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Human embryonic germ cell line and methods of use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-005/02
  • C12N-005/00
  • C12N-005/08
출원번호 US-0052772 (1998-03-31)
발명자 / 주소
  • Gearhart John D.
  • Shamblott Michael Joseph
출원인 / 주소
  • The Johns Hopkins University School of Medicine
대리인 / 주소
    Fish & Richardson P.C.
인용정보 피인용 횟수 : 62  인용 특허 : 20

초록 ▼

Primordial germ cells isolated from human embryonic tissue, such as from the gonadal ridges of human embryo, are disclosed. The primordial germ cells are cultured resulting in cells that resemble embryonic stem cells or embryonic germ cells in morphology and pluripotency. The cells are maintained se

대표청구항 ▼

[ What is claimed is:] [1.]1. A method for producing human pluripotent embryonic germ (hEG) cells, comprising culturing human primordial germ cells (PGCs) in a culture medium comprising:(a) a ligand which binds to a receptor which can associate with glycoprotein 130 (gp 130); and(b) a growth factor;

이 특허에 인용된 특허 (20)

  1. Rosenkrans ; Jr. Charles F. (111 Ridge Dr. Mt. Horeb WI 53572) Keefer Carol L. (2204 Beatrice Ct. Madison WI) Sims Michelle M. (2204 Beatrice Ct. Stoughton WI 53589), Bovine embryo medium.
    상세보기
  2. Caplan Arnold I. ; Haynesworth Stephen E., Connective tissue regeneration using human mesenchymal stem cell preparations.
    상세보기
  3. Anderson David J. (Altadena CA) Stemple Derek L. (Newton MA), Genetically engineered mammalian neural crest stem cells.
    상세보기
  4. Tsukamoto Ann (Palo Alto CA) Baum Charles M. (Menlo Park CA) Aihara Yukoh (Hiratsuka CA JPX) Weissman Irving (Palo Alto CA), Human hematopoietic stem cell.
    상세보기
  5. Tsukamoto Ann ; Baum Charles M. ; Aihara Yukoh,JPX ; Weissman Irving, Human hematopoietic stem cell.
    상세보기
  6. Ronnett Gabriele V. (Baltimore MD) Nye Jeffrey S. (New York NY) Hester Lynda D. (Towson MD) Snyder Solomon H. (Baltimore MD), Human neuronal cell line.
    상세보기
  7. Civin, Curt I., Human stem cells and monoclonal antibodies.
    상세보기
  8. Anderson David J. (Altadena CA) Stemple Derek L. (Newton MA), Immoralized neural crest stem cells and methods of making.
    상세보기
  9. Anderson David J. ; Stemple Derek L., In vitro method for obtaining an isolated population of mammalian neural crest stem cells.
    상세보기
  10. Williams Robert L. (Warrndyte AUX) Gough Nicholas M. (North Balwyn AUX) Hilton Douglas J. (Warrandyte AUX), In vitro propagation of embryonic stem cells.
    상세보기
  11. Anderson David J. (Altadena CA) Stemple Derek L. (Pasadena CA), Mammalian neural crest stem cells.
    상세보기
  12. Emerson Stephen G. (Ann Arbor MI) Clarke Michael F. (Ann Arbor MI) Palsson Bernhard O. (Ann Arbor MI), Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultur.
    상세보기
  13. Emerson Stephen G. (Ann Arbor MI) Clarke Michael F. (Ann Arbor MI) Palsson Bernhard O. (Ann Arbor MI) Schwartz Richard M. (Ann Arbor MI), Methods and compositions for the ex vivo replication of human hematopoietic stem cells.
    상세보기
  14. Hill Beth Louis ; Rozler Elen ; Chen Benjamin P., Methods of obtaining compositions enriched for hematopoietic stem cells, antibodies for use therein, compositions derive.
    상세보기
  15. Hogan Brigid L. M. (Brentwood TN), Pluripotential embryonic cells and methods of making same.
    상세보기
  16. Hogan Brigid L. M. (Brentwood TN), Pluripotential embryonic stem cells and methods of making same.
    상세보기
  17. Hogan Brigid L. M. (Brentwood TN), Pluripotential embryonic stem cells and methods of making same.
    상세보기
  18. Thomson James A., Primate embryonic stem cells.
    상세보기
  19. Gerson Stanton L. (Pepper Pike OH) Caplan Arnold I. (Cleveland Heights OH) Haynesworth Stephen E. (Cleveland Heights OH), Transduced mesenchymal stem cells.
    상세보기
  20. Wheeler Matthew B. (Tolono IL), Transgenic swine compositions and methods.
    상세보기

이 특허를 인용한 특허 (62)

