing micronic biological samples.
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  46. Leaseburge Emory J. (Lewisburg WV) Thomas Thomas J. (Lewisburg WV), Supercritical fluid chromatograph with pneumatically controlled pump.
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  47. Chien Ring-Ling (San Jose CA) Burgi Dean S. (Palo Alto CA), System and method for improving sample concentration in capillary electrophoresis.
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  48. Coy Richard A. (Grass Lake MI) Waycaster Roy A. (Tecumseh MI), Temperature control apparatus.
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  49. Columbus Richard L. (Rochester NY) Helfer Jeffrey L. (Webster NY) Porte Johannes J. (Webster NY) Wellman Jeffrey A. (Rochester NY), Temperature cycling cuvette.
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  50. Jorgenson James W. (Chapel Hill NC) Bushey Michelle M. (San Antonio TX), Two-dimensional high-performance liquid chromatography/capillary electrophoresis.
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  51. Jorgenson James W. (Chapel Hill NC) Bushey Michelle M. (San Antonio TX), Two-dimensional high-performance liquid chromatography/capillary electrophoresis.
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  1. Maltezos, George; Johnston, Matthew; Goodwin, David; Scherer, Axel; Walker, Christopher I., Apparatus for thermal cycling.
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  2. Smith, Thomas F.; Wold, Arlo; Uhl, Jim; Espy, Mark J., Articles of manufacture for detection of herpes simplex virus.
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  3. Smith, Thomas F.; Wold, Arlo; Uhl, Jim; Espy, Mark J., Articles of manufacture for detection of herpes simplex virus.
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  4. Ochranek, Brian L.; Arnquist, David C.; Oonuma, Takehiko; Tahara, Hirotoshi; Sato, Naoto; Smith, Bradley P., Automated diagnostic analyzers having rear accessible track systems and related methods.
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  5. Ochranek, Brian L.; Arnquist, David C.; Oonuma, Takehiko; Tahara, Hirotoshi; Sato, Naoto, Automated diagnostic analyzers having vertically arranged carousels and related methods.
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  6. Ochranek, Brian L.; Arnquist, David C.; Oonuma, Takehiko; Tahara, Hirotoshi; Sato, Naoto, Automated diagnostic analyzers having vertically arranged carousels and related methods.
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  7. Linnen, Jeffrey M.; Kolk, Daniel P.; Dockter, Janel M.; Getman, Damon K.; Yoshimura, Tadashi; Ho-Sing-Loy, Martha K.; Pollner, Reinhold B.; Stringfellow, Leslie A., Compositions and methods for detecting hepatitis B virus.
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  8. Linnen, Jeffrey M.; Kolk, Daniel P.; Dockter, Janel M.; Getman, Damon K.; Yoshimura, Tadashi; Ho-Sing-Loy, Martha K.; Pollner, Reinhold B.; Stringfellow, Leslie A., Compositions and methods for detecting hepatitis B virus.
    상세보기
  9. Linnen, Jeffrey M.; Kolk, Daniel P.; Dockter, Janel M.; Getman, Damon K.; Yoshimura, Tadashi; Ho-Sing-Loy, Martha K.; Pollner, Reinhold B.; Stringfellow, Leslie A., Compositions and methods for detecting hepatitis B virus.
    상세보기
  10. Uhl, James R.; Cockerill, III, Franklin R.; Aichinger, Christian; Reiser, Astrid, Detection of group B.
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  11. Uhl, James R; Cockerill, III, Franklin R; Aichinger, Christian; Reiser, Astrid, Detection of group B Streptococcus.
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  12. Uhl,James R.; Cockerill, III,Franklin R.; Aichinger,Christian; Reiser,Astrid, Detection of group B streptococcus.
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  13. Espy,Mark J.; Uhl,Jim; Smith,Thomas F., Detection of varicella-zoster virus.
    상세보기
  14. Ochranek, Brian L.; Arnquist, David C., Diagnostic analyzers with pretreatment carousels and related methods.
    상세보기
  15. Belik, Daniel; Josel, Hans-Peter; Herrmann, Rupert; Koenig, Bernard; Mueller, Francis, Dye pair for fluorescence resonance energy transfer (FRET) measurements.
    상세보기
  16. Chapdelaine, Sébastien; Peytavi, Régis; Beliveau, Thomas-Éric; Gaucher, François; Mainville, Patrick, Fluidic centripetal device.
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  17. Peytavi, Régis; Chapdelaine, Sébastien, Fluidic centripetal device.
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  18. Boles, Deborah; Hasson, Kenton C.; Kanderian, Sami, High-resolution melting analysis.
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  19. Boles, Deborah; Hasson, Kenton C.; Kanderian, Sami, High-resolution melting analysis.
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  20. Arciniegas, German; Ceremony, Jeff; Chu, Daniel Y.; Ragsdale, Charles W., Localized temperature control for spatial arrays of reaction media.
    상세보기
  21. Arciniegas, German; Ceremony, Jeff; Chu, Daniel Y.; Ragsdale, Charles W., Localized temperature control for spatial arrays of reaction media.
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  22. Ceremony, Jeff; Chu, Daniel Y., Localized temperature control for spatial arrays of reaction media.
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  23. Christopher Grant Morgan GB, Luminescence assay using cyclical excitation wavelength sequence.
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  24. Willey,James C., Methods and compositions for assaying analytes.
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  25. Willey, James C.; Crawford, Erin L.; Weaver, David A., Methods and compositions for assessing nucleic acids and alleles.
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  26. Higuchi, Russell; Holcomb, Cherie, Multiplex quantitative nucleic acid amplification and melting assay.
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  27. Fawcett, Adrian; Tracy, David; Simmons, Kevin Daley, Optical system for multiple reactions.
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  28. Chun, Jong Yoon, Quantification of target nucleic acid using melting peak analysis.
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  29. Kessler,Christoph; Haberhausen,Gerd; Bartl,Knut; Orum,Henrik, Specific and sensitive nucleic acid detection method.
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  30. Anderson, Timothy T.; Buckley, Rachel Lara Abigal; Daly, Juliette C.; Hsing, John J.; Joseph, Gregory A.; Oglesby, Gary E.; Rogus, John M.; Seaman, Robert C.; Termion, Mark C., Stride adjustment mechanism.
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  31. Maltezos, George; Johnston, Matthew; Goodwin, David; Scherer, Axel; Walker, Christopher I., Thermal cycling apparatus.
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  32. Maltezos, George; Johnston, Matthew; Goodwin, David; Scherer, Axel; Walker, Christopher I., Thermal cycling method.
    상세보기
  33. Maltezos, George; Johnston, Matthew; Goodwin, David; Scherer, Axel; Walker, Christopher I., Thermal cycling system.
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