[특허]Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds

[미국특허] Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/543 G01N-033/53 B05B-005/00
출원번호	US-0409298 (1995-03-23)
발명자 / 주소	Buechler Kenneth F. Noar Joseph Barry Tadesse Lema
출원인 / 주소	Biosite Diagnostics, Inc.
대리인 / 주소	Foley & Lardner
인용정보	피인용 횟수 : 35 인용 특허 : 14

초록 ▼

The invention describes the particles comprising an energy donor as a first component and a fluorescent dye as a second component positioned in said particles at an energy exchanging distance from one another, wherein the two components have a Stokes shift of greater than or equal to 50 nm, said particle having bound on its surface, a protein, polypeptide, nucleic acid, nucleotide or protein containing ligand analogue are disclosed and claimed. In addition, novel fluorescent dyes are described which exhibit intramolecular energy transfer for use to label various molecules, proteins, polypeptides, nucleotides and nucleic acids or to incorporate into particles.

대표청구항 ▼

[ What is claimed is:] [1.]1. A loadable particle comprising an energy donor as a first component and energy acceptor as a second component positioned in said particle at an energy exchanging distance from one another, wherein the two components have a Stokes shift of greater than or equal to 50 nm, wherein said first component has an excitation wavelength greater than approximately 500 nm, said second component has an emission wavelength greater than approximately 680 nm, and at least one of said first component and said second component is a phthalocyanine derivative having an axial ligand or a naphthalocyanine derivative having an axial ligand; said particle having bound on its surface, a protein, polypeptide, nucleic acid, nucleotide or protein comprising a ligand analogue.

이 특허에 인용된 특허 (14) 인용/피인용 타임라인 분석

Hirschfeld Tomas (Framingham MA), Dye tagged reagent.
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Lippa Arnold S. (Franklin Lakes NJ), Fluorescence immunoassay involving energy transfer between two fluorophores.
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Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Palo Alto CA), Fluorescence quenching with immunological pairs in immunoassays.
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Ullman Edwin F. (Atherton CA) Schwarzberg Moshe (Sunnyvale CA), Fluorescence quenching with immunological pairs in immunoassays.
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Chan Joseph L. W. (Quincy MA), Fluorescent energy transfer with phycobiliproteins.
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Brinkley John M. (Elmira OR) Haugland Richard P. (Eugene OR) Singer Victoria L. (Eugene OR), Fluorescent microparticles with controllable enhanced stokes shift.
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Dreyer William J. (960 San Pasqual ; #302 Pasadena CA 91106), Fluorescent pigments for tagging biological molecules.
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Hale Ron L. (Woodside CA) Solas Dennis W. (San Francisco CA), Fluorescent poly(arylpyridine) rare earth chelates.
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Kleinschmidt Peter (Munich DEX) Mader Gerhard (Unterhaching DEX) Meixner Hans (Haar DEX), Laser beam-induced color printing.
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Hugl Herbert (Bergisch Gladbach DEX) Kuckert Eberhard (West Haven CT) Mbius Dietmar (Waake DEX) Ohst Holger (Odenthal DEX) Rolf Meinhard (Charlston SC) Rosenkranz Hans J. (Krefeld DEX) Schopper Heinr, Optical biosensor and method of use.
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Yoshinaga Kazuo (Machida JPX) Miyamoto Moritoshi (Kawasaki JPX), Particle measuring device.
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Babb Bruce E. (Rochester NY) Oakes Fred T. (Rochester NY), Phenalenimine Fluorescent dyes and their use in analytical methods.
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Babb Bruce E. (Rochester NY) Oakes Fred T. (Rochester NY), Phenalenimine fluorescent dyes and their use in analytical compositions, elements and methods.
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Stryer, Lubert; Glazer, Alexander N., Phycobiliprotein fluorescent conjugates.
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A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Fluorescence energy transfer and intramolecular energy transfer in particles using novel compounds 원문보기