  1. Xu,Chunhui, Cardiomyocyte precursors from human embryonic stem cells.
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  2. Libbus, Imad; Ross, Jeffrey; Girouard, Steven D., Cell therapy and neural stimulation for cardiac repair.
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  3. Ahrens, Eric T.; Srinivas, Mangala, Cellular labeling and quantification for nuclear magnetic resonance techniques.
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  4. Ahrens, Eric T., Cellular labeling for nuclear magnetic resonance techniques.
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  5. Ahrens, Eric T., Cellular labeling for nuclear magnetic resonance techniques.
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  6. Condie,Brian G.; Bieberich,Erhard, Compositions and methods for enrichment of neural stem cells using ceramide analogs.
    상세보기
  7. Janjic, Jelena; Ahrens, Eric T., Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques.
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  8. Xu, Chunhui, Compound screening using cardiomyocytes.
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  9. Xu, Chunhui; Gold, Joseph D., Conditioned media for propagating human pluripotent stem cells.
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  10. Thomson,James A.; Levenstein,Mark, Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium.
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  11. Amit, Michal; Itskovitz-Eldor, Joseph, Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state.
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  12. Leonhardt, Howard J; Lashinski, Robert D., Deployment system for myocardial cellular material.
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  13. Gearhart, John D.; Shamblott, Michael Joseph, Differentiation of human embryonic germ cells.
    상세보기
  14. Gold, Joseph D.; Hassanipour, Mohammad, Differentiation of primate pluripotent stem cells to cardiomyocyte-lineage cells.
    상세보기
  15. Xu, Chunhui, Differentiation protocol for making human cardiomyocytes.
    상세보기
  16. Gold, Joseph D.; Hassanipour, Mohammad; Collins, Lila R.; Xu, Chunhui, Direct differentiation method for making cardiomyocytes from human embryonic stem cells.
    상세보기
  17. Gold,Joseph D.; Hassanipour,Mohammad; Collins,Lila R.; Xu,Chunhui, Direct differentiation method for making cardiomyocytes from human embryonic stem cells.
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  18. Ross, Jeffrey; Kim, John; Salo, Rodney W.; Heil, Jr., Ronald W.; Westlund, Randy, Epicardial patch including isolated extracellular matrix with pacing electrodes.
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  19. Vacanti, Joseph P.; Shin, Young-Moon Michael; Ogilvie, Jennifer; Sevy, Alexander; Maemura, Tomoyuki; Ishii, Osamu; Kaazempur-Mofrad, Mohammad Reza; Borenstein, Jeffrey T.; King, Kevin R.; Wang, Chiao-Chun; Weinberg, Eli, Fabrication of vascularized tissue using microfabricated two-dimensional molds.
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  20. Bodnar,Andrea G.; Chiu,Choy Pik; Gold,Joseph D.; Inokuma,Margaret; Murai,James T.; West,Michael D., Feeder-free culture method for embryonic stem cells or primate primordial stem cells.
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  21. Lin, Shi-Lung; Ying, Shao-Yao; Wu, David Ts, Generation of human embryonic stem-like cells using intronic RNA.
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  22. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Human embryonic stem cells genetically modified to contain a nucleic acid and cultured with fibroblast growth factor.
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  23. Consigny, Paul; Asongwe, Gabriel; Michaels, Mary Beth; Michal, Gene; Mandrusov, Evgenia; Lee, Jeong; Ludwig, Florian N.; Henckel, John Eric; Sciacca, Joseph J.; Bueche, Ken; Thornton, Richard Todd; Urrabazo, Fidel Albert; Wiegand, Daniel, Intracoronary device and method of use thereof.
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  24. Allen-Hoffmann, B. Lynn; Centanni, John M., Kit for species specific DNA detection.
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  25. Westlund, Randy; Ross, Jeffrey, Lead electrode incorporating extracellular matrix.
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  26. Amit, Michal; Itskovitz-Eldor, Joseph, Media for culturing stem cells.
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  27. Amit, Michal; Itskovitz-Eldor, Joseph, Medium comprising transforming growth factor beta 1 and basic fibroblast growth factor.
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  28. Amit, Michal; Itskovitz-Eldor, Joseph, Medium comprising transforming growth factor beta 1 and basic fibroblast growth factor.
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  29. Amit, Michal; Itskovitz-Eldor, Joseph, Medium comprising transforming growth factor β1 and basic fibroblast growth factor.
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  30. Girouard, Steven D.; Ross, Jeffrey, Method and apparatus for device controlled gene expression.
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  31. Pastore, Joseph M.; Ross, Jeffrey; Baynham, Tamara Colette; Salo, Rodney W.; Kramer, Andrew P.; Spinelli, Julio C., Method and apparatus for device controlled gene expression for cardiac protection.
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  32. Pastore, Joseph M.; Ross, Jeffrey; Baynham, Tamara Colette; Salo, Rodney W.; Kramer, Andrew P.; Spinelli, Julio C., Method and apparatus for device controlled gene expression for cardiac protection.
