The invention relates to an immunophilin ligand of Formula I and having antiasthmatic, antiallergic, antirheumatic, immunosuppressant, antipsoriatic and neuroprotectant properties,
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[ What is claimed is:] [1.]1. An immunophilin ligand of Formula I:R.sub.1, R.sub.2 and R.sub.5 are independently of each other hydrogen, C.sub.1-12 alkyl or C.sub.2-6 alkoxy groups in which the alkyl group is straight-chain or branched and can be substituted with a mono- or bicyclic heteroaryl resid
[ What is claimed is:] [1.]1. An immunophilin ligand of Formula I:R.sub.1, R.sub.2 and R.sub.5 are independently of each other hydrogen, C.sub.1-12 alkyl or C.sub.2-6 alkoxy groups in which the alkyl group is straight-chain or branched and can be substituted with a mono- or bicyclic heteroaryl residue having 1-4 heteroatoms, or mono- or polysubstituted with a phenyl ring, orR.sub.1 is an amine group of an amino acid methyl ester from the group of histidine, leucine, valine, serine, threonine, pipecolic acid, 4-piperidinecarboxylic acid, 3-piperidinecarboxylic acid, --NH.sub.2,-lysine, --Z-NH-lysine, -(21-Z)-NH-lysine, 2-pyridylalanine, phenylalanine, tryptophan, glutamic acid, arginine, asparagine, citrulline, homocitrulline, ornithine, thiazolecarboxylic acid, proline, 2-indolinecarboxylic acid, octahydroindolinecarboxylic acid, tetrahydroisoquinolinecarboxylic acid, 5-aminovaleric acid, and 8-aminooctanoic acid; andR.sub.2 is an amino C.sub.1-12 alkyl, or an amino C.sub.2-6 alkoxy group wherein the alkyl group is straight-chain or branched and can be substituted with a mono- or bicyclic heteroaryl residue having 1-4 heteroatoms, or mono- or polysubstituted with a phenyl ring,R.sub.3 is H, F, OR.sub.4, Br, NHR.sub.4,R.sub.4 is hydrogen, a C.sub.3-7 cycloalkyl, C.sub.1-6 alkyl, or carboxy C.sub.1-6 alkyl residue wherein the alkyl group is straight-chain or branched,A is without a ring, or an aromatic, non-aromatic, or aromatic heterocyclic or non- aromatic heterocyclic having 1-2 heteroatoms,B is CH.sub.2D is CHB-D is CH.dbd.CX is O, S, H.sub.2Y is S, C, and when X is .dbd.H.sub.2 then a single bond; andZ is S, O, NR.sub.5, vided that when B is CH.sub.2 then D is CH, and when B is CH, then D is C, and its pharmaceutically acceptable salts.
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