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특허 상세정보

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Restriction enzyme mediated adapter

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) C12Q-001/68   
미국특허분류(USC) 435/006 ; 435/005 ; 435/006 ; 435/007 ; 435/091.1 ; 435/091.2 ; 435/501 ; 536/026 ; 536/027 ; 536/028 ; 536/077 ; 536/078 ; 514/100
출원번호 US-0303774 (1999-04-30)
발명자 / 주소
출원인 / 주소
대리인 / 주소
    Bortner
인용정보 피인용 횟수 : 60  인용 특허 : 6
초록
▼

The present invention relate to methods and compositions for simultaneously analyzing multiple different polynucleotides of a polynucleotide composition comprising multiple diverse polynucleotide sequences. The subject methods and compositions may also be applied to analyze or identify single polynucleotides; however, the subject methods and compositions are particularly useful for analyzing large diverse populations of polynucleotides, e.g., cDNA libraries. Most embodiments of the invention involve hybridizing terminus probes (of known base sequence) to...

대표
청구항
▼

[ What is claimed is:] [1.]1. A method of analyzing a polynucleotide, said method comprisingforming a restriction fragment from the polynucleotide, wherein the restriction fragment has a first and second terminus and at least one of the termini is generated by a restriction endonuclease,joining a first adapter to a terminus of the restriction fragment, whereby an adapter-modified restriction fragment is produced, andhybridizing a terminus probe to a single strand of the adapter-modified restriction fragment at a position including the terminus generated ...

이 특허에 인용된 특허 (6)

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  5. Martinelli Richard A. ; Arruda John C.. Hybridization-ligation assays for the detection of specific nucleic acid sequences. USP1998095800994.
  6. Cantor Charles R. (Boston MA). Methods of preparing probe array by hybridation. USP1997055631134.

이 특허를 인용한 특허 피인용횟수: 60

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  8. Jones,Keith W.; Shapero,Michael; Liu,Weiwei. Complexity management of genomic DNA by locus specific amplification. USP2006097108976.
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  15. Drmanac, Radoje; Reid, Clifford. Efficient shotgun sequencing methods. USP2012108298768.
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  17. Drmanac, Radoje. Genome sequence analysis using tagged amplicons. USP2014078765382.
  18. Drmanac, Radoje; Callow, Matthew J.; Drmanac, Snezana; Hauser, Brian K.; Yeung, George. High density DNA array. USP2018049944984.
  19. Drmanac, Radoje T.; Callow, Matthew; Drmanac, Snezana. High throughput genome sequencing on DNA arrays. USP2014058722326.
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  29. Drmanac, Radoje. Methods for DNA sequencing and analysis using multiple tiers of aliquots. USP2017059637784.
  30. Shapero, Michael H.. Methods for genotyping. USP2016079388459.
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