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  33. Ross, Jeffrey; Spinelli, Julio C., Method and apparatus for modulating cellular growth and regeneration using ventricular assist device.
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  34. Girouard, Steven D.; Ross, Jeffrey; Salo, Rodney W., Method and apparatus to modulate cellular regeneration post myocardial infarct.
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  35. Girouard, Steven D.; Ross, Jeffrey, Method for preparing an implantable controlled gene or protein delivery device.
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  36. Vacanti, Joseph P.; Rubin, Robert; Cheung, Wing; Borenstein, Jeffrey T., Method of determining metabolism of a test agent.
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  37. Borenstein, Jeffrey T.; Weinberg, Eli J.; Hsiao, James Ching-Ming; Khalil, Ahmad S.; Tupper, Malinda M.; Garcia-Cardena, Guillermo; Mack, Peter; Tao, Sarah L., Method of fabricating microfluidic structures for biomedical applications.
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  38. Kataoka, Masaki; Fukunaga, Hideki; Inoue, Hiroshi; Nishimura, Yuji; Hirakata, Susumu; Imazeki, Atsumichi, Method of producing liquid droplet ejection head.
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  39. Wagner, Darrell O.; Sih, Haris J.; Qu, Jihong; Ross, Jeffrey; Girouard, Steven D.; Heil, Jr., Ronald W., Method of using a lead to regulate protein expression.
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  40. Bodnar, Andrea G.; Chiu, Choy-Pik; Gold, Joseph D.; Inokuma, Margaret; Murai, James T.; West, Michael D., Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture.
    상세보기
  41. McIntosh, Charles L., Methods for intravascular engraftment in heart.
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  42. Amit, Michal; Itskovitz-Eldor, Joseph, Methods of expanding embryonic stem cells in a suspension culture.
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  43. Amit, Michal; Itskovitz-Eldor, Joseph, Methods of expanding embryonic stem cells in a suspension culture.
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  44. Malcuit, Christopher; Lemieux, Linda; Holmes, William; Huertas, Pedro; Vilner, Lucy, Methods of producing RPE cells and compositions of RPE cells.
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  45. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Micro-carrier culture system for rapid expansion of human embryonic stem cells.
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  46. Borenstein, Jeffrey T.; Weinberg, Eli; Orrick, Brian K.; Pritchard, Eleanor M.; Barnard, Edward J.; Krebs, Nicholas J.; Marentis, Theodore; Vacanti, Joseph P.; Kaazempur-Mofrad, Mohammad Reza, Micromachined bilayer unit for filtration of small molecules.
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  47. Borenstein, Jeffrey T.; Weinberg, Eli; Orrick, Brian K.; Pritchard, Eleanor M.; Barnard, Edward J.; Krebs, Nicholas J.; Marentis, Theodore; Vacanti, Joseph P.; Kaazempur-Mofrad, Mohammad Reza, Micromachined bilayer unit of engineered tissues.
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  48. Klimanskaya, Irina V.; Lanza, Robert P., Modalities for the treatment of degenerative diseases of the retina.
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  49. Borenstein,Jeffrey T.; King,Kevin R.; Terai,Hidetomi; Vacanti,Joseph P., Multilayer device for tissue engineering.
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  50. Gliner, Bradford Evan, Neural stimulation system and method responsive to collateral neural activity.
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  51. Hogan,Brigid L. M., Pluripotential embryonic stem cells and methods of making same.
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  52. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Primate pluripotent stem cell expansion without feeder cells and in the presence of FGF and matrigel or Engelbreth-Holm-Swarm tumor cell preparation.
    상세보기
  53. Xu, Chunhui; Gold, Joseph D., Process for making transplantable cardiomyocytes from human embryonic stem cells.
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  54. Smith, Austin Gerard; Burdon, Thomas Grant, Propagation and/or derivation of embryonic stem cells.
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  55. Mandalam, Ramkumar; Xu, Chunhui; Gold, Joseph D.; Carpenter, Melissa K., Screening methods for human embryonic stem cells.
    상세보기
  56. Thomson,James A, Serum free cultivation of primate embryonic stem cells.
    상세보기
  57. Allen Hoffmann,Lynn; Centanni,John M., Species specific DNA detection.
    상세보기
  58. Shogbon, Christopher Bankole; Zhou, Yue; Brandenberger, Ralph, Synthetic surfaces for culturing stem cell derived cardiomyocytes.
    상세보기
  59. Shogbon, Christopher Bankole; Zhou, Yue; Brandenberger, Ralph, Synthetic surfaces for culturing stem cell derived cardiomyocytes.
    상세보기
  60. Shogbon, Christopher Bankole; Zhou, Yue; Brandenberger, Ralph, Synthetic surfaces for culturing stem cell derived cardiomyocytes.
    상세보기
  61. Carpenter, Melissa K.; Thies, R. Scott, Use of TGF beta superfamily antagonists and neurotrophins to make neurons from embryonic stem cells.
    상세보기
  62. Borenstein, Jeffrey T.; Weinberg, Eli J.; Hsiao, James C.; Khalil, Ahmad S.; Tupper, Malinda M.; Garcia-Cardena, Guillermo; Mack, Peter; Tao, Sarah L., microfluidic structures for biomedical applications.
    상세보기